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72956-09-3

Basic Information
CAS No.: 72956-09-3
Name: Carvedilol
Molecular Structure:
Molecular Structure of 72956-09-3 (Carvedilol)
Formula: C24H26N2O4
Molecular Weight: 406.48 .
Synonyms: 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+-)-;Carvedilolum [Latin];Carvedilol [USAN:BAN:INN:JAN];Coreg (TN);Carvedilol (JAN/USAN);2-Propanol,1-(9H-carbazol-4-yloxy)-3-[[2- (2-methoxyphenoxy)ethyl]amino]-;SKF 105517;(+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol;DQ 2466;1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;
EINECS: 1308068-626-2
Density: 1.25 g/cm3
Melting Point: 113-117 °C
Boiling Point: 655.2 °C at 760 mmHg
Flash Point: 350.1 °C
Solubility: 449.2ug/L(22.5 oC)
Appearance: colourless crystalline powder
Hazard Symbols: HarmfulXn, DangerousN
Risk Codes: 51/53-36/37/38-20/21/22
Safety: 61-36-26
Transport Information: UN 3077 9/PG 3
PSA: 75.74000
LogP: 4.12890
Synthetic route
787598-91-8

(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate

A

918903-20-5

C39H39N3O6

B

72956-09-3

carvedilol

Conditions
ConditionsYield
With sodium hydroxide In water; isopropyl alcohol at 50 - 70℃; for 0.75h;A n/a
B 91.21%
Stage #1: (+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate With triethylamine In ethyl acetate at 10 - 35℃; for 1h;
Stage #2: With sodium chloride In water; ethyl acetate for 0.5h;
180987-80-8

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one

72956-09-3

carvedilol

Conditions
ConditionsYield
With sodium hydroxide In propan-1-ol at 60℃; for 4h; Solvent; Temperature;89.11%
With sodium hydroxide In ethanol Reflux; Inert atmosphere;70%
With ethanol; sodium hydroxide Inert atmosphere; Reflux;70%
1016214-10-0

(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol tolsylate

72956-09-3

carvedilol

Conditions
ConditionsYield
With sodium carbonate In water; ethyl acetate Product distribution / selectivity;88%
With sodium carbonate In water; ethyl acetate80%
With sodium hydroxide; water In isopropyl alcohol Product distribution / selectivity;
72955-94-3

1-[benzyl[2(2-methoxyphenoxy)ethyl]amino]-3-(9H-carbazol-4-yloxy)propan-2-ol

72956-09-3

carvedilol

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In water; ethyl acetate at 20 - 50℃; for 8h;84%
With hydrogen; palladium 10% on activated carbon In methanol at 70℃; under 2942.29 - 4413.43 Torr;76.7%
With hydrogen; 5%-palladium/activated carbon In ethyl acetate at 60 - 70℃; under 2574.5 - 3310.08 Torr; for 10h;
143412-40-2, 143412-41-3, 72955-96-5

1-amino-3-(9H-carbazol-4-yloxy)-propan-2-ol

53815-60-4

1-(2-chloroethoxy)-2-methoxybenzene

72956-09-3

carvedilol

Conditions
ConditionsYield
With potassium carbonate In toluene at 80 - 85℃;83%
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

51997-51-4

4-(2,3-epoxypropoxy)carbazole

72956-09-3

carvedilol

Conditions
ConditionsYield
In isopropyl alcohol for 5h; Inert atmosphere; Reflux;81%
With N-ethyl-N,N-diisopropylamine In 1,2-dimethoxyethane at 80 - 85℃;36.26%
With sulfuric acid; potassium carbonate In isopropyl alcohol at 80℃; for 6h;

4-[2-(tert-butyldiphenylsilyloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propyloxy]carbazole

72956-09-3

carvedilol

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 30 - 40℃; for 17h;67%
72956-09-3

(+/-) 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethyl]amino-2-propanol oxalate

72956-09-3

carvedilol

Conditions
ConditionsYield
With ammonia In dichloromethane; water at 20℃; for 1h; pH=9.0 - 9.3;63.2%
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

51997-51-4

4-(2,3-epoxypropoxy)carbazole

A

918903-20-5

C39H39N3O6

B

72956-09-3

carvedilol

Conditions
ConditionsYield
In dimethyl sulfoxide at 68 - 72℃; for 18 - 20h;A n/a
B 58%
64464-07-9

