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CAS No.: | 739364-95-5 |
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Name: | 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C8H7N3O2 |
Molecular Weight: | 177.162 |
Synonyms: | 2-Methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid;QC-3758;SC1102; |
EINECS: | 1308068-626-2 |
Density: | 1.49±0.1 g/cm3 (20 oC 760 Torr) |
Melting Point: | 238 °C(dec.) |
PSA: | 67.49000 |
LogP: | 0.73590 |
2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid
Conditions | Yield |
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With water; sodium hydroxide at 60℃; Large scale; | 92% |
With sodium hydroxide In tetrahydrofuran at 0℃; for 0.5h; Reagent/catalyst; Solvent; Temperature; | 92.4% |
With lithium hydroxide In tetrahydrofuran; water at 20℃; for 2h; | 85.96% |
2-methylpyrazolo[1,5-a]pyrimidine-6-carbaldehyde
2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid
Conditions | Yield |
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With sodium chlorite; dihydrogen peroxide In water at 50℃; for 1h; Reagent/catalyst; Temperature; Solvent; | 76.7% |
2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid amide
2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid
Conditions | Yield |
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With sodium hydroxide In ethanol at 70℃; for 1h; | 63% |
Stage #1: 2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid amide With potassium hydroxide In ethanol; water at 70℃; for 1h; Stage #2: With hydrogenchloride Further stages; | 63% |
2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid
2-chloro-4,6-dimethoxy-1 ,3,5-triazine
Conditions | Yield |
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With triethylamine In dichloromethane | 95% |
2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 2-methylpyrazolo[1,5-a] pyrimidine-6-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile for 0.5h; Stage #2: (S)-1-[(2-amino-1,1-dimethylethyl)aminoacetyl]pyrrolidine-2-carbonitrile dihydrochloride In acetonitrile at 20℃; for 3h; | 88% |
Stage #1: 2-methylpyrazolo[1,5-a] pyrimidine-6-carboxylic acid With 1,1'-carbonyldiimidazole In dichloromethane at 25 - 35℃; for 4h; Stage #2: (S)-1-[(2-amino-1,1-dimethylethyl)aminoacetyl]pyrrolidine-2-carbonitrile dihydrochloride With triethylamine In dichloromethane at 10 - 35℃; for 2h; | 53.2 g |
2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid
Conditions | Yield |
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With triethylamine; 1,1'-carbonyldiimidazole In dichloromethane at 0 - 20℃; Reagent/catalyst; Solvent; Concentration; Temperature; Large scale; | 87% |
1-hydroxy-pyrrolidine-2,5-dione
2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid
Conditions | Yield |
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With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 8h; Cooling with ice; | 86% |
2,4-Dichloro-6-methoxy-1,3,5-triazine
2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid
Conditions | Yield |
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With pyridine In tetrahydrofuran Solvent; | 84% |
1,3,5-trichloro-2,4,6-triazine
2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid
Conditions | Yield |
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With N-ethyl-N,N-diisopropylamine In tetrahydrofuran Solvent; | 70% |
2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid
Conditions | Yield |
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With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane | 69.3% |