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72-43-5

Basic Information
CAS No.: 72-43-5
Name: Benzene,1,1'-(2,2,2-trichloroethylidene)bis[4-methoxy-
Article Data: 20
Cas Database
Molecular Structure:
Molecular Structure of 72-43-5 (Benzene,1,1'-(2,2,2-trichloroethylidene)bis[4-methoxy-)
Formula: C16H15 Cl3 O2
Molecular Weight: 345.653
Synonyms: Ethane,1,1,1-trichloro-2,2-bis(p-methoxyphenyl)- (8CI);1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane;1,1,1-Trichloro-2,2-bis(p-methoxyphenyl)ethane;1,1,1-Trichloro-2,2-di(4-methoxyphenyl)ethane;1,1-Bis(p-methoxyphenyl)-2,2,2-trichloroethane;2,2,2-Trichloro-1,1-bis(4-methoxyphenyl)ethane;2,2-Bis(4-methoxyphenyl)-1,1,1-trichloroethane; 2,2-Bis(p-methoxyphenyl)-1,1,1-trichloroethane;2,2-Di-p-anisyl-1,1,1-trichloroethane;4,4'-(2,2,2-Trichloroethylidene)dianisole; DMDT;Di(p-methoxyphenyl)(trichloromethyl)methane; Dimethoxy-DDT; Marlate; Mesox K;Methoxcide; Methoxy-DDT; Methoxychlor; Metox; Metox plynny; Mezox K; NSC 8945;p,p'-DMDT; p,p'-Dimethoxydiphenyltrichloroethane; p,p'-Methoxychlor
EINECS: 200-779-9
Density: 1.4 g/cm3
Melting Point: 86-88 °C(lit.)
Boiling Point: greater than or equal to 100 °C.
Flash Point: less than 60 degrees C
Solubility: In water, 0.1 mg/l @ 25 deg C
Appearance: COLOURLESS TO LIGHT YELLOW CRYSTALS , WITH CHARACTERISTIC ODOUR.
Hazard Symbols: Toxic material. TLV: TWA 10 mg/m3; not classifiable as a human carcinogen.
Risk Codes: 20/21/22-40
Safety: Suspected carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Moderately toxic by intraperitoneal and skin contact routes. Human systemic effects by skin contact: somnolence. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits highly toxic fumes of Cl. See also DDT and CHLOROPHENOLS.
Transport Information: N/A
PSA: 18.46000
LogP: 5.20590
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Chemistry

Other names:Methoxcide,Dimethoxy-DDT,Methoxy-DDT
Molecular formula:C16H15Cl3O2
Molar mass:345.65 g mol-1
Melting point:87 °C, 360 K, 189 °F
Boiling point:decomposes

Uses

Methoxychlor is a synthetic organochlorine used as an insecticide.

Toxicity Data With Reference

1.   

spm-rat-orl 28 g/kg/10W-C

   PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 176 (1984),187.
2.   

cyt-ham-ipr 50 mg/kg

   ARTODN    Archives of Toxicology. 58 (1985),152.
3.   

orl-rat TDLo:18,200 mg/kg/2Y-C:CAR,TER

   EVHPAZ    EHP, Environmental Health Perspectives. Subseries of DHEW Publications. 36 (1980),205.
4.   

orl-mus TDLo:56,700 mg/kg/90W-C:CAR,TER

   JCROD7    Journal of Cancer Research and Clinical Oncology. 93 (1979),173.
5.   

orl-rat TD:80 g/kg/2Y-C:CAR,TER

   LIFSAK    Life Sciences. 24 (1979),1367.
6.   

orl-rat TD:72,800 mg/kg/2Y-C:CAR

   EVHPAZ    EHP, Environmental Health Perspectives. Subseries of DHEW Publications. 36 (1980),205.
7.   

orl-hmn LDLo:6430 mg/kg

   PCOC**    Pesticide Chemicals Official Compendium ,Association of the American Pesticide Control Officials, Inc.(Topeka, KS.: )1966,705.
8.   

skn-hmn TDLo:2414 mg/kg:CNS

   PCOC**    Pesticide Chemicals Official Compendium ,Association of the American Pesticide Control Officials, Inc.(Topeka, KS.: )1966,705.
9.   

orl-rat LD50:5000 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 99 (1950),140.
10.

Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal No Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 20 ,1979,p. 259.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 5 ,1974,p. 193.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-35 ,1978. . EPA Genetic Toxicology Program. Community Right-To-Know List.

Safety Profile

Suspected carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Moderately toxic by intraperitoneal and skin contact routes. Human systemic effects by skin contact: somnolence. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits highly toxic fumes of Cl. See also DDT and CHLOROPHENOLS.

Standards and Recommendations

OSHA PEL: TWA Total Dust: 10 mg/m3; 5 mg/m3
ACGIH TLV: TWA 10 mg/m3; Not Classifiable as a Human Carcinogen
DFG MAK: 15 mg/m3