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7336-36-9

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Basic Information
CAS No.: 7336-36-9
Name: 2-DEMETHYLCOLCHICINE
Article Data: 7
Molecular Structure:
Molecular Structure of 7336-36-9 (2-DEMETHYLCOLCHICINE)
Formula: C21H24NO6
Molecular Weight: 385.417
Synonyms: O2-Demethylcolchicin;2-O-demethylcolchicine;3-demethylcolchicine;
Density: 1.31g/cm3
Melting Point: 125°C
Boiling Point: 766.1°Cat760mmHg
Flash Point: 417.1°C
Safety: Poison by ingestion, intramuscular, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
PSA: 94.09000
LogP: 2.95950
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Chemistry

Product Name: 2-Demethylcolchicine (CAS NO.7336-36-9)


IUPAC: N-[(7S)-2-hydroxy-1,3,10-trimethoxy-9-oxo-6,7-dihydro- 5H-benzo[a]heptalen-7-yl]acetamide
Molecular Formula: C21H23NO6
Molecular Weight: 385.41g/mol
Mol File: 7336-36-9.mol
Boiling point: 766.1 °C at 760 mmHg
Flash Point: 417.1 °C
Density: 1.31 g/cm3
Surface Tension: 56.7 dyne/cm
Enthalpy of Vaporization: 115.46 kJ/mol
Vapour Pressure: 2.63E-24 mmHg at 25°C
XLogP3-AA: 0.5
H-Bond Donor: 2
H-Bond Acceptor: 6

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 16577ug/kg (16.577mg/kg)   Journal of Medicinal Chemistry. Vol. 24, Pg. 257, 1981.
mouse LD50 intraperitoneal 16mg/kg (16mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957.
mouse LD50 oral 19mg/kg (19mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 453, 1953.
rat LDLo intracrebral 75ug/kg (0.075mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957.

Safety Profile

Poison by ingestion, intramuscular, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.

Specification

 2-Demethylcolchicine , its CAS NO. is 7336-36-9, the synonyms are Alkaloid CC 6, from Colchicum cornigerum ; NSC 180533 ; O(sup 2)-Demethylcolchicine ; Acetamide, N-(5,6,7,9-tetrahydro-2-hydroxy-1,3,10-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)- (9CI) ; Colchicine, 3-demethyl- (7CI) ; Colchicine, O(2)-demethyl- (8CI) ; Colchicine, O(sup 2)-demethyl- .