2-[(2-methoxy)phenoxy]ethylamine hydrochloride

51997-51-4

4-(2,3-epoxypropoxy)carbazole

72956-09-3

carvedilol

Conditions
ConditionsYield
Stage #1: 2-[(2-methoxy)phenoxy]ethylamine hydrochloride With sodium hydroxide In water at 20℃; pH=9 - 9.5;
Stage #2: 4-(2,3-epoxypropoxy)carbazole In water at 80 - 85℃; for 0.75 - 1h; Product distribution / selectivity;
45.99%
Stage #1: 2-[(2-methoxy)phenoxy]ethylamine hydrochloride With sodium hydroxide In water; isopropyl alcohol at 20℃; pH=9 - 9.5;
Stage #2: 4-(2,3-epoxypropoxy)carbazole In water; isopropyl alcohol for 4 - 5h; Product distribution / selectivity; Heating / reflux;
43.05%
With potassium carbonate In i-Amyl alcohol at 80 - 85℃; for 7h;41%
With calcium carbonate In isopropyl alcohol at 80℃; for 4h;
51997-51-4

4-(2,3-epoxypropoxy)carbazole

72956-09-3

carvedilol

Conditions
ConditionsYield
Stage #1: 2-[(2-methoxy)phenoxy]ethylamine hydrochloride With potassium carbonate In isopropyl alcohol at 35℃; for 0.25h;
Stage #2: 4-(2,3-epoxypropoxy)carbazole In isopropyl alcohol at 83℃; for 5h;
45%
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 140 °C
2: methylamine / water / 2 h / 80 °C
3: potassium carbonate / toluene / 80 - 85 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride / water; methanol / 0 - 30 °C
2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 - 95 °C
3: methylamine / water / 2 h / 80 °C
4: dipotassium hydrogenphosphate; N-benzyl-N,N,N-triethylammonium chloride / toluene / 5 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: 4-methoxypyridine N-oxide; sodium sulfate / dichloromethane / 60 h / 20 °C
2: potassium carbonate / toluene / 60 h / Reflux
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 30 - 40 °C
View Scheme
Multi-step reaction with 2 steps
1: water; hydrogen bromide / isopropyl alcohol / 25 - 60 °C
2: triethylamine / isopropyl alcohol / 60 °C
View Scheme
787598-91-8

(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate

72956-09-3

carvedilol

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol Product distribution / selectivity;
374779-43-8

(±)-1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol sulfate

72956-09-3

carvedilol

Conditions
ConditionsYield
With sodium carbonate In water; ethyl acetate Product distribution / selectivity;
1187921-88-5

C27H34N2O4Si

72956-09-3

carvedilol

Conditions
ConditionsYield
Stage #1: C27H34N2O4Si With phosphoric acid; water In ethyl acetate at 20 - 25℃;
Stage #2: With ammonia In water; ethyl acetate pH=~ 9.5; Product distribution / selectivity;
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

1187921-94-3

1-(9H-carbazol-4-yloxy)-3-bromopropan-2-ol

72956-09-3

carvedilol

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol at 60℃; Product distribution / selectivity;
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

1187921-93-2

1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol

72956-09-3

carvedilol

Conditions
ConditionsYield
With potassium carbonate In toluene at 80 - 85℃; for 13h; Product distribution / selectivity;
52602-39-8

9H-carbazol-4-ol

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water; dimethyl sulfoxide / 12 h / 25 - 45 °C
2: 1,2-dimethoxyethane; ethyl acetate
View Scheme
Multi-step reaction with 5 steps
1.1: pyridine / isopropyl alcohol / 0.17 h / Inert atmosphere
1.2: 16 h / 15 - 20 °C / Inert atmosphere
2.1: pyridine / dichloromethane / 12 h / 5 - 20 °C / Inert atmosphere
3.1: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere
4.1: 100 - 110 °C / Inert atmosphere
5.1: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: pyridine / isopropyl alcohol / 0.17 h / Inert atmosphere
1.2: 16 h / 15 - 20 °C / Inert atmosphere
2.1: dichloromethane / 4 h / 0 °C / Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere
4.1: 100 - 110 °C / Inert atmosphere
5.1: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
1187921-93-2

1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine / dichloromethane / 12 h / 5 - 20 °C / Inert atmosphere
2: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere
3: 100 - 110 °C / Inert atmosphere
4: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 4 steps
1: dichloromethane / 4 h / 0 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere
3: 100 - 110 °C / Inert atmosphere
4: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 - 95 °C
2: methylamine / water / 2 h / 80 °C
3: dipotassium hydrogenphosphate; N-benzyl-N,N,N-triethylammonium chloride / toluene / 5 h / Reflux
View Scheme
1392322-33-6

3-((9H-carbazol-4-yloxy)methyl)-3-chloropropane-2-yl phenyl carbonate

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere
2: 100 - 110 °C / Inert atmosphere
3: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme

1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol chloroformate

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere
2: 100 - 110 °C / Inert atmosphere
3: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dmap / N,N-dimethyl-formamide / 15 - 30 °C / Inert atmosphere
2: 100 - 110 °C / Inert atmosphere
3: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere
2: 100 - 110 °C / Inert atmosphere
3: ethanol; sodium hydroxide / Inert atmosphere; Reflux
View Scheme
1218777-33-3

5-((9H-carbazol-4-yloxy)methyl)-oxazolidin-2-one

53815-60-4

1-(2-chloroethoxy)-2-methoxybenzene

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25 h / 25 - 100 °C / Inert atmosphere
2: sodium hydroxide / ethanol / 12 h / Reflux; Inert atmosphere
View Scheme
1392100-68-3

1-(9H-carbazol-4-yloxy)-3-(benzhydrylamino)propan-2-ol

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon / methanol / 6 h / 3102.97 - 3620.13 Torr / Inert atmosphere
2: 0 °C / Reflux; basic condition; Inert atmosphere
3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25 h / 25 - 100 °C / Inert atmosphere
4: sodium hydroxide / ethanol / 12 h / Reflux; Inert atmosphere
View Scheme
143412-40-2, 143412-41-3, 72955-96-5

1-amino-3-(9H-carbazol-4-yloxy)-propan-2-ol

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 0 °C / Reflux; basic condition; Inert atmosphere
2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25 h / 25 - 100 °C / Inert atmosphere
3: sodium hydroxide / ethanol / 12 h / Reflux; Inert atmosphere
View Scheme
1218777-33-3

5-((9H-carbazol-4-yloxy)methyl)-oxazolidin-2-one

1187921-84-1

1-(2-iodoethoxy)-2-methoxybenzene

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C
2: water; sodium hydroxide / ethanol / 12 h / Reflux
View Scheme
90-05-1

2-methoxy-phenol

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrabutylammomium bromide; sodium hydroxide / water / 5 h / 80 °C
2: sodium iodide / acetone / 48 h / Reflux
3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C
4: water; sodium hydroxide / ethanol / 12 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide; tetrabutylammomium bromide / water / 0.25 h / 30 °C
1.2: 20 - 70 °C
2.1: sodium hydroxide / toluene / 0.17 h / 25 - 30 °C
2.2: 25 - 30 °C
3.1: dipotassium hydrogenphosphate; N-benzyl-N,N,N-triethylammonium chloride / toluene / 5 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: tetrabutylammomium bromide; sodium hydroxide / 16 h / Reflux
2: water; sodium hydroxide / 13 h / 130 °C
3: ethyl acetate / 24 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: tetrabutylammomium bromide; sodium hydroxide / 16 h / Reflux
2: tetrabutylammomium bromide / 180 - 185 °C
3: water; potassium hydroxide / 13 h / 130 °C
4: ethyl acetate / 24 h / Reflux
View Scheme
53815-60-4

1-(2-chloroethoxy)-2-methoxybenzene

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium iodide / acetone / 48 h / Reflux
2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C
3: water; sodium hydroxide / ethanol / 12 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: water; sodium hydroxide / 13 h / 130 °C
2: ethyl acetate / 24 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: tetrabutylammomium bromide / 180 - 185 °C
2: water; potassium hydroxide / 13 h / 130 °C
3: ethyl acetate / 24 h / Reflux
View Scheme
1207276-96-7

sodium salt of 9H-carbazol-4-ol

72956-09-3

carvedilol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 48 h / 100 °C
2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 36 h / 100 °C
3: water; sodium hydroxide / ethanol / 12 h / Reflux
View Scheme
72956-09-3

carvedilol

C24H22(2)H4N2O4

Conditions
ConditionsYield
With deuterium In tetrahydrofuran under 1500.15 Torr; for 24h; Glovebox; Heating;99%
72956-09-3

carvedilol

1-(carbazol-4-yloxy)-3-[[2-(O-methoxyphenoxy)ethyl]amino]-2-propanol dihydrogen phosphate

Conditions
ConditionsYield
With phosphoric acid In acetonitrile at 20℃; for 0.5h; Product distribution / selectivity;98%
With phosphoric acid In acetone Product distribution / selectivity;98%
With phosphoric acid In methanol Product distribution / selectivity;98%
72956-09-3

carvedilol

374779-45-0

1-(9H-carbazole-4-oxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanolphosphate

Conditions
ConditionsYield
With phosphoric acid In water; acetonitrile at 20 - 70℃; Product distribution / selectivity;97%
With phosphoric acid In water; N,N-dimethyl-formamide; isopropyl alcohol at 20℃; Product distribution / selectivity;96%
With phosphorus pentoxide In water; acetone at 0 - 45℃; Product distribution / selectivity;95%
72956-09-3

carvedilol

24424-99-5

di-tert-butyl dicarbonate

C29H34N2O6

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 1h;96%
72956-09-3

carvedilol

carvedilol dihydrogen phosphate hemihydrate

Conditions
ConditionsYield
With phosphorus pentoxide In water; acetone at 0 - 45℃; for 1h; Product distribution / selectivity;95%
With hydrogenchloride; dipotassium hydrogenphosphate In water; acetone at 0 - 45℃; for 1h; pH=4.5 - 5; Product distribution / selectivity;94.49%
With PPA In water; acetone at 0 - 45℃; for 1h; Product distribution / selectivity;93.3%
72956-09-3

carvedilol

530-62-1

1,1'-carbonyldiimidazole

180987-80-8

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 5h;93%
With triethylamine In dichloromethane at 20℃;
72956-09-3

carvedilol

(+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol sulfate salt

Conditions
ConditionsYield
With sulfuric acid In ethanol; water92.1%
With sulfuric acid In water; acetone at 17 - 35℃; for 10 - 24h;
72956-09-3

carvedilol

320401-51-2

2'-(((2S,3R,4S,5S)-3,4,5-triacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yloxy)carbonylamino)biphenyl-2-carboxylic acid

A

1015-89-0

6(5H)-phenanthridinone

B

(2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-{[3-(9H-carbazol-4-yloxy)-2-hydroxy-propyl]-[2-(2-methoxy-phenoxy)-ethyl]-carbamoyloxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethaneA n/a
B 92%
72956-09-3

carvedilol

374779-43-8

(±)-1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol sulfate

Conditions
ConditionsYield
With sulfuric acid In ethanol; water89.6%
With sulfuric acid In dichloromethane; water pH=4.0 - 4.5;
With sulfuric acid In water; acetone at 17 - 35℃; for 10 - 24h;
72956-09-3

carvedilol

616-38-6

carbonic acid dimethyl ester

C26H26N2O5

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 95℃; for 18h;77%
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 95℃; for 18h; Product distribution / selectivity;75%
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 95℃;
72956-09-3

carvedilol

4-cyano-N,N,N-trimethylanilinium trifluoromethansulfonate

C31H29N3O4

Conditions
ConditionsYield
Stage #1: carvedilol With potassium tert-butylate In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 0.166667h; Inert atmosphere; Schlenk technique;
Stage #2: 4-cyano-N,N,N-trimethylanilinium trifluoromethansulfonate In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 3h; Inert atmosphere; Schlenk technique;
71%
72956-09-3

carvedilol

76-05-1

trifluoroacetic acid

8-chlorocarvedilol

Conditions
ConditionsYield
With glucose dehydrogenase; alpha-D-glucopyranose; maltose binding protein-RebF; RebH variant 4-V; nicotinamide adenine dinucleotide; flavin adenine dinucleotide; sodium chloride In methanol at 25℃; for 72h; pH=7.4; Enzymatic reaction;69%
72956-09-3

carvedilol

77-92-9

citric acid

623113-70-2

carvedilol monocitrate monohydrate

Conditions
ConditionsYield
With water In acetone at 20 - 40℃; Product distribution / selectivity;67%
With water In acetone at 20 - 40℃; for 24 - 48h; Product distribution / selectivity;67%
With water
With water Product distribution / selectivity;
72956-09-3

carvedilol

105-58-8

Diethyl carbonate

180987-80-8

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: carvedilol In methanol
Stage #2: With methanol; sodium In methanol
Stage #3: Diethyl carbonate In methanol for 12h; Product distribution / selectivity; Heating / reflux;
65%
72956-09-3

carvedilol

3582-05-6

trifluoromethyl trifluoromethanesulfonate

180987-80-8

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one

Conditions
ConditionsYield
In acetonitrile at 20℃; for 1h; Sealed tube;61%
72956-09-3

carvedilol

852995-78-9

carvedilol mandelate

Conditions
ConditionsYield
In methanol; water; acetone at 17 - 35℃; for 10 - 24h;54.5%
In methanol; water; acetone at 17 - 35℃; for 10 - 24h;54.5%
72956-09-3

carvedilol

74-88-4

methyl iodide

72956-35-5

1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]methylamino}-2-propanol

Conditions
ConditionsYield
Stage #1: carvedilol With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h;
Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃; for 4h;
54%
With sodium hydride In tetrahydrofuran at 20℃; for 4h;54%
In tetrahydrofuran at 20℃;
72956-09-3

carvedilol

74-88-4

methyl iodide

C26H30N2O4

Conditions
ConditionsYield
Stage #1: carvedilol With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h;
Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 4h;
49%
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  • carvedilol

  • Casno:

    72956-09-3

    carvedilol

    Min.Order: 10000 Gram

    FOB Price:  USD $ 1300.0-1300.0/Gram

    Sleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric

    Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of

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    Tel:86-0311-66561638

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  • 72956-09-3  Carvedilol

  • Casno:

    72956-09-3

    72956-09-3 Carvedilol

    Min.Order: 1 Gram

    FOB Price:  USD $ 40.0-50.0/Gram

    1.good quality 1) good quality is the basic of our goal; 2) we can offer samples to be tested; 3) 98% of our products have exported to uk, usa, germany, spain, australia, middle east and many other countries. 4) Good feedback of quality from our cu

    Mulei (Wuhan) New Material Technology Co. Ltd is a scientific and technological company integrating product research and development, manufacture and trading of chemical intermedia

  •  WUHAN MULEI NEW MATERIAL CO., LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8619831967063

    Address:Office1201#, Block C, Hanjie Headquarters International Plaza, Zhongbei Rd, Wuchang District, Wuhan

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  • Carvedilol

  • Casno:

    72956-09-3

    Carvedilol

    Min.Order: 10 Milligram

    FOB Price:  USD $ 0.0-0.0/Milligram

    1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

    Founded in 2011, Amadis Chemical Company Limited is an innovative manufacturer of chemical products and technical service providers. Our business includes sales, manufacture, and s

  •  Amadis Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-89925085

    Address:Watts Cosine.No.166.Xiangmao Road.

