CAS No.7421-40-1,Carbenoxolone disodium Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	7421-40-1
Name:	Carbenoxolone disodium

Formula:	C34H50 O7 . 2 Na
Molecular Weight:	614.80
Synonyms:	Olean-12-en-29-oicacid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, disodium salt, (3b,20b)- (9CI); Olean-12-en-30-oic acid, 3b-hydroxy-11-oxo-, hydrogensuccinate, disodium salt (7CI,8CI); 3-(Succinyloxy)glycyrrhetic acid disodiumsalt; Bioral; Carbenoxalone disodium salt; Carbenoxalone sodium; Carbenoxolonedisodium; Carbenoxolone disodium salt; Carbenoxolone sodium; Carbenoxolonesodium salt; Disodium glycyrrhetic acid hemisuccinate; Disodium glycyrrhetinylsuccinate; Duogastrone; Glycyrrhetic acid hydrosuccinate disodium salt;Glycyrrhetinic acid hydrogen succinate disodium salt; Glycyrrhetinic acidsuccinate disodium salt; Neogel; Pyrogastrone; Sanodin; Sodium carbenoxolone;Ulcus-Tablinen
EINECS:	231-044-0
Melting Point:	>275°C (dec.)
Boiling Point:	687.4oC at 760 mmHg
Flash Point:	211.6oC
Solubility:	Soluble in water to 100 mM.
Hazard Symbols:	Xn,Xi
Risk Codes:	22-36
Safety:	Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: blood pressure increase, change in blood potassium levels. Experimental reproductive effects. An anti-inflammatory agent used to treat gastric ulcers. When heated to decomposition it emits toxic fumes of Na₂O.
PSA:	123.63000
LogP:	4.15890

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Chemistry

Details of CARBENOXALONE, DISODIUM SALT (7421-40-1).
Molecular Formula:C₃₄H₄₈O₇^.2Na
Molecular Weight:614.80
Properties:Derived from licorice root. Medicinal uses.
Synonyms:(3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OIC ACID 3-HEMISUCCINATE) DISODIUM SALT;CARBENOXOLONE DISODIUM SALT;CARBENOXOLONE SODIUM;18-beta-glycyrrhetinicacidhydrogensuccinate,disodiumsalt;20-beta)-3-bet;3-beta-hydroxy-11-oxoolean-12-en-30-oicacidhydrogensuccinate,disodiumsal;3-o-(beta-carboxypropionyl)-11-oxo-18-beta-olean-12-en-30-oicacid,disodium;disodiumglycyrrhetinylsuccina
Structure:

Toxicity Data With Reference

1.	orl-hmn TDLo:120 mg/kg/6 W:CVS,MET	CMAJAX Canadian Medical Association Journal. 117 (1977),1155.
2.	orl-rat LD50:2450 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 11 (1976),263.
3.	ipr-rat LD50:112 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 10 (1979),710.
4.	scu-rat LD50:1515 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 10 (1979),710.
5.	ipr-mus LD50:120 mg/kg	21NDAB Symposium on Carbenoxolone Sodium Robson, J.M., andF.M. Sullivan, eds.,London, UK.: Butterworth,1968,6.
6.	ivn-mus LD50:198 mg/kg	21NDAB Symposium on Carbenoxolone Sodium Robson, J.M., andF.M. Sullivan, eds.,London, UK.: Butterworth,1968,6.
7.	orl-dog LD50:3900 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 10 (1979),710.
8.	ipr-dog LD50:371 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 10 (1979),710.
9.	scu-dog LD50:1060 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 11 (1976),263.
10.	ivn-dog LD50:371 mg/kg	OYYAA2 O CARBENOXALONE, DISODIUM SALT (7421-40-1) has toxicity. Organism Test Type Route Reported Dose (Normalized Dose) Effect Source dog LD50 intraperitoneal 371mg/kg (371mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 710, 1979. dog LD50 intravenous 371mg/kg (371mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 263, 1976. dog LD50 oral 3900mg/kg (3900mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 710, 1979. dog LD50 subcutaneous 1060mg/kg (1060mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 263, 1976. human TDLo oral 120mg/kg/6W (120mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION Canadian Medical Association Journal. Vol. 117, Pg. 1155, 1977. Link to PubMed mouse LD50 intraperitoneal 120mg/kg (120mg/kg) "Symposium on Carbenoxolone Sodium," Robson, J.M., and F.M. Sullivan, eds., London, Butterworth, 1968Vol. -, Pg. 6, 1968. mouse LD50 intravenous 198mg/kg (198mg/kg) "Symposium on Carbenoxolone Sodium," Robson, J.M., and F.M. Sullivan, eds., London, Butterworth, 1968Vol. -, Pg. 6, 1968. rabbit LD50 oral 2gm/kg (2000mg/kg) "Symposium on Carbenoxolone Sodium," Robson, J.M., and F.M. Sullivan, eds., London, Butterworth, 1968Vol. -, Pg. 6, 1968. rat LD50 intraperitoneal 92mg/kg (92mg/kg) Farmaco. Vol. 49, Pg. 281, 1994. Link to PubMed rat LD50 oral 2450mg/kg (2450mg/kg) CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SKIN AND APPENDAGES (SKIN): HAIR: OTHER Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 263, 1976. rat LD50 subcutaneous 1515mg/kg (1515mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 710, 1979.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: blood pressure increase, change in blood potassium levels. Experimental reproductive effects. An anti-inflammatory agent used to treat gastric ulcers. When heated to decomposition CARBENOXALONE, DISODIUM SALT (7421-40-1) emits toxic fumes of Na₂O.