Products Categories
Basic Information
| CAS No.: | 733039-20-8 |
|---|---|
| Name: | 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine |
| Article Data: | 31 |
| Molecular Structure: | |
|
|
|
| Formula: | C9H11BrClN3 |
| Molecular Weight: | 276.563 |
| Synonyms: | 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine;4-PyriMidinaMine, 5-broMo-2-chloro-N-cyclopentyl-;5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine;N-(5-Bromo-2-chloropyrimidin-4-yl)(cyclopentyl)amine |
| EINECS: | 200-258-5 |
| Density: | 1.643g/cm3 |
| Boiling Point: | 424°C at 760 mmHg |
| Flash Point: | 210.2°C |
| Hazard Symbols: | T |
| Risk Codes: | 25 |
| Safety: | 45 |
| PSA: | 37.81000 |
| LogP: | 3.32000 |
Related products
- 81281-59-67-Benzylideneaminotheophylline
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 90221-55-92-bromo-5-methylbenzaldehyde
- 885590-99-82,3-DIFLUORO-4-IODOBENZALDEHYDE
Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| In 1,4-dioxane at 20℃; for 6h; | 100% |
| With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; for 6h; Inert atmosphere; | 100% |
| With sodium hydrogencarbonate In dichloromethane at 20℃; for 13h; Reagent/catalyst; Solvent; | 97.5% |
- 930-28-9
cyclopentyl chloride
- 205672-25-9
4-amino-5-bromo-2-chloropyrimidine
- 733039-20-8
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
Conditions
| Conditions | Yield |
|---|---|
| With triethylamine In methanol at 20℃; | 92.74% |
| With copper diacetate; sodium hydroxide In dichloromethane at 80℃; for 10h; | 77% |
- 137-43-9
Cyclopentyl bromide
- 205672-25-9
4-amino-5-bromo-2-chloropyrimidine
- 733039-20-8
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
Conditions
| Conditions | Yield |
|---|---|
| With copper(II) trifluoroacetate; sodium hydroxide In 1,4-dioxane at 80℃; for 6h; Reagent/catalyst; Solvent; Temperature; | 90% |
- 36082-50-5
2,4-dichloro-5-bromopyrimidine
- 1003-03-8
Cyclopentamine
A
- 733039-20-8
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
Conditions
| Conditions | Yield |
|---|---|
| With tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane at 20℃; Reagent/catalyst; |
...Expand
- 3724-65-0
2-butenoic acid
- 733039-20-8
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
- 1013916-37-4
2-chloro-5-methyl-8-cyclopentylpyridin[2,3-d]pyrimidin-8-hydro-7-one
Conditions
| Conditions | Yield |
|---|---|
| With triethylamine; palladium dichloride In 1-methyl-pyrrolidin-2-one at 20 - 75℃; for 6h; Temperature; Solvent; Reagent/catalyst; Inert atmosphere; | 94.8% |
| Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine With triethylamine; palladium dichloride In tetrahydrofuran at 60℃; for 5h; Stage #2: 2-butenoic acid In tetrahydrofuran for 2h; Temperature; Reagent/catalyst; Solvent; | 89.08% |
| Stage #1: 2-butenoic acid; 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine With bis(benzonitrile)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine In tetrahydrofuran at 75℃; for 20h; Heck Reaction; Inert atmosphere; Stage #2: In acetic anhydride at 75℃; for 2h; Temperature; Reagent/catalyst; Solvent; | 80% |
| With triethylamine; palladium dichloride In 1-methyl-pyrrolidin-2-one at 75℃; for 6h; Temperature; Inert atmosphere; |
- 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- 733039-20-8
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
- 733038-80-7
tert-butyl 4-(6-{[5-bromo-4-(cyclopentylamino)pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine With potassium carbonate In dichloromethane at 60℃; for 0.5h; Stage #2: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate In dichloromethane at 20 - 60℃; for 1h; | 85% |
| Stage #1: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate; 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine In xylene; butan-1-ol at 100 - 140℃; Stage #2: With sodium hydroxide In water; ethyl acetate; xylene; butan-1-ol |
- 733039-20-8
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
- 74-99-7
prop-1-yne
Conditions
| Conditions | Yield |
|---|---|
| With triphenylphosphine; palladium dichloride In N,N-dimethyl-formamide at 50℃; for 20h; Reagent/catalyst; Solvent; Temperature; | 85% |
- 733039-20-8
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
- 74-88-4
methyl iodide
Conditions
| Conditions | Yield |
|---|---|
| With sodium hydride In tetrahydrofuran for 1.5h; | 84% |
- 733039-20-8
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
- 107-93-7
(E)-but-2-enoic acid
- 1013916-37-4
2-chloro-5-methyl-8-cyclopentylpyridin[2,3-d]pyrimidin-8-hydro-7-one
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine; (E)-but-2-enoic acid With palladium diacetate; triethylamine In 1-methyl-pyrrolidin-2-one at 65℃; Inert atmosphere; Stage #2: With acetic anhydride In 1-methyl-pyrrolidin-2-one at 65℃; Inert atmosphere; | 81% |
| Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine; (E)-but-2-enoic acid With N-ethyl-N,N-diisopropylamine; palladium(II) chloride benzonitrile complex; tris-(o-tolyl)phosphine In tetrahydrofuran at 70℃; for 16h; Stage #2: With acetic anhydride In tetrahydrofuran for 1.5h; | 68% |
- 733039-20-8
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
- 107-19-7
propargyl alcohol
- 1374639-76-5
3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine With copper(l) iodide; palladium on activated charcoal; N-ethyl-N,N-diisopropylamine; bis[2-(diphenylphosphino)phenyl] ether In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Stage #2: propargyl alcohol In tetrahydrofuran for 5.5h; Reflux; Stage #3: With bis[2-(diphenylphosphino)phenyl] ether for 4h; Reflux; | 74.5% |
| With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; N-butylamine In tetrahydrofuran at 29℃; for 20h; Sonogashira Cross-Coupling; Inert atmosphere; Reflux; | 62% |
| Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine; propargyl alcohol With tetrabutyl ammonium fluoride; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran; water at 25 - 67℃; for 2h; Inert atmosphere; Stage #2: With sodium hydrogencarbonate In ethyl acetate | 47.4% |
Hot Products
- 7331-52-4(S)-3-Hydroxy-gamma-butyrolactone
- 7332-18-5Aluminium Sulphate
- 73-34-7Rhaminopyranose, L-
- 73378-73-1Polyoxy(methyl-1,2-ethanediyl), .alpha.,.alpha.,.alpha.-1,2,3-propanetriyltris.omega.-hydroxy-, mixed acrylates and adipates
- 73379-56-3Fructosyltransferase, sucrose 1F-
- 7338-94-5DIPHENYLPROPYNONE
- 73398-42-2trisodium 5-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[[4-[(4-methoxyphenyl)amino]-3-sulphonatophenyl]azo]naphthalene-2,7-disulphonate
- 73398-58-0vegetable-oil, N,N'-hexanediylbis-Amides1,6-Hexandiamine, vegetable oil fatty acids diamide vegetable-oil, n,n'-hexanediylbis-amide Amides,vegetable-oil,N,N'-hexanediylbis- 1,6-Hexandiamine,vegetable oil fatty acids diamide
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