       Inquiry Now

  • Bulk Carvedilol Powder

  • Casno:

    72956-09-3

    MSDS/COA Download

    Bulk Carvedilol Powder

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-1.0/Kilogram

    1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery by well-reputed shipping lines. 4.Trial order is available for testing after samples. 5.We will inform you all the information at every stage in advance. 6.P

    Shaanxi greenyo biotech co., ltd is one specialized company which engaged in the naturalplant extracts, pharmaceutical intermediates, chemical raw materials research and developmen

  •  Shaanxi Greenyo Biotech Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-29-81772657

    Address:Gaoxin 4th road, High-tech zone,

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  • Carvedilol

  • Casno:

    72956-09-3

    Carvedilol

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA.Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Active pharmaceutical ingredients(APIs), Veterinary, Indole derivatives, Aro

    Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Fine chemicals, Active pharmaceutical ingredients(APIs), Veterinary, In

  •  Chemwill Asia Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:021-51086038

    Address:High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China

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  • Carvedilol

  • Casno:

    72956-09-3

    Carvedilol

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 1.0-2.0/Metric Ton

    CAS No. [72956-09-3] Chemical Name 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]- 2-Propanol Packing 1-5kgs/ fiber carton(drum) Packing as the need of customer Stan

    Welcome to Henan Sinotech! Sinotech Corporation has exceptional sourcing ability for chemicals used in Organic Fine Chemicals and APIs; Inorganic chemicals; Flame Retardants;OLED

  •  Henan Sinotech Import&Export Corporation

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-371-86181678

    Address:No. 260, Dongming Road,Jinshui District

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  • Cheap Carvedilol 99% 50KG in stock

  • Casno:

    72956-09-3

    Cheap Carvedilol 99% 50KG in stock

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    TianYuan Pharmaceutical Co.,Limited was established in December 2009 for Hongkong. We are a leading high-tech enterprise expertised in researching, developing and manufacturing innovative and generic drugs on anticancer, anti-HIV, anti-tumor, an

    Tianyuan pharmaceutical company in Zhangjiang Eastern has built 500 square meters of pilot laboratories, equipped with two sets of 50L glass reactor, four sets of 100L double react

  •  Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-755-23284190

    Address:B302,2 unit, Jin Lian Building, No. 134 Qianjin 2 Road, Taoyuan village, Xixiang Street, Baoan,Shenzhen,China

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  • Carvedilol

  • Casno:

    72956-09-3

    Carvedilol

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.9-1.0/Kilogram

    LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

    LIDE PHARMACEUTICALS LIMITED is one of the fastest growing pharmaceutical company in China. We have developed strategic partnership with our manufacturing associates having state o

  •  LIDE PHARMACEUTICALS LIMITED

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-25-58409506

    Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.

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  • TIANFU-CHEM CAS:72956-09-3 Carvedilol

  • Casno:

    72956-09-3

    TIANFU-CHEM CAS:72956-09-3 Carvedilol

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Carvedilol Basic information Product Name: Carvedilol Synonyms: 1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-2-propano;CARVEDILOL;COREG;DIMITONE;DQ-2466;DILATREND;BM-1419

    Our company engages in Electronic chemicals such as OLED,Photoresist chemical,Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

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  • 99% Pharmaceutical Raw Materials Carvedilol 72956-09-3

  • Casno:

    72956-09-3

    99% Pharmaceutical Raw Materials Carvedilol 72956-09-3

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

    Hubei Xinrunde Chemical Co., Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredient(s)

  •  Hubei XinRunde Chemical Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+8618874586545

    Address:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China

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  • New production CAS 72956-09-3 with best quality

  • Casno:

    72956-09-3

    New production CAS 72956-09-3 with best quality

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 139.0-210.0/Kilogram

    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is (Wen Xi Pharma), including three subs

  •  Zhuozhou Wenxi import and Export Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

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  • BLOOM TECH Advanced API/Technology support Carvedilol CAS 72956-09-3

  • Casno:

    72956-09-3

    MSDS/COA Download

    BLOOM TECH Advanced API/Technology support Carvedilol CAS 72956-09-3

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Inquiry guide 1.Please send the quantity(Weight) to us, we will arrange our sales to provide the one-for-one service for you. 2.Then we will provide the professional quotation list for you, it will be including all the factors in who

