CAS No.66-81-9,Actidione Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	66-81-9
Name:	Actidione
Article Data:	4

Formula:	C₁₅H₂₃NO₄
Molecular Weight:	281.352
Synonyms:	Glutarimide, 3-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-(7CI,8CI);Naramycin A (6CI);3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide;Acti-Aid;Acti-dione;Actidion;Cicloheximide;Cycloheximide;LDN 97549;NM-MCD 80;NSC 185;Naramycin;Naramycin Microcapsule D 80;Naramycin NM-MCU 80;TZA;U 4527;b-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide;
EINECS:	200-636-0
Density:	1.136 g/cm³
Melting Point:	111-116 °C
Boiling Point:	491.8 °C at 760 mmHg
Flash Point:	251.2 °C
Solubility:	2.1 g/100 mL (2 °C) in water
Appearance:	Off-white to light tan powder
Hazard Symbols:	Xn, T, N, T+
Risk Codes:	22-68-61-51/53-28
Safety:	53-45-61
Transport Information:	UN 2811 6.1/PG 1
PSA:	83.47000
LogP:	1.37030

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Chemistry

Product Name: Actidione (CAS NO.66-81-9)

Molecular Formula: C₁₅H₂₃NO₄
Molecular Weight: 281.35g/mol
Mol File: 66-81-9.mol
EINECS: 200-636-0
Appearance: Off-white to light tan powder
Melting Point: 107-114 ºC
Boiling point: 491.8 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 251.2 °C
Density: 1.136 g/cm³
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, alkali.
Index of Refraction: 1.498
Molar Refractivity: 72.66 cm³
Molar Volume: 247.5 cm³
Surface Tension: 39.9 dyne/cm
Enthalpy of Vaporization: 87.39 kJ/mol
Vapour Pressure: 9.81E-12 mmHg at 25°C
XLogP3-AA: 0.5
H-Bond Donor: 2
H-Bond Acceptor: 4
Structure Descriptors of Actidione (CAS NO.66-81-9):
IUPAC Name: 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
Canonical SMILES: CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C
Isomeric SMILES: C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C
InChI: InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChIKey: YPHMISFOHDHNIV-FSZOTQKASA-N
Product Categories: scellaneous; Antibiotic Explorer; Antifungal; Signalling

Toxicity Data With Reference

1.	skn-rbt 5 mg/24H rns	TXCYAC Toxicology. 14 (1949),117.
2.	skn-rbt 1%/24H MOD	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB-274-414 .
3.	dni-hmn:oth 100 mg/L	BBACAQ Biochimica et Biophysica Acta. 696 (1982),15.
4.	dni-hmn:oth 300 nmol/L	CNREA8 Cancer Research. 44 (1984),2421.
5.	orl-rat LD50:2 mg/kg	UPJOH* “Compounds Available for Fundamental Research, 2 (6),(1971),
6.	ipr-rat LD50:3700 µg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 136 (1962),400.
7.	scu-rat LD50:2500 µg/kg	ANTCAO Antibiotics and Chemotherapy. 10 (1960),682.
8.	ivn-rat LD50:2 mg/kg	ANTCAO Antibiotics and Chemotherapy. 10 (1960),682.
9.	orl-mus LD50:133 mg/kg	UPJOH* “Compounds Available for Fundamental Research, 2 (6),(1971),
10.	ipr-mus LD50:100 mg/kg	CNCRA6 Cancer Chemotherapy Reports. 30 (1963),9.

Consensus Reports

EPA Extremely Hazardous Substances List. EPA Genetic Toxicology Program.

Safety Profile

A poison by ingestion, subcutaneous, intraperitoneal and intravenous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A skin irritant. A pesticide. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes Xn Harmful ,T Toxic ,N Dangerous ,T+ Very
Risk Statements 22-68-61-51/53-28
R22:Harmful if swallowed.
R68:Possible risk of irreversible effects.
R60:May impair fertility.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R28:Very toxic if swallowed.
Safety Statements 53-45-61
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR UN 2811 6.1/PG
WGK Germany 3
RTECS MA4375000
HazardClass 6.1(a)
PackingGroup II

Specification

Actidione , its CAS NO. is 66-81-9, the synonyms are Cycloheximide ; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide ; [1S-[1alpha(S*),3alpha,5beta]]-4-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione .