CAS No.72657-23-9,(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Suppliers

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Basic Information

CAS No.:

72657-23-9

Name:

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER

Article Data:

Molecular Structure:

Formula:

C5H10 O3

Molecular Weight:

118.133

Synonyms:

Propanoic acid,3-hydroxy-2-methyl-, methyl ester, (R)-; (-)-Methyl b-hydroxyisobutyrate; (2R)-3-Hydroxy-2-methylpropionicacid methyl ester; (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester;(R)-3-Hydroxy-2-methylpropionic acid methyl ester;(R)-3-Hydroxy-2-methylpropionic acid methyl ester; Methyl(2R)-3-hydroxy-2-methylpropanoate; Methyl (2R)-3-hydroxy-2-methylpropionate;Methyl (R)-(-)-3-hydroxy-2-methylpropionate; Methyl(R)-(-)-3-hydroxy-2-methylpropionate; Methyl (R)-3-hydroxy-2-methylpropanoate;Methyl (R)-3-hydroxy-2-methylpropionate; Methyl (R)-3-hydroxyisobutanoate;Methyl (R)-b-hydroxyisobutyrate; R-(-)-Rocheester

Density:

1.066

Boiling Point:

76-77 °C12 mm Hg(lit.)

Flash Point:

80 ºC

Appearance:

Clear Colorless Oil

Hazard Symbols:

R10:;

Risk Codes:

R10

Safety:

Risk Statements	10
Safety Statements	16
WGK Germany	3

PSA:

46.53000

LogP:

-0.21220

Synthetic route

: C16H24O3Si

: 72657-23-9
methyl (R)-3-hydroxy-2-methylpropionate

Conditions

Conditions	Yield
With hydrogen; palladium 10% on activated carbon	88%

: 186581-53-3, 908094-01-9
diazomethane

: 1910-47-0
(2R)-3-hydroxy-2-methylpropanoic acid

: 72657-23-9
methyl (R)-3-hydroxy-2-methylpropionate

Conditions

Conditions	Yield
In diethyl ether	86%

: 56850-58-9, 59965-24-1, 74924-27-9, 112068-34-5
methyl (2R)-3-(benzyloxy)-2-methylpropanoate

: 72657-23-9
methyl (R)-3-hydroxy-2-methylpropionate

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In methanol at 50℃; Industrial scale;	84%

: 212051-35-9
(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate

: 72657-23-9
methyl (R)-3-hydroxy-2-methylpropionate

Conditions

Conditions	Yield
With t-butyl bromide In acetonitrile for 0.833333h; Reflux; chemoselective reaction;	72%

: 15484-46-5
methyl 2-hydroxymethylacrylate

: 72657-23-9
methyl (R)-3-hydroxy-2-methylpropionate

Conditions

Conditions	Yield
With glucose dehydrogenase; potassium phosphate; D-glucose; ene reductase YqjM wild type enzyme; NADPH In 2-methyltetrahydrofuran; aq. phosphate buffer at 30℃; pH=7.5; Reagent/catalyst; Inert atmosphere; Enzymatic reaction; enantioselective reaction;	58%
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (Rc,Ra)-THNAPhos; hydrogen In dichloromethane at 20℃; under 7500.75 Torr; for 24h; optical yield given as %ee;
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 1-(3-(diphenylphosphanyl)phenyl)urea; (2S)-methyl (S)-2-(3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-ylamino)-2-isobutylethanoate; hydrogen In dichloromethane at 24.84℃; under 7500.75 Torr; for 16h;

: methyl (2R,5S,E)-5-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpent-3-enoate

: 72657-23-9
methyl (R)-3-hydroxy-2-methylpropionate

Conditions

Conditions	Yield
Stage #1: methyl (2R,5S,E)-5-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpent-3-enoate With ozone In methanol at -78℃; Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃;	48%

: 186581-53-3, 908094-01-9
diazomethane

: 1910-47-0, 2068-83-9, 26543-05-5, 44520-17-4
3-hydroxyisobutyric acid

A: 80657-57-4
3-hydroxy-(2S)-methylpropionate

B: 72657-23-9
methyl (R)-3-hydroxy-2-methylpropionate

Conditions

Conditions	Yield
In diethyl ether Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 15484-46-5
methyl 2-hydroxymethylacrylate

A: 80657-57-4
3-hydroxy-(2S)-methylpropionate

B: 72657-23-9
methyl (R)-3-hydroxy-2-methylpropionate

Conditions

Conditions	Yield
With hydrogen; {(-)-1,2-bis(2R,5R)-2,5-dimethylphospholanobenzene(cyclooctadiene)rhodium(l)} triflate In methanol at 30℃; under 3000.3 Torr; Product distribution; Further Variations:; Catalysts;
With hydrogen; Ru(cod)(η3-methylallyl)2/(R)-SYNPHOS/HBF4 In methanol at 50℃; under 15001.5 Torr; for 23h; Title compound not separated from byproducts.;
With hydrogen; p-benzoquinone; [RuH(η6-cycloocta-1,3,5-triene)(S)-SYNPHOS]BF4 In methanol at 15℃; under 15001.5 Torr; for 23h; Title compound not separated from byproducts.;

: 64809-29-6
methyl 3-hydroxy-2-methylpropanoate

A: 80657-57-4
3-hydroxy-(2S)-methylpropionate

B: 72657-23-9
methyl (R)-3-hydroxy-2-methylpropionate

Conditions

Conditions	Yield
With [Rh(dppb)(COD)]BF4; hydrogen In methanol at 20℃; under 45004.5 Torr; for 20h;
With capillary column subsequently coated with 1) Co(d-Cam)1/2(bdc)1/2(tmdpy) (d-Cam=d-camphoric acid,bdc=1,4-benzenedicarboxylic acid, tmdpy=4,4’-trimethylenedipyridine), 2) peramylated β-cyclodextrin at 93℃; Reagent/catalyst; Resolution of racemate;

: 110-87-2
3,4-dihydro-2H-pyran

: 72657-23-9
methyl (R)-3-hydroxy-2-methylpropionate

: 88557-53-3
(R)-2-Methyl-3-(tetrahydro-pyran-2-yloxy)-propionic acid methyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In tetrahydrofuran Ambient temperature;	100%
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; Inert atmosphere;	100%
With toluene-4-sulfonic acid In diethyl ether at 20℃;	99%

Raw Materials

Downstream Products

Total:97 Page 1 of 3 1 2 3 Next>>

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Chemistry

Molecular structure of Methyl (R)-(-)-3-hydroxy-2-methylpropionate (CAS NO.72657-23-9) is:

Product Name: Methyl (R)-(-)-3-hydroxy-2-methylpropionate
CAS Registry Number: 72657-23-9
IUPAC Name: methyl 3-Hydroxy-2-methylpropanoate
Molecular Weight: 118.1311 [g/mol]
Molecular Formula: C₅H₁₀O₃
XLogP3-AA: -0.1
H-Bond Donor: 1
H-Bond Acceptor: 3
Refractive index: n20/D 1.425
Storage temp.: 2-8 °C
Surface Tension: 33.218 dyne/cm
Density: 1.051 g/cm³
Flash Point: 81.111 °C
Enthalpy of Vaporization: 47.893 kJ/mol
Boiling Point: 175.048 °C at 760 mmHg
Vapour Pressure: 0.361 mmHg at 25 °C

Uses

Methyl (R)-(-)-3-hydroxy-2-methylpropionate (CAS NO.72657-23-9) can be used in chiral derivative of 3-Hydroxyisobutyrate.

Safety Profile

Safty information about Methyl (R)-(-)-3-hydroxy-2-methylpropionate (CAS NO.72657-23-9) is:
Risk Statements: 10
R10:Flammable.
Safety Statements: 16
S16:Keep away from sources of ignition.
WGK Germany: 3

Specification

Methyl (R)-(-)-3-hydroxy-2-methylpropionate , its cas register number is 72657-23-9. It also can be called Propanoic acid,3-hydroxy-2-methyl-, methyl ester, (2R)- ; (-)-Methyl D-beta-hydroxyisobutyrate .It is a clear colorless oil.