    WHO WE ARE 1.We Focus on the technology of Organic Synthesis since 2008. 2.API/Pharmaceutical intermediate/Fine chemical/New material/Extraction etc. 3.Chemical reagent: Over 300,0

  •  Shaanxi BLOOM TECH Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-29-86470566

    Address:Block A of Central Mansion, No.113 of Weiyang Rd, ETDZ, Xi'an, Shaanxi 710016, China

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  • Carvedilol casno 72956-09-3 China supplier with best price

  • Casno:

    72956-09-3

    MSDS/COA Download

    Carvedilol casno 72956-09-3 China supplier with best price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    Why choose us 1. Extensive expertise in API business 2. Flexible business way 3. A good troubleshooter/very positive attitude for after service 4. Stock availability 5. Strong backup of facotry: high R&D ability, favorable

    HUBEI AOKS BIO-TECH CO.,LTD is located in Hubei province of China.We specialized in Active pharmaceutical ingredient,pharmaceutical intermediates,veterinary drug intermediates and

  •  HUBEI AOKS BIO-TECH CO.,LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-27-52345788

    Address:28F,China Construction Third Bureau,Wuhan,Hubei Province, China

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  • Chinese manufacturer supply Carvedilol CAS 72956-09-3 with favorable price

  • Casno:

    72956-09-3

    Chinese manufacturer supply Carvedilol CAS 72956-09-3 with favorable price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 300.0-300.0/Kilogram

    1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Powder Storage:Store at +4°C Package:1kg/foil bag; 1kg/

    Wuhan Fortuna Chemical Co., Ltd, located in the predominant Wu Han City where is a traffic hinge of China, is a big integrative chemical enterprise being engaged in producing and

  •  Wuhan Fortuna Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-27-59207850

    Address:A2705,Dong Yi Shi Qu,129# XinHua Road,WuHan,China

       Inquiry Now

  • Carvedilol 72956-09-3

  • Casno:

    72956-09-3

    Carvedilol 72956-09-3

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

    Shanghai Upbio Tech Co.,Ltd (Former Onchem (China)Co.,Ltd) is a comprehensive manufacturer and an international distribution of chemicals throughout the world, The predecessor of

  •  Shanghai Upbio Tech Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-21-52196435

    Address:No.2 Floor,No.979 Yunhan Rd,Nicheng,Pudong New Area,Shanghai,China

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  • Manufacturer of Carvedilol at Factory Price

  • Casno:

    72956-09-3

    Manufacturer of Carvedilol at Factory Price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    1. One of the domestic largest manufacturers of API; 2. High quality,competitive price and delivery in time; 3. Supplier of safe and ecofriendly products ; 4. Stable supply and efficient service; 5. Cooperate with scientific

    TNJ is a chemical company since 2001. Our specialization, your confidence-we keep committing to meet the needs of markets and customers with our innovative technology and high stab

  •  Hefei TNJ chemical industry co.,ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-551-65418695

    Address:B911 Xincheng Business Center, Qianshan Road, Hefei Anhui China

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  • Blocker, Carvedilol CAS:72956-09-3

  • Casno:

    72956-09-3

    Blocker, Carvedilol CAS:72956-09-3

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 52.1-58.3/Kilogram

    Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

    Baoji Guokang Healthchem co.,ltd located in Baoji High-tech Zone,is epitomizing international,cooperative and honest.We are a young company full of action and energy,and our profes

  •  Baoji Guokang Healthchem co.,ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-917-3909592

    Address:China

       Inquiry Now

  • Carvedilo CAS NO.72956-09-3

  • Casno:

    72956-09-3

    Carvedilo CAS NO.72956-09-3

    Min.Order: 100 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    we are a professional chemical raw materials manufacturer and exporter for many years. Company advantage: 1.Strict raw material selection 2.Mature production process 3.Perfect quality control system 4.Intimate servcie 5.Competitive pri

    We, Jilin Tely Imp & Exp Co., Ltd. mainly supply and export products including: pharmaceutical raw materials,Chemical reagents, Food additives, pharmaceutical and pesticide interme

  •  Jilin Tely Imp.& Exp.Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-431-81915458

    Address:Room 302, 47 Changping Street, Chaoyang District, Changchun, Jilin Province,China

       Inquiry Now

  • Carvedilol factory

  • Casno:

    72956-09-3

    Carvedilol factory

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers. Our advantages:1, High quality with competitive price:1) Standard:BP/USP/EP/Enterprise standard2) All Purity≥99%3) We are manufacturer

    Shaanxi Mingqi Chemical Co., Ltd is committed to the development of import and export trade in the production, operation and plant extracts of pharmaceutical raw materials and inte

  •  Shaanxi Mingqi Chemical Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:18092428356

    Address:Weiyang District

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  • High quality Carvedilol cas 72956-09-3

  • Casno:

    72956-09-3

    High quality Carvedilol cas 72956-09-3

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 100.0-150.0/Kilogram

    Our company: Wuhan Monad Medicine Tech Co.,LTD is a research and development, production, sales in one high-tech company, own about 100 kinds of products, can provide about more than 30000 kinds of products.

