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| CAS No.: | 69610-40-8 |
|---|---|
| Name: | (S)-(-)-1-Boc-2-pyrrolidinemethanol |
| Article Data: | 231 |
| Molecular Structure: | |
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| Formula: | C10H19NO3 |
| Molecular Weight: | 201.266 |
| Synonyms: | 1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (S)-;(2S)-1-(tert-Butoxycarbonyl)-2-pyrrolidinemethanol;(2S)-2-Hydroxymethylpyrrolidine-1-carboxylic acid tert-butyl ester;(2S)-Hydroxymethylpyrrolidine-1-carboxylicacid tert-butyl ester;(S)-(+)-N-Boc-prolinol;(S)-(-)-1-(tert-Butoxycarbonyl)-2-pyrrolidinemethanol;(S)-1-BOC-2-Pyrrolidinemethanol;(S)-2-(Hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester;(S)-N-tert-Butoxycarbonyl-2-pyrrolidinemethanol;(S)-tert-Butyl2-(hydroxymethyl)pyrrolidine-1-carboxylate;1-BOC-2-(S)-Pyrrolidinemethanol;BOC-L-prolinol;Boc-(S)-(-)-2-pyrrolidinemethanol;N-[(tert-Butoxy)carbonyl]-L-prolinol;tert-Butyl(2S)-2-(Hydroxymethyl)-1-pyrrolidinecarboxylate; |
| EINECS: | -0 |
| Density: | 1.084 g/cm3 |
| Melting Point: | 62-64 °C(lit.) |
| Boiling Point: | 289.5 °C at 760 mmHg |
| Flash Point: | 128.9 °C |
| Solubility: | insoluble in water |
| Appearance: | White powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 49.77000 |
| LogP: | 1.31610 |
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- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 71825-51-92-methyl-2-(4-nitrophenyl)propanenitrile
- 15761-39-4
1-(tert-butoxycarbonyl)-L-proline
- 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol
| Conditions | Yield |
|---|---|
| With borane-THF In tetrahydrofuran at 0 - 20℃; | 100% |
| With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 5h; | 100% |
| With borane-THF at 0℃; for 1h; | 99% |
- 24424-99-5
di-tert-butyl dicarbonate
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
- 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol
| Conditions | Yield |
|---|---|
| With triethylamine In ethyl acetate at 0 - 20℃; for 11.5h; | 100% |
| With triethylamine In ethyl acetate at 0 - 20℃; for 11.5h; | 100% |
| With sodium hydrogencarbonate In tetrahydrofuran; water at 0 - 20℃; Inert atmosphere; | 100% |
- 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol
| Conditions | Yield |
|---|---|
| With tert.-butylnitrite; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In chlorobenzene at 100℃; under 760.051 Torr; for 2h; | 95% |
| With tert.-butylnitrite; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In monoethylene glycol diethyl ether at 120℃; under 1500.15 Torr; for 2h; | 93% |
| With 4,4'-bipyridine; (phthalocyaninato)iron(II); oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 80℃; under 3000.3 Torr; for 18h; Pressure; Autoclave; | 91% |
- 59936-29-7
(S)-N-(tert-butoxycarbonyl)proline methyl ester
- 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol
| Conditions | Yield |
|---|---|
| With lithium borohydride In tetrahydrofuran at 20℃; | 97% |
| With lithium aluminium tetrahydride In diethyl ether | 95% |
| With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 1h; | 95% |
- 69610-41-9
Boc-L-Pro-H
- 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate In methanol at 0 - 20℃; for 0.333333h; | 93% |
| With sodium tetrahydroborate In ethanol for 0.75h; | 86% |
| With sodium tetrahydroborate In methanol at 20℃; for 1.5h; | 80% |
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
- 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol
| Conditions | Yield |
|---|---|
| With triethylamine In water; ethyl acetate | 80.8% |
- 288086-98-6
[tert-butyl (R)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate]
- 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol
| Conditions | Yield |
|---|---|
| Stage #1: With sodium borohydride; lithium chloride In tetrahydrofuran; ethanol at 0℃; for 0.416667h; Stage #2: [tert-butyl (R)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate] at 0 - 20℃; for 18h; Stage #3: With acetic acid In water |
- 147-85-3
L-proline
- 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: lithium aluminium hydride / tetrahydrofuran / 0 - 25 °C 2: 39.1 g / tetrahydrofuran / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1: 75 percent / LiAlH4 / tetrahydrofuran 2: NaOH View Scheme | |
| Multi-step reaction with 2 steps 1: LiAlH4 / tetrahydrofuran 2: NaCl, NaHCO3 / CHCl3; H2O / Heating View Scheme |
- 15761-39-4
1-(tert-butoxycarbonyl)-L-proline
- 541-41-3
chloroformic acid ethyl ester
- 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol
| Conditions | Yield |
|---|---|
| With sodium borohydrid; sodium hydrogencarbonate; triethylamine; silica gel In tetrahydrofuran |
- 135097-23-3
(2S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester
- 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 16h; | 96% |
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Chemistry
IUPAC Name: (S)-(-)-1-Boc-2-pyrrolidinemethanol
Molecular Formula: C10H19NO3
Molecular Weight: 201.26
Density: 1.084 g/cm3
Melting Point: 60-64 ºC
Boiling Point: 289.5 °C at 760 mmHg
Flash Point: 128.9 °C
Solubility: insoluble
Freely Rotating Bonds: 4
Polar Surface Area: 38.77 Å2
Index of Refraction: 1.483
Molar Refractivity: 53.05 cm3
Molar Volume: 185.5 cm3
Polarizability: 21.03× 10-24 cm3
Surface Tension: 39.1 dyne/cm
Enthalpy of Vaporization: 61.36 kJ/mol
Vapour Pressure: 0.000241 mmHg at 25°C
Storage temperature: store at 0°C
Properties: white powder
The Cas Register Number of Boc-L-Prolinol is 69610-40-8.The chemical synonyms of Boc-L-Prolinol (CAS NO.69610-40-8) are 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S)- ; tert-Butyl (2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate ; tert-Butyl-(2S)-2-(hydroxymethyl)pyrrolidin-1-carboxylat ; (R)-(-)-N-Boc-prolinol ; (S)-(-)-1-Boc-2-pyrrolidinemethanol ; (S)-(+)-2-(Hydroxymethyl)pyrrolidine, N-BOC protected ; (S)-1-Boc-2-pyrrolidinemethanol ; (S)-2-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester ; (S)-tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate ; 1-Boc-L-Prolinol ; 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester ; Boc-L-Prolinol ; Boc-Pro-ol ; N-(tert-Butoxycarbonyl)-D-prolinol ; N-(tert-Butoxycarbonyl)-L-prolinol ; N-Boc-L-Prolinol ; N-t-BOC-L-Prolinol ; tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate .Product categories of Boc-L-Prolinol (CAS NO.69610-40-8) are Alcohol Aldehyde and acid series ; Amino Acids ; Chiral Building Blocks ; Glycidyl Compounds, etc. (Chiral) ; Synthetic Organic Chemistry ; Chiral chemicals ; Chiral Products .The molecular structure of Boc-L-Prolinol (CAS NO.69610-40-8) is.png)
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Uses
Boc-L-Prolinol (CAS NO.69610-40-8) is used as pharmaceutical intermediate.
Production
Its raw materials are Dichloromethane ; Di-tert-butyl dicarbonate ; L-(+)-Prolinol .Preparation products are Boc-L-beta-Homoproline ; N-BOC-L-Prolinal by Boc-L-Prolinol (CAS NO.69610-40-8) .
Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Irritant