CAS No.734-32-7,Norandrostenedione Suppliers

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Basic Information

Molecular Structure:
CAS No.:	734-32-7
Name:	Norandrostenedione
Article Data:	58
Cas Database

Formula:	C₁₈H₂₄O₂
Molecular Weight:	272.387
Synonyms:	(+)-19-Norandrost-4-en-3,17-dione;(+)-19-Norandrost-4-ene-3,17-dione;(+)-Estr-4-ene-3,17-dione;19-Nor-4-androstenedione;19-Norandrost-4-ene-3,17-dione;3,17-Dioxo-19-norandrost-4-ene;NSC 12164;Nordione;d-19-Norandrost-4-ene-3,17-dione;
EINECS:	211-995-8
Density:	1.13 g/cm³
Melting Point:	?72°C(lit.)
Boiling Point:	433.4 °C at 760 mmHg
Flash Point:	161.8 °C
Solubility:	191mg/L at 20℃
Hazard Symbols:	F, C
Risk Codes:	11-34
Safety:	16-26-36/37/39-45
PSA:	34.14000
LogP:	3.69730

Conditions	Yield
In acetic acid for 1h; Ambient temperature;	96%
With tert.-butylhydroperoxide; 3 A molecular sieve; zircornium(IV) n-propoxide In dichloromethane for 17h;	96%
With zirconium(IV) tert-butoxide; chloral In dichloromethane at 20℃; for 8h;	73%

Specification

The IUPAC name of Estr-4-ene-3,17-dione is (8R,9S,10R,13S,14S)-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione . With the CAS registry number 734-32-7, it is also named as 19-Norandrostenedione ; NSC 12164 ; delta4-Estrene-3,17-dione . The product's categories are steroids, miscellaneous biochemicals, intermediates & fine chemicals and pharmaceuticals.

The Estr-4-ene-3,17-dione is used as Norethindrone intermediate. It was available without prescription in United States until 2005. It was marketed as a prohormone in United States, but it is now classified as a Schedule III drug. Estr-4-ene-3,17-dione is readily metabolized to nandrolone after oral administration, but its potency to transactivate the androgen receptor dependent reporter gene expression is 10 times lower as compared to dihydrotestosterone (DHT).

This product is highly flammable. It can cause burns. Keep away from sources of ignition. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

The other characteristics of this product can be summarized as: (1)ACD/LogP: 2.42 ; (2)# of Rule of 5 Violations: 0 ; (3)ACD/LogD (pH 5.5): 2.42 ; (4)ACD/LogD (pH 7.4): 2.42 ; (5)ACD/BCF (pH 5.5): 40.49 ; (6)ACD/BCF (pH 7.4): 40.49 ; (7)ACD/KOC (pH 5.5): 492.24 ; (8)ACD/KOC (pH 7.4): 492.24 ; (9)#H bond acceptors: 2 ; (10)Index of Refraction: 1.555 ; (11)Molar Refractivity: 77.05 cm³ ; (12)Molar Volume: 239.8 cm³ ; (13)Polarizability: 30.54×10^-24 cm³ ; (14)Surface Tension: 43.3 dyne/cm ; (15)Enthalpy of Vaporization: 68.94 kJ/mol ; (16)Vapour Pressure: 1.03E-07 mmHg at 25°C ; (17)Tautomer Count: 16 ; (18)Exact Mass: 272.17763 ; (19)MonoIsotopic Mass: 272.17763 ; (20)Topological Polar Surface Area: 34.1 ; (21)Heavy Atom Count: 20.

People can use the following data to convert to the molecule structure. SMILES: O=C4/C=C3/CC[C@@H]2[C@H](CC[C@@]1(C(=O)CC[C@H]12)C)[C@H]3CC4; InChI: InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,13-16H,2-9H2,1H3/t13-,14+,15+,16-,18-/m0/s1.

The Estr-4-ene-3,17-dione has many suppliers, such as Emerald-Shanghai Incorporation, Techwin Bio.& Pharm.Technology Limited, Xianju Green Leaf Pharmaceutical Factory and Yangzhou Lianhuan Pharmaceutical Co., Ltd..