    Wuhan Monad Medicine Tech Co.,LTD is a research and development, production, sales in one high-tech company, own about 100 kinds of products, can provide about more than 30000 kind

  •  Wuhan Monad Medicine Tech Co.,LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8613397160123

    Address:13th Floor, Tower B, Century Plaza, Zhongnan Road, Wuchang District, Wuhan, China.

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  • Carvedilol CAS 72956-09-3 powder

  • Casno:

    72956-09-3

    Carvedilol CAS 72956-09-3 powder

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 10.0-20.0/Metric Ton

    Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1)

    Hebei Guanlang Biotechnology Co., Ltd. belongs to Guanlang Group,which was founded in 2007 , located in Shijiazhuang city which is the capital of Hebei Province and hub sector amon

  •  Hebei Guanlang Biotechnology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8619930503256

    Address:No.66, Yuhua West Road

       Inquiry Now

  • Carvedilol

  • Casno:

    72956-09-3

    Carvedilol

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Henan Coreychem co., LTD focus on high complex new type intermediates and fine chemical custom synthesis,scale-up production and rare chemicals trade.Product category including Intermediates&API,Catalyst and Electronic Chemicals.Covering 811 sq

    Career Henan Chemical Co, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded t

  •  Career Henan Chemical Co

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-371-86658258

    Address:Building 10 of Innovation Park, East District of the National University Science Park

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  • Carvedilol/BM 14190

  • Casno:

    72956-09-3

    Carvedilol/BM 14190

    Min.Order: 1 Gram

    FOB Price:  USD $ 100.0-200.0/Gram

    We are a leading provider and manufacturer of pharmaceutical and chemical products. Mainly involves API, pharmaceutical intermediates, polypeptide, and natural extract etc。We are capable to supply you with any quantity of the mentioned products wit

    Wuhan Prominence Bio-technology Co., Ltd is a leading provider and manufacturer of pharmaceutical and chemical products. Mainly involves API, pharmaceutical intermediates peptides

  •  Wuhan Prominence Bio-technology Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 18327075275

    Address:wuhan

       Inquiry Now

  • Carvedilol

  • Casno:

    72956-09-3

    Carvedilol

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

    Shanghai BetterBioChem Co., Ltd. specializes in research, production of APIs, building blocks and key pharmaceutical intermediates. We provide our products from milligrams to kilog

  •  Shanghai BetterBioChem Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-18013506594

    Address:No. 8 Building, 18 nong, Xi Yingnan Road, Pudong, Shanghai,China

       Inquiry Now

  • Carvedilol

  • Casno:

    72956-09-3

    Carvedilol

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-100000.0/Kilogram

    Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

    AFINE CHEMICALS LIMITED is specialized in the fine chemicals and pharmaceuticals and we have enjoyed great popularity in world markets. Since 2005, we have been rapidly growing to

  •  Afine Chemicals Limited

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-85134551

    Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China

       Inquiry Now

  • CAS.72956-09-3 CARVEDILOL USP

  • Casno:

    72956-09-3

    CAS.72956-09-3 CARVEDILOL USP

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    We have one R&D laboratory and two product bases in Hangzhou which are established as per GMP requirements. Our technical force is rich and has a passel of technologists who have engaged in research and production of medication for ma

    Hangzhou Maytime Bio-Tech Co.,Ltd. specialize in R&D, manufacturing and selling kinds of pharmaceutical raw material, veterinary products, pharmaceutical intermediates. Our techni

  •  Hangzhou Maytime Bio-Tech Co.,Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86-571-88925295 88920965

    Address:No.1-2-801 Nanan Mingzhu Xiaoshan Economical and Technological Development Zone,Hangzhou ,Zhejiang,China

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  • High purity&Low price 72956-09-3 Carvedilol

  • Casno:

    72956-09-3

    High purity&Low price 72956-09-3 Carvedilol

    Min.Order: 1 Gram

    FOB Price:  USD $ 100.0-100.0/Gram

    Specification Name Carvedilol Cas No. 72956-09-3 MF C24H26N2O4 MW 406.47 Purity 99% Apperance white powder

    Shandong Bolode BIO-Technology Co.LTD is a professional company which engaged in the R&D and manufacture of Pharmaceuticals intermediates and Chemical Raw materials. The company is

  •  Shandong Bolode Bio-Technology Co., LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-0531-58966870

    Address:136 Jingyi Road,Huaiyin District,Jinan,Shandong,China

       Inquiry Now

  • Carvedilol 72956-09-3

  • Casno:

    72956-09-3

    Carvedilol 72956-09-3

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:72956-09-3

    Hangzhou Jinlan Pharm-Drugs Technology Co.,Ltd is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pudon

