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739364-95-5

Basic Information
CAS No.: 739364-95-5
Name: 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid
Article Data: 6
Molecular Structure:
Molecular Structure of 739364-95-5 (2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid)
Formula: C8H7N3O2
Molecular Weight: 177.162
Synonyms: 2-Methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid;QC-3758;SC1102;
EINECS: 1308068-626-2
Density: 1.49±0.1 g/cm3 (20 oC 760 Torr)
Melting Point: 238 °C(dec.)
PSA: 67.49000
LogP: 0.73590
Synthetic route

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester

739364-95-5

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

Conditions
ConditionsYield
With water; sodium hydroxide at 60℃; Large scale;92%
With sodium hydroxide In tetrahydrofuran at 0℃; for 0.5h; Reagent/catalyst; Solvent; Temperature;92.4%
With lithium hydroxide In tetrahydrofuran; water at 20℃; for 2h;85.96%
933692-37-6

2-methylpyrazolo[1,5-a]pyrimidine-6-carbaldehyde

739364-95-5

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

Conditions
ConditionsYield
With sodium chlorite; dihydrogen peroxide In water at 50℃; for 1h; Reagent/catalyst; Temperature; Solvent;76.7%
338953-49-4

2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid amide

739364-95-5

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 70℃; for 1h;63%
Stage #1: 2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid amide With potassium hydroxide In ethanol; water at 70℃; for 1h;
Stage #2: With hydrogenchloride Further stages;
63%
739364-95-5

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

C13H12N6O4

Conditions
ConditionsYield
With triethylamine In dichloromethane95%
739364-95-5

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

(S)-1-[(2-amino-1,1-dimethylethyl)aminoacetyl]pyrrolidine-2-carbonitrile dihydrochloride

(S)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide

Conditions
ConditionsYield
Stage #1: 2-methylpyrazolo[1,5-a] pyrimidine-6-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile for 0.5h;
Stage #2: (S)-1-[(2-amino-1,1-dimethylethyl)aminoacetyl]pyrrolidine-2-carbonitrile dihydrochloride In acetonitrile at 20℃; for 3h;
88%
Stage #1: 2-methylpyrazolo[1,5-a] pyrimidine-6-carboxylic acid With 1,1'-carbonyldiimidazole In dichloromethane at 25 - 35℃; for 4h;
Stage #2: (S)-1-[(2-amino-1,1-dimethylethyl)aminoacetyl]pyrrolidine-2-carbonitrile dihydrochloride With triethylamine In dichloromethane at 10 - 35℃; for 2h;
53.2 g
739364-95-5

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

C11H20N4O*ClH

(S)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide

Conditions
ConditionsYield
With triethylamine; 1,1'-carbonyldiimidazole In dichloromethane at 0 - 20℃; Reagent/catalyst; Solvent; Concentration; Temperature; Large scale;87%
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

739364-95-5

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

C12H10N4O4

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 8h; Cooling with ice;86%
3638-04-8

2,4-Dichloro-6-methoxy-1,3,5-triazine

739364-95-5

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

C12H9ClN6O3

Conditions
ConditionsYield
With pyridine In tetrahydrofuran Solvent;84%
108-77-0

1,3,5-trichloro-2,4,6-triazine

739364-95-5

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

C11H6Cl2N6O2

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran Solvent;70%
739364-95-5

2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

(2S)-1-{[(1-amino-2-methylpropan-2-yl)amino]acetyl}pyrrolidine-2-carbonitrile methane sulfonate

(S)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane69.3%
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