CAS No.6470-18-4,1-Acetamido-7-hydroxynaphthalene Suppliers

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Basic Information

Molecular Structure:
CAS No.:	6470-18-4
Name:	1-Acetamido-7-hydroxynaphthalene
Article Data:	12

Formula:	C₁₂H₁₁NO₂
Molecular Weight:	201.225
Synonyms:	Acetamide,N-(7-hydroxy-1-naphthyl)- (6CI,8CI);1-Acetamido-7-naphthol;1-Acetylamino-7-naphthol;N-(7-Hydroxy-1-naphthyl)acetamide;N-(7-Hydroxynaphthalene-1-yl)-acetamide;NSC 7566;acetamide, N-(7-hydroxy-1-naphthalenyl)-;
EINECS:	229-293-5
Density:	1.297 g/cm³
Melting Point:	168-169 °C
Boiling Point:	486.2 °C at 760 mmHg
Flash Point:	247.9 °C
Hazard Symbols:	Xi
Risk Codes:	R36/37/38
PSA:	49.33000
LogP:	2.57680

Synthetic route

: 29921-56-0
8-acetamidonaphthalen-2-yl acetate

: 6470-18-4
1-acetylamino-7-naphthol

Conditions

Conditions	Yield
With sodium hydrogencarbonate In methanol for 1h; Reflux;	96%
With sodium hydrogencarbonate In methanol

: 118-46-7
8-amino-2-naphthol

: 108-24-7
acetic anhydride

: 6470-18-4
1-acetylamino-7-naphthol

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 21h;	88%

: 118-46-7
8-amino-2-naphthol

: 75-36-5
acetyl chloride

A: 29921-56-0
8-acetamidonaphthalen-2-yl acetate

B: 6470-18-4
1-acetylamino-7-naphthol

Conditions

Conditions	Yield
With pyridine; benzene

...Expand

: 118-46-7
8-amino-2-naphthol

: 6470-18-4
1-acetylamino-7-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: TEA / CHCl3 2: NaHCO3 (sat) / methanol View Scheme
With acetic anhydride In methanol
In ice-water

: 119-28-8
8-amino-2-naphthalenesulfonic acid

: 6470-18-4
1-acetylamino-7-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide; water / 250 - 260 °C View Scheme

: 118-46-7
8-amino-2-naphthol

: 64-19-7
acetic acid

: 6470-18-4
1-acetylamino-7-naphthol

Conditions

Conditions	Yield
With sodium hydroxide at 20 - 40℃; for 2h;	120 g

: 6470-18-4
1-acetylamino-7-naphthol

: 74-88-4
methyl iodide

: 93189-18-5
N-(7-methoxynaphthalen-1-yl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In acetone for 1h; Reflux;	90%
With potassium carbonate In acetone for 6h; Heating;
With potassium carbonate In acetone

: 18908-66-2
2-ethylhexyl bromide

: 6470-18-4
1-acetylamino-7-naphthol

: C20H27NO2

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 9h; Reflux;	88%
With potassium carbonate In acetonitrile for 9h; Reflux;	88%

trifluoromethane anhydride: trifluoromethane anhydride

: 6470-18-4
1-acetylamino-7-naphthol

: 168901-50-6
2-trifluoromethanesulfonyloxy-8-acetylaminonaphthalene

Conditions

Conditions	Yield
With dmap; trifluoromethanesulfonic acid anhydride In dichloromethane	69.5%

: 141-43-5
ethanolamine

: 6470-18-4
1-acetylamino-7-naphthol

: 1627144-25-5
9-acetylamino-2-hydroxymethyl naphtho[2,1-d]oxazole

Conditions

Conditions	Yield
With copper dichloride In acetonitrile at 60℃; for 15h;	62%

Raw Materials

119-28-8

75-36-5

118-46-7

108-24-7

Downstream Products

13916-98-8

Total:93 Page 1 of 3 1 2 3 Next>>

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Standards and Recommendations

Appearance: Gray powder
Content: 95% min
Purity: 97% min
Alkali insoluble matters: 0.1% max

Specification

The 1-Acetamido-7-hydroxynaphthalene, with the CAS registry number 6470-18-4 and EINECS registry number 229-293-5, has the systematic name of N-(7-hydroxynaphthalen-1-yl)acetamide. And the molecular formula of this chemical is C₁₂H₁₁NO₂. It belongs to the product categories Intermediates of Dyes and Pigments. What's more, it should be used as intermediate of coupling component in neutral stain.

The physical properties of 1-Acetamido-7-hydroxynaphthalene are as following: (1)ACD/LogP: 1.58; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.58; (4)ACD/LogD (pH 7.4): 1.57; (5)ACD/BCF (pH 5.5): 9.3; (6)ACD/BCF (pH 7.4): 9.23; (7)ACD/KOC (pH 5.5): 171.7; (8)ACD/KOC (pH 7.4): 170.41; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 29.54 Å²; (13)Index of Refraction: 1.704; (14)Molar Refractivity: 60.24 cm³; (15)Molar Volume: 155 cm³; (16)Polarizability: 23.88×10^-24cm³; (17)Surface Tension: 59 dyne/cm; (18)Density: 1.297 g/cm³; (19)Flash Point: 247.9 °C; (20)Enthalpy of Vaporization: 78.05 kJ/mol; (21)Boiling Point: 486.2 °C at 760 mmHg; (22)Vapour Pressure: 4.45E-10 mmHg at 25°C.

Preparation of 1-Acetamido-7-hydroxynaphthalene: It can start with alkaline fusion of 1,7-cleve's acid, and gives the 8-amino-2-naphthol sodium salt. Then acidatewith dilute acid, and the 8-amino-2-naphthol will separate out. Acetylize it with acetic anhydride, and gives the desired product.

Preparation of 1-Acetamido-7-hydroxynaphthalene can start with alkaline fusion of 1,7-cleve's acid, and gives the 8-amino-2-naphthol sodium salt. Then acidatewith dilute acid, and the 8-amino-2-naphthol will separate out. Acetylize it with acetic anhydride, and gives the desired product

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(Nc1c2c(ccc1)ccc(O)c2)C
(2)InChI: InChI=1/C12H11NO2/c1-8(14)13-12-4-2-3-9-5-6-10(15)7-11(9)12/h2-7,15H,1H3,(H,13,14)
(3)InChIKey: ALNWQAFPXMGLTJ-UHFFFAOYAR