CAS No.7059-24-7,CHROMOMYCIN A3 Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	7059-24-7
Name:	CHROMOMYCIN A3

Formula:	C57H82 O26
Molecular Weight:	1183.39
Synonyms:	ChromomycinA3 (8CI); Olivomycin D, 3D-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-a-L-arabino-hexopyranosyl)-7-methyl-;Aburamycin B; Antibiotic B 599; CMA3; NSC 58514; Toyomycin
Density:	1.43g/cm³
Melting Point:	185℃
Boiling Point:	1147.6°C at 760 mmHg
Flash Point:	311.1°C
Hazard Symbols:	T+,T
Risk Codes:	61-28
Safety:	A deadly poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and fumes.
PSA:	359.34000
LogP:	1.54640

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Chemistry

Chemistry informtion about Chromomycin A3 (CAS NO.7059-24-7) is:
IUPAC Name: [(2S,3S,4S,6S)-6-[(2R,3R,4R,6S)-6-[(2R,3R,4R,6S)-6-[[(2S,3S)-6-[(2S,4R,5S,6R)-5-acetyloxy-4-[(2R,4R,5R,6R)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-8,9-dihydroxy-7-methyl-1-oxo-3,4-dihydro-2H-anthracen-2-yl]oxy]-3-hydroxy-2-methyloxan-4-yl]oxy-3-hydroxy-2-methyloxan-4-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] acetate ; [(2S,3S,4S)-6-[(2S,3S,4S)-6-[(2R,3R,4R)-6-[[(2S,3S)-6-[(4S,5R,6S)-5-acetyloxy-4-[(4S,5S,6S)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-[(1R,3S,4S)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-8,9-dihydroxy-7-methyl-1-oxo-3,4-dihydro-2H-anthracen-2-yl]oxy]-3-hydroxy-2-methyloxan-4-yl]oxy-3-hydroxy-2-methyloxan-4-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] acetate
Synonyms: Aburamycinb ; Antibiotic69895a ; Antibioticb599 ; Chromomycina(Sub3) ; Nosyl)-7-Methyl- ; Nsc-58514 ; Olivomycind,3b-O-(4-O-Acetyl-2,6-Dideoxy-3-C-Methyl-Alpha-L-Arabinohexopyra ; Toyomycin
MF: C₅₇H₈₂O₂₆
MW: 1183.25
EINECS: 230-348-0
Density: 1.46 g/cm³
Flash Point: 321.3 °C
Boiling Point: 1177.4 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Enthalpy of Vaporization: 182.51 kJ/mol
Storage temp.: 2-8°C
Merck: 13,2258
Following is the molecular structure of Chromomycin A3 (CAS NO.7059-24-7) is:

Uses

Chromomycin A3 (CAS NO.7059-24-7) can be used as Membrane-impermeant G/C-specific fluorescent DNA-binding dye, Antibacterial antibiotic ,Antitumor antibiotic that inhibits RNA synthesis, especially in solid tumors.Also, it is useful for the detection of protamine deficiency in sperm chromatin.

Toxicity Data With Reference

1.	dnr-bcs 800 ng/plate	TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. 44 (1985),96.
2.	dnd-hmn:hla 400 µg/L	CNREA8 Cancer Research. 45 (1985),2813.
3.	msc-hmn:hla 8 µg/L	CNREA8 Cancer Research. 45 (1985),2813.
4.	msc-mus:emb 25 µg/L	CNREA8 Cancer Research. 45 (1985),2813.
5.	ipr-rat LDLo:250 µg/kg	85ERAY Antibiotics: Origin, Nature, and Properties. 2 (1978),1401.
6.	orl-mus LD50:1431 µg/kg	NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .
7.	ipr-mus LD50:800 µg/kg	JAJAAA Journal of Antibiotics, Series A. 16 (1963),22.
8.	scu-mus LD50:2800 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),245.
9.	ivn-mus LD50:1 mg/kg	JAJAAA Journal of Antibiotics, Series A. 16 (1963),22.
10.	ipr-dog LDLo:250 µg/kg	85ERAY

Safety Profile

A deadly poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and fumes.
Safty information about Chromomycin A3 (CAS NO.7059-24-7) :
Hazard Codes：
Very T+
Toxic T
Risk Statements：
R61:May cause harm to the unborn child.
R28:Very toxic if swallowed.
Safety Statements:
S53:Avoid exposure - obtain special instructions before use.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3462 6.1/PG 1
WGK Germany: 3
RTECS: GB7875000
F:
F 3: Hygroscopic.
F 8: Photosensitive.
F 10: Keep under argon.
HazardClass: 6.1(a)
PackingGroup: I

Specification

Chromomycin A3 (CAS NO.7059-24-7) is a glycosidic antibiotic produced at the fermentation of a strain of Streptomyces griseus. It is also called toyomycin.An antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. Serves as a fluorescent DNA stain. The compound blocks macromolecule synthesis by a specific, reversible interaction with DNA in the presence of bivalent metal ions. Binding to DNA minor groove mediates an efficient competitive inhibition of DNA gyrase and significantly affects topoisomerase II activity.