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Basic Information
| CAS No.: | 704-10-9 |
|---|---|
| Name: | 2,4-Dichloro-5-fluoroacetophenone |
| Molecular Structure: | |
|
|
|
| Formula: | C8H5Cl2FO |
| Molecular Weight: | 207.032 |
| Synonyms: | Acetophenone,2',4'-dichloro-5'-fluoro- (7CI,8CI); |
| EINECS: | -0 |
| Density: | 1.388 g/cm3 |
| Melting Point: | 33-36 °C |
| Boiling Point: | 254.9 °C at 760 mmHg |
| Flash Point: | 107.9 °C |
| Appearance: | white to light yellow cryst. low melting solid |
| Hazard Symbols: |
 Xi, F
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36-37/39 |
| PSA: | 17.07000 |
| LogP: | 3.33510 |
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Synthetic route
- 1435-48-9
1,3-dichloro-4-fluorobenzene
- 75-36-5
acetyl chloride
- 704-10-9
2,4-dichloro-5-fluoroacetophenone
Conditions
| Conditions | Yield |
|---|---|
| With aluminum (III) chloride at 110℃; Reagent/catalyst; Temperature; | 89.3% |
| With aluminum (III) chloride Friedel Crafts acylation; | 52% |
| With aluminum (III) chloride at 30 - 120℃; Product distribution / selectivity; | |
| aluminum (III) chloride |
- 1435-48-9
1,3-dichloro-4-fluorobenzene
- 108-24-7
acetic anhydride
- 704-10-9
2,4-dichloro-5-fluoroacetophenone
Conditions
| Conditions | Yield |
|---|---|
| With aluminium trichloride | |
| With aluminum (III) chloride at 70 - 120℃; for 25h; | 165 g |
- 704-10-9
2,4-dichloro-5-fluoroacetophenone
Conditions
| Conditions | Yield |
|---|---|
| With hydrogenchloride for 0.5h; |
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 1-butyl-3-methylimidazolium*BF4; 1,3-bis(diphenylphosphino)propane; Et3N / Ni(OAc)2 / 30 h / 130 °C 2: aq. HCl / 0.5 h View Scheme |
Conditions
| Conditions | Yield |
|---|---|
| With hydrogenchloride; acetic anhydride; aluminium trichloride |
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: nitric acid; sulfuric acid / 2 h / 95 - 100 °C 2.1: potassium fluoride / 3 h / 140 - 150 °C 2.2: 7 h / 165 - 170 °C 3.1: chlorine / 8 h / 170 - 180 °C 4.1: aluminum (III) chloride / 110 °C View Scheme |
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: potassium fluoride / 3 h / 140 - 150 °C 1.2: 7 h / 165 - 170 °C 2.1: chlorine / 8 h / 170 - 180 °C 3.1: aluminum (III) chloride / 110 °C View Scheme |
- 704-10-9
2,4-dichloro-5-fluoroacetophenone
- 86522-89-6
2,4-dichloro-5-fluoro-benzoic acid
Conditions
| Conditions | Yield |
|---|---|
| With oxygen; nitric acid In water; acetic acid at 70℃; under 1500.15 Torr; for 0.15h; Catalytic behavior; Temperature; Time; Pressure; Flow reactor; Industrial scale; Green chemistry; | 99.9% |
| With sodium hypochlorite In 1,4-dioxane | 98% |
| With sodium hydroxide; chlorine In ethanol pH=10; | 90% |
| With sodium percarbonate; potassium tert-butylate; sphingosylphosphorylcholine; meta-dinitrobenzene In tert-butyl alcohol at 80℃; for 5h; | 35% |
| With sodium hydroxide; chlorine In ethanol for 6h; pH=8 - 10; |
- 704-10-9
2,4-dichloro-5-fluoroacetophenone
Conditions
| Conditions | Yield |
|---|---|
| With chlorine In water | 96% |
- 704-10-9
2,4-dichloro-5-fluoroacetophenone
- 106809-14-7
2,4-dichloro-5-fluoro-3-nitro-benzoic acid
Conditions
| Conditions | Yield |
|---|---|
| With sulfuric acid; nitric acid at 103 - 110℃; for 3h; Temperature; | 91% |
| With sulfuric acid; nitric acid 1.) 55 deg C; 2.) 75 deg C, 3 h; | 82% |
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2,4-Dichloro-5-fluoroacetophenone
Chemistry
Synonyms:2',4'-Dichloro-5'-Fluoroacetophenone 2,4-Dichloro-5-Fluoroacetophenone;2',4'-Dichloro-5'-fluoroacetophenone 98%;2',4'-Dichloro-5'-fluoroacetophenone98% ; 2',4'-DICHLORO-5'-FLUOROACETOPHENONE;1-(2,4-DICHLORO-5-FLUORO-PHENYL)-ETHANONE;2',4'-DICHLORO-5'-FLUOROACETOPHENONE, 90;2,4-DICHLORO-5-FLUOROACETOPHENONE;1-(2,4-DICHLORO-5-FLUOROPHENYL)ETHAN-1-ONE;
The Molecular formula of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9) : C8H5Cl2FO
The Molecular Weight of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9) : 207.03
Molecular Structure :
Melting point: 33-36 °C
Boiling point:167 °C(lit.)
Flash point: >230 °F
density: 1.425 g/mL at 25 °C(lit.)
refractive index: n20/D 1.546(lit.)
The Molecular formula of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9) : C8H5Cl2FO
The Molecular Weight of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9) : 207.03
Molecular Structure :
Melting point: 33-36 °C
Boiling point:167 °C(lit.)
Flash point: >230 °F
density: 1.425 g/mL at 25 °C(lit.)
refractive index: n20/D 1.546(lit.)
Uses
2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9) is used as pharmaceutical intermediates.
Safety Profile
The Hazard Codes of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9): 
Xi, 
F
Hazard Note: Flammable
The Risk Statements information of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
Xi, F Hazard Note: Flammable
The Risk Statements information of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3