Products Categories
CAS No.: | 67165-56-4 |
---|---|
Name: | Diclofensine |
Article Data: | 5 |
Molecular Structure: | |
Formula: | C17H17Cl2NO |
Molecular Weight: | 322.234 |
Synonyms: | Ro 8-4650;Diclofensine;4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methylisoquinoline; |
Density: | 1.242 g/cm3 |
Boiling Point: | 422.595 °C at 760 mmHg |
Flash Point: | 209.378 °C |
PSA: | 12.47000 |
LogP: | 4.51720 |
1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol
A
4-(3,4-dichlorophenyl)-5-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
B
Diclofensine
Conditions | Yield |
---|---|
Stage #1: 1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol With sulfuric acid In dichloromethane at 0℃; for 28h; Stage #2: With sodium hydroxide In dichloromethane pH=9; | A 10% B 59% |
Stage #1: 1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol With sulfuric acid In dichloromethane at 0℃; for 28h; Stage #2: With sodium hydroxide In dichloromethane pH=~ 9; | |
Stage #1: 1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol With sulfuric acid In dichloromethane; water at 0℃; for 28h; Stage #2: With sodium hydroxide In dichloromethane; water pH=~ 9; |
1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanone
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / methanol / 2 h / 0 °C 2.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C 2.2: pH ~ 9 View Scheme |
1-(3-methoxyphenyl)-N-methylmethanamine
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dichloromethane / 1 h / 0 °C 1.2: 1 h / 0 °C 2.1: sodium tetrahydroborate / methanol / 2 h / 0 °C 3.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C 3.2: pH ~ 9 View Scheme |
3-methoxy-benzaldehyde
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / methanol; water / 2 h / 0 °C 2.1: dichloromethane / 1 h / 0 °C 2.2: 1 h / 0 °C 3.1: sodium tetrahydroborate / methanol / 2 h / 0 °C 4.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C 4.2: pH ~ 9 View Scheme |
Diclofensine
Conditions | Yield |
---|---|
With CHIRALPAK AD Purification / work up; Resolution of racemate; | |
With Chiralpak AD column In diethylamine; isopropyl alcohol Purification / work up; Resolution of racemate; |
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,2-dichloro-ethane Reflux; |
Diclofensine
A
(-)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
B
(S)-diclofensine
Conditions | Yield |
---|---|
With Chiralpak AD column In n-heptane; diethylamine; isopropyl alcohol Purification / work up; Resolution of racemate; |
Diclofensine
4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C View Scheme |
Diclofensine
7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere 6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C 7: methanol / 1 h / Reflux View Scheme | |
Multi-step reaction with 9 steps 1.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2.1: hydrogen bromide / water; acetic acid / 8 h / Reflux 3.1: pyridine / dichloromethane / 1 h / -78 - 0 °C 4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux 6.1: methanol / 1 h / Reflux 7.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C 8.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication 9.1: hydrogenchloride / ethanol; water / 1 h / 20 °C 9.2: pH 8 - 9 View Scheme |
Diclofensine
tert-butyl 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere 6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C 7: methanol / 1 h / Reflux 8: N,N-dimethyl-formamide / 1 h / 20 °C View Scheme | |
Multi-step reaction with 8 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux 6: methanol / 1 h / Reflux 7: dmap; triethylamine / dichloromethane / 4 h / 20 °C 8: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication View Scheme |
The Diclofensine, with the CAS registry number 67165-56-4, is also known as 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methylisoquinoline. It belongs to the product categories of Intermediates & Fine Chemicals; Pharmaceuticals. This chemical's molecular formula is C17H17Cl2NO and molecular weight is 322.23. What's more, its systematic name is 4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline. It is a stimulant which can inhibits reuptake of dopamine and noradrenaline, and it is also an effective antidepressant.
Physical properties of Diclofensine are: (1)ACD/LogP: 3.685; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.39; (4)ACD/LogD (pH 7.4): 3.09; (5)ACD/BCF (pH 5.5): 1.89; (6)ACD/BCF (pH 7.4): 95.17; (7)ACD/KOC (pH 5.5): 12.25; (8)ACD/KOC (pH 7.4): 615.99; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 12.47 Å2; (13)Index of Refraction: 1.591; (14)Molar Refractivity: 87.614 cm3; (15)Molar Volume: 259.405 cm3; (16)Polarizability: 34.733×10-24cm3; (17)Surface Tension: 42.8289985656738 dyne/cm; (18)Density: 1.242 g/cm3; (19)Flash Point: 209.378 °C; (20)Enthalpy of Vaporization: 67.679 kJ/mol; (21)Boiling Point: 422.595 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: Clc1ccc(cc1Cl)C3c2ccc(OC)cc2CN(C3)C
(2)Std. InChI: InChI=1S/C17H17Cl2NO/c1-20-9-12-7-13(21-2)4-5-14(12)15(10-20)11-3-6-16(18)17(19)8-11/h3-8,15H,9-10H2,1-2H3
(3)Std. InChIKey: ZJDCGVDEEHWEIG-UHFFFAOYSA-N