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| CAS No.: | 74381-53-6 |
|---|---|
| Name: | Leuprorelin acetate |
| Molecular Structure: | |
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| Formula: | C59H84N16O12.C2H4O2 |
| Molecular Weight: | 1269.47 |
| Synonyms: | (D-Leu(sup 6),des-gly-NH2(sup 10),pro-ethylamide(sup 9))-LHRH;Lupron;Leuprolide acetate (USAN);Abbott 43818;Lupron Depot;TAP-144-SR;Leuprorelin acetate (JAN);Lupron PED;Leuprin;acetic acid; N-[(1S)-1-[[(1S)-1-[[1-[[(1S)-1-[[(1R)-1-[[(1S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxo-pentan-2-yl]carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]carbamoyl]-2-(4-hydroxyphenyl)ethyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl]-2-(3H-imidazol-4-yl)ethyl]-5-oxo-pyrrolidine-2-carboxamide;Procrin;A-43818;Leuproreline [INN-French];Eligard;Leuplin depot;TAP 144;Leuprorelinum [INN-Latin];Depo-Lupron;Viadur;Lucrin;TAP-144;Uno-Enantone;Procren Depot;Leuprorelina [INN-Spanish];Leuprolide acetate [USAN];(D-Leu(sup 6),des-gly-NH2(sup 10),pro-ethylamide(sup 9))-gonadotropin-releasing hormone; |
| EINECS: | 686-285-8 |
| Melting Point: | 150-155oC |
| Boiling Point: | 1720.5oC at 760 mmHg |
| Flash Point: | 994.3oC |
| Appearance: | fluffy solid |
| Safety: | 22-24/25 |
| PSA: | 466.34000 |
| LogP: | 3.44730 |
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- 74381-53-6
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate
| Conditions | Yield |
|---|---|
| With methanesulfonic acid; methyl-phenyl-thioether; ethane-1,2-dithiol for 1h; Ambient temperature; | 38.6% |
- 75-75-2
methanesulfonic acid
- 74381-53-6
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate
| Conditions | Yield |
|---|---|
| In water |
- 74381-53-6
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water |
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Chemistry
Chemical Name: Leuprorelin acetate
IUPAC NAME: N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CAS No.: 74381-53-6
Molecular Formula: C59H84N16O12
Molecular Weight: 1209.4 g/mol
Storage temp.: -20°C
Following is the structure of Leutenizing hormone-releasing factor (pig), 6-d-leucine-9-(n-ethyl-l-prolinamide)-10-deglycinamide-, monoacetate (salt) (74381-53-6):
Product Categories about Leuprorelin acetate are Organics ; Bases & Related Reagents ; Heterocycles ; Intermediates & Fine Chemicals ; Nucleotides ; Pharmaceuticals ; Gonadotropin-releasing hormone (GnRH)
The chemical synonymous of Leutenizing hormone-releasing factor (pig), 6-d-leucine-9-(n-ethyl-l-prolinamide)-10-deglycinamide-, monoacetate (salt) (74381-53-6) are Leutenizinghormone-releasingfactor(pig),6-d-leucine-9-(n-ethyl-l-prolinamid ; Lupron ; Tap-144 ; Tap-144-Sr ; Des-Gly10,[P-Leu6]-Lh-Rh ethylamide ; [Des-Gly10, D-Leu6, Pro-Nhet9]-Lh-Rh (Human) ; (Des-Gly10,D-Leu6,Pro-Nhet9)-Luteinizing hormone-releasing factor ; (Des-gly10,d-leu6,pro-nhet9)-luteinizing hormone-releasing hormone
Uses
Leutenizing hormone-releasing factor (pig), 6-d-leucine-9-(n-ethyl-l-prolinamide)-10-deglycinamide-, monoacetate (salt) (74381-53-6) is mainly used as synthetic nonapeptide agonist analog of LH-RH. and used for antineoplastic (hormonal).
Toxicity Data With Reference
| 1. | orl-rat LD50:>5 g/kg | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 18 (Suppl 3)(1990),S569. | ||
| 2. | ipr-rat LD50:>5 g/kg | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 18 (Suppl 3)(1990),S569. | ||
| 3. | scu-rat LD50:>5 g/kg | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 18 (Suppl 3)(1990),S569. | ||
| 4. | ivn-rat LD50:29,900 µg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 25 (1994),815. | ||
| 5. | ims-rat LD50:>2 g/kg | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 18 (Suppl 3)(1990),S569. | ||
| 6. | orl-mus LD50:>5 g/kg | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 18 (Suppl 3)(1990),S569. | ||
| 7. | ipr-mus LD50:>5 g/kg | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 18 (Suppl 3)(1990),S569. | ||
| 8. | scu-mus LD50:>5 g/kg | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 18 (Suppl 3)(1990),S569. | ||
| 9. | ivn-mus LD50:137 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 25 (1994),815. | ||
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Safety Profile
A poison by intravenous route. Moderately toxic by imps route. Low toxicity by ingestion, subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx.
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