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CAS No.: | 6946-22-1 |
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Name: | 3-AMINOPHTHALIC ACID HYDROCHLORIDE |
Article Data: | 5 |
Molecular Structure: | |
Formula: | C8H7 N O4 . Cl H |
Molecular Weight: | 217.609 |
Synonyms: | 1,2-Benzenedicarboxylicacid, 3-amino-, hydrochloride (9CI); Phthalic acid, 3-amino-, hydrochloride(6CI,8CI); 3-Aminophthalic acid hydrochloride |
Melting Point: | 182 °C |
Boiling Point: | 436.4°C at 760 mmHg |
Flash Point: | 217.7°C |
Appearance: | off-white to yellow-beige crystalline powder |
Risk Codes: | R36/37/38 |
PSA: | 100.62000 |
LogP: | 2.04840 |
Conditions | Yield |
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With sodium hydroxide; acetic acid; PtO2 In water; acetone | 90% |
With sodium hydroxide; acetic acid; PtO2 In water; acetone | 90% |
Stage #1: 3-nitrophthalic acid With palladium 10% on activated carbon; hydrogen In ethanol at 20 - 25℃; under 1500.15 Torr; for 3h; Autoclave; Stage #2: With hydrogenchloride In acetone at 10℃; Solvent; Pressure; | 65 g |
Stage #1: 3-nitrophthalic acid With palladium on activated charcoal; hydrogen at 55 - 65℃; under 5250.53 - 6750.68 Torr; for 12h; Large scale; Stage #2: With hydrogenchloride In water at -5 - 5℃; for 1h; Large scale; |
Conditions | Yield |
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With hydrogenchloride In water at 25℃; for 15h; | 120 g |
rac-α-aminoglutarimide hydrochloride
3-aminophthalic acid hydrochloride
pomalidomide
Conditions | Yield |
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Stage #1: rac-α-aminoglutarimide hydrochloride; 3-aminophthalic acid hydrochloride In acetonitrile for 0.25h; Stage #2: With triethylamine In water; acetonitrile at 15 - 87℃; for 49.0833 - 50.8333h; Product distribution / selectivity; | 94% |
Stage #1: rac-α-aminoglutarimide hydrochloride; 3-aminophthalic acid hydrochloride In acetonitrile for 0.25h; Stage #2: With 1H-imidazole In water; acetonitrile at 15 - 87℃; for 7.08333 - 10.8333h; Product distribution / selectivity; | 92% |
Stage #1: rac-α-aminoglutarimide hydrochloride; 3-aminophthalic acid hydrochloride With acetic acid In acetonitrile for 0.25h; Stage #2: With 1H-imidazole In water; acetonitrile at 15 - 87℃; for 7.08333 - 10.8333h; Product distribution / selectivity; | 85% |
Stage #1: rac-α-aminoglutarimide hydrochloride; 3-aminophthalic acid hydrochloride With acetic acid In acetonitrile for 0.25h; Stage #2: With triethylamine In water; acetonitrile at 15 - 87℃; for 7.08333 - 10.8333h; Product distribution / selectivity; | 84% |
With acetic acid; triethylamine In acetone at 80 - 85℃; for 6h; | 68.5% |
Conditions | Yield |
---|---|
In sodium hydroxide | 92% |
In sodium hydroxide | 92% |
4-(S)-amino-δ-valerolactam hydrochloride
3-aminophthalic acid hydrochloride
Conditions | Yield |
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With triethylamine In N,N-dimethyl-formamide at 80℃; for 18h; Inert atmosphere; | 47% |
Conditions | Yield |
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With hydrogenchloride In water for 6h; Reflux; | |
With hydrogenchloride In water for 6h; Reflux; |
3-aminophthalic acid hydrochloride
C17H25N5O
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: hydrogenchloride / water / 6 h / Reflux 2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 20 °C 2.2: 15 h / 20 °C View Scheme |
3-aminophthalic acid hydrochloride
Apremilast
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: water / 15 h / 100 °C 2.1: acetic acid / 15 h / Reflux 2.2: 3.25 h / 25 °C / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: 2 h / 110 °C 2.1: acetonitrile / 80 - 85 °C 2.2: 60 - 65 °C View Scheme | |
Multi-step reaction with 2 steps 1: 2 h / 110 °C 2: acetonitrile / 3 h / Reflux View Scheme |