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69353-21-5

Basic Information
CAS No.: 69353-21-5
Name: Benzofuro[4,3,2-efg][2]benzazocin-2-ol,2,3,3a,8,9,10,11,11b-octahydro-5-methoxy-9-methyl-, hydrobromide (9CI)
Molecular Structure:
Molecular Structure of 69353-21-5 (Benzofuro[4,3,2-efg][2]benzazocin-2-ol,2,3,3a,8,9,10,11,11b-octahydro-5-methoxy-9-methyl-, hydrobromide (9CI))
Formula: C17H21 N O3 . Br H
Molecular Weight: 368.31
Synonyms: Benzofuro[4,3,2-efg]-2-benzazocin-6-ol,1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-, hydrobromide
EINECS: 217-780-5
Density: 1.593 g/cm3
Melting Point: 287oC decomposes
Boiling Point: 630.4 °C at 760 mmHg
Flash Point: 335 °C
Solubility: N/A
Appearance: N/A
Hazard Symbols: ToxicT
Risk Codes: R25
Safety: S45
Transport Information: N/A
PSA: 18.46000
LogP: 3.58460
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Chemistry

Molecular Formula: C17H22BrNO3
Molecular Weight: 290.2681 g/mol
Index of Refraction: 1.741
Density: 1.593 g/cm3
Flash Point: 335 °C
Enthalpy of Vaporization: 98.01 kJ/mol
Boiling Point: 630.4 °C at 760 mmHg
Vapour Pressure: 9.29E-17 mmHg at 25 °C
Storage tempreture: -20 °C
Structure of Galantamine hydrobromide (CAS NO.69353-21-5):
                     
Product Category of Galantamine hydrobromide (CAS NO.69353-21-5): Galantamine

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 9mg/kg (9mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Acta Biologica et Medica Germanica. Vol. 7, Pg. 402, 1961.
mouse LD50 intravenous 5200ug/kg (5.2mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
BEHAVIORAL: EXCITEMENT
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toxicology and Applied Pharmacology. Vol. 3, Pg. 347, 1961.
mouse LD50 oral 18700ug/kg (18.7mg/kg)   Chemical Abstracts. Vol. 66, Pg. 53993v, 1967.
mouse LD50 subcutaneous 15400ug/kg (15.4mg/kg) PERIPHERAL NERVE AND SENSATION: FASCICULATIONS
BEHAVIORAL: TREMOR
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Farmakologiya i Toksikologiya Vol. 25, Pg. 168, 1962.
rat LD50 intravenous 10mg/kg (10mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 32, Pg. 301, 1986.
rat LD50 oral 75mg/kg (75mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 32, Pg. 301, 1986.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Used as a cholinesterase inhibitor. When heated to decomposition it emits very toxic fumes of HBr and NOx.Safety information of Galanthamine hydrobromide (CAS NO.69353-21-5):
Hazard Codes:  ToxicT
Risk Statements: 
25: Toxic if swallowed
Safety Statements: 
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Specification

 Galantamine hydrobromide , its cas register number is 69353-21-5. It also can be called Lycoremine hydrobromide ; and Benzofuro(4,3,2-efg)(2)benzazocin-6-ol, 1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-, hydrobromide .