CAS No.74103-06-3,Ketorolac Suppliers

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Basic Information

Molecular Structure:
CAS No.:	74103-06-3
Name:	Ketorolac
Article Data:	27
Cas Database

Formula:	C₁₅H₁₃NO₃
Molecular Weight:	255.273
Synonyms:	1H-Pyrrolizine-1-carboxylicacid, 5-benzoyl-2,3-dihydro-, (?à)-;1H-Pyrrolizine-1-carboxylicacid, 5-benzoyl-2,3-dihydro-;(+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;(+-)-Ketorolac;
EINECS:	200-001-2
Density:	1.398 g/cm³
Melting Point:	160-161 ºC
Boiling Point:	223.7 ºC at 760 mmHg
Flash Point:	89.1 ºC
Solubility:	183mg/L(32 oC)
Appearance:	white crystalline or white powder
PSA:	59.30000
LogP:	2.29100

Synthetic route

: 157071-66-4
Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

: 74103-06-3
Ketorolac

Conditions

Conditions	Yield
With sodium hydroxide In methanol Ambient temperature;	99%

: ketorolac tromethamine

: 74103-06-3
Ketorolac

Conditions

Conditions	Yield
With hydrogenchloride In water	98%
With hydrogenchloride In water at 0 - 20℃;	83.6%
With hydrogenchloride In water

: 140947-23-5
diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

: 74103-06-3
Ketorolac

Conditions

Conditions	Yield
Stage #1: diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate With sodium hydroxide In diethyl ether; water for 24h; Reflux; Stage #2: With hydrogenchloride In ethyl acetate at 70℃; for 4h;	80%
With sodium hydroxide In tetrahydrofuran for 9h; Time; Reflux; Green chemistry;	47.5%
With hydrogenchloride; sodium hydroxide 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h; Yield given. Multistep reaction;

: 66635-74-3
5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester

: 74103-06-3
Ketorolac

Conditions

Conditions	Yield
With potassium carbonate In methanol; water for 0.5h; Heating;	64%
With water In methanol; aq. phosphate buffer at 37℃; pH=8; Kinetics; pH-value;

: 84023-60-9
5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid

: 74103-06-3
Ketorolac

Conditions

Conditions	Yield
With hydrogen; magnesium oxide; palladium on activated charcoal In methanol; water under 760 Torr; for 2h; Ambient temperature; Yield given;

: 80965-05-5
2-[2-(2-Benzoyl-5-methanesulfonyl-pyrrol-1-yl)-ethyl]-malonic acid dimethyl ester

: 74103-06-3
Ketorolac

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 108061-03-6
ketorolac acid ethyl ester

: 74103-06-3
Ketorolac

Conditions

Conditions	Yield
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures;

: ketorolac acid <(N,N-dimethylamino)carbonyl>methyl ester

: 74103-06-3
Ketorolac

Conditions

Conditions	Yield
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures;

: 1885-14-9
phenyl chloroformate

: 74103-06-3
Ketorolac

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h 2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 3: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme

: 157071-48-2
(1H-pyrrol-2-yl)acetic acid isopropyl ester

: 74103-06-3
Ketorolac

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 96 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -70 deg C, 1 h 2: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h 3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 4: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme
Multi-step reaction with 4 steps 1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 40 h 2: 97 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -65 deg C to 0 deg C, ca. 0.5 h 3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 4: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme

Raw Materials

611-74-5

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Chemistry

IUPAC Name: 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Molecular Formula: C₁₅H₁₃NO₃
Molecular Weight: 255.27 g/mol
SMILES: n12c([C@@H](C(O)=O)CC2)ccc1C(c1ccccc1)=O
InChI: InChI=1/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
Classification Code: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Cyclooxygenase Inhibitors; Drug / Therapeutic Agent; Enzyme Inhibitors; Peripheral Nervous System Agents; Sensory System Agents
Product Categories: API's
Index of Refraction: 1.436
Molar Refractivity: 30.52 cm³
Molar Volume: 116.6 cm³
Polarizability: 12.1×10^-24 cm³
Surface Tension: 28.4 dyne/cm
Density: 1.398 g/cm³
Flash Point: 89.1 °C
Enthalpy of Vaporization: 46.02 kJ/mol
Boiling Point: 223.7 °C at 760 mmHg
Melting Point: 160-161 °C
Vapour Pressure of Ketorolac (CAS NO.74103-06-3): 0.0947 mmHg at 25 °C

Uses

Ketorolac (CAS NO.74103-06-3) is a non-steroidal anti-inflammatory drug, often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory. An ophthalmic (i.e., eye-drop) solution of Ketorolac is available and is used to treat eye pain and to relieve the itchiness and burning of seasonal allergies.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	200mg/kg (200mg/kg)		Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982.
mouse	LDLo	intraperitoneal	100mg/kg (100mg/kg)		Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982.

Safety Profile

RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup of Ketorolac (CAS NO.74103-06-3): II

Specification

Ketorolac (CAS NO.74103-06-3), its Synonyms are (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid ; (+-)-Ketorolac ; Ketorolacum ; 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)- .