  •  Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86-571-85829053

    Address:Rm A606, Fuyi Center, jianqiao street, Jianggan Area

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  • Carvedilol

  • Casno:

    72956-09-3

    Carvedilol

    Min.Order: 100 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

    Triumph International Development Limilted is engaged in the API, pharmaceutical intermediates research and developmen.Adhering to the "customer first" business philosophy,we suppl

  •  Triumph International Development Limilted

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-536-7971999

    Address:Yinhai Road,Shouguang

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  • High Purity Carvedilol

  • Casno:

    72956-09-3

    High Purity Carvedilol

    Min.Order: 1 Gram

    FOB Price:  USD $ 1.0-5.0/Gram

    Strong backup of facotry: high R&D ability, favorable quality and competitive price 2. Stock avaliability 3. Flexible business way, like payment term and product delivery 4. Fast response 24*7 5. A good troubleshooter/very positive atti

    Beijing Yibai Biotechnology Co., Ltd, backed up with factory toppest support with high R&D ability, we have confidence to make you more competitive on market. Yibai is devoting fo

  •  Beijing Yibai Biotechnology Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-010-60404860

    Address:Xuhui Plaza, Shunyi district, Beijing

       Inquiry Now

  • Carvedilol

  • Casno:

    72956-09-3

    Carvedilol

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

    Shandong Hanjiang Chemical Co., Ltd. is located in Qilu Petrochemical Industrial Park, Zibo City, Shandong Province, involving pesticide, medicine, chemical industry, coating, dy

  •  Shandong Hanjiang Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:18369939125

    Address:95A, Xingyuan East Road, Zhangdian District

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  • Carvedilol

  • Casno:

    72956-09-3

    Carvedilol

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

    J&H Chemical is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other

  •  Hangzhou J&H Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-87396432

    Address:No.200 Zhenhua Rd.Xihu Industrial Park, Hangzhou 310030, China

       Inquiry Now

  • High Quality Carvedilol

  • Casno:

    72956-09-3

    High Quality Carvedilol

    Min.Order: 1 Gram

    FOB Price:  USD $ 1.0-1.0/Gram

    Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc. Our Labo

    SHANDONG SIGMACHEMICAL is mainly engaged in R&D, manufacturing and marketing pharmaceuticals, chemical intermediates, Biochemicals, Veterinary medicines and Nutrition products. Wit

  •  Qingdao Sigma Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

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Chemistry

Structure of Carvedilol (CAS NO.72956-09-3): 

IUPAC Name: 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol 
Empirical Formula: C24H26N2O4
Molecular Weight: 406.4742g/mol
Index of Refraction: 1.657
Molar Refractivity: 119.59 cm3
Molar Volume: 325.1 cm3
Polarizability: 47.41×10-24cm3
Surface Tension: 53.9 dyne/cm
Density: 1.25 g/cm3
Flash Point: 350.1 °C
Enthalpy of Vaporization: 101.39 kJ/mol 
Melting Point: 113-117°C
Boiling Point: 655.2 °C at 760 mmHg
Vapour Pressure: 4.63E-18 mmHg at 25°C 
Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Adrenoceptor 
Canonical SMILES: COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O
InChI: InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
InChIKey: OGHNVEJMJSYVRP-UHFFFAOYSA-N

Uses

 Carvedilol (CAS NO.72956-09-3) is a beta blocker and an alpha blocker indicated in the treatment of mild to moderate congestive heart failure (CHF).

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1gm/kg (1000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.
mouse LD50 intraperitoneal 364mg/kg (364mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
mouse LD50 intravenous 27mg/kg (27mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: OTHER CHANGES
New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
mouse LDLo oral 8gm/kg (8000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.
rat LD50 intraperitoneal 769mg/kg (769mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
rat LD50 intravenous 25mg/kg (25mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: OTHER CHANGES
New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
rat LDLo oral 8gm/kg (8000mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.

Safety Profile

Hazard Codes of Carvedilol (CAS NO.72956-09-3): DangerousN,HarmfulXn
Risk Statements: 51/53-36/37/38-20/21/22
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R36/37/38: Irritating to eyes, respiratory system and skin. 
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 61-36-26
S61: Avoid release to the environment. Refer to special instructions / safety data sheets. 
S36: Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 3077 9/PG 3
RTECS: UA8670000

Specification

 Carvedilol , its cas register number is 72956-09-3. It also can be called (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-
methoxyphenoxy)ethyl)amino)-2-propanol ; (+-)-1-Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol ;
 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+-)- ; BM 14190 ; Carvedilolum ; Coreg ;
 DQ 2466 ; HSDB 7044 ; SKF 105517 ; UNII-0K47UL67F2 . Carvedilol (CAS NO.72956-09-3) is a colourless crystalline solid. Side effects of carvedilol were observed to include nightmares,sleep disturbances and anxiety and panic attacks. This is based on a single case report of a patient already diagnosed with anxiety disorder and using the drug improperly before bedtime at elevated doses.