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CAS No.: | 74572-04-6 |
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Name: | (R)-3-Methylmorpholine |
Article Data: | 10 |
Molecular Structure: | |
Formula: | C5H11NO |
Molecular Weight: | 101.148 |
Synonyms: | Morpholine,3-methyl-, (R)-;(3R)-3-Methylmorpholine;(R)-3-Methylmorpholine; |
Density: | 0.891 g/cm3 |
Boiling Point: | 137.1 °C at 760 mmHg |
Flash Point: | 41.3 °C |
PSA: | 21.26000 |
LogP: | 0.32350 |
(R)-4-(4-methoxybenzyl)-3-methylmorpholine
(3R)-3-methylmorpholine
Conditions | Yield |
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With palladium on activated charcoal; hydrogen In methanol at 50℃; under 9500.64 Torr; for 18h; | 83% |
(5R)-5-methylmorpholin-3-one
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 16h; | 75% |
Stage #1: (5R)-5-methylmorpholin-3-one With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 15.5h; Heating / reflux; Stage #2: With hydrogenchloride; ethanol In tetrahydrofuran |
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Stage #1: (R)-2-(2-hydroxyethylamino)propan-1-ol With sulfuric acid at 140℃; for 14h; Stage #2: With sodium hydroxide In water at 0℃; | 65% |
2-(prop-2-yn-1-yloxy)ethan-1-amine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Stage #1: 2-(prop-2-yn-1-yloxy)ethan-1-amine With C42H58N4O2Ti In toluene at 110℃; for 14h; Inert atmosphere; Schlenk technique; Stage #2: With formic acid; [{(1S,2S-N-p-toluenesulfonyl-1,2-diphenylethanediamine)}(η6-p-cymene)RuCl]; triethylamine In N,N-dimethyl-formamide; toluene at 20℃; for 14h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 65% |
Multi-step reaction with 2 steps 1: bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) / toluene / 14 h / 110 °C / Inert atmosphere; Glovebox; Schlenk technique; Sealed tube 2: formic acid; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); triethylamine / N,N-dimethyl-formamide / 23 °C / Inert atmosphere; Schlenk technique View Scheme | |
Multi-step reaction with 2 steps 1: bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) / toluene / 14 h / 110 °C / Inert atmosphere; Glovebox; Schlenk technique; Sealed tube 2: formic acid; silver trifluoromethanesulfonate; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); triethylamine / N,N-dimethyl-formamide / 16 h / 23 °C / Inert atmosphere; Schlenk technique View Scheme |
(3R)-3-methyl-4-(phenylmethyl)morpholine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal at 80℃; under 45600 - 60800 Torr; for 2h; | |
With hydrogen; palladium 10% on activated carbon In ethanol under 2585.81 Torr; | |
With hydrogen; hydrogenchloride; palladium 10% on activated carbon In 1,4-dioxane; ethyl acetate under 2068.65 Torr; for 18h; |
(R)-2-[Benzyl-(2-hydroxy-ethyl)-amino]-propan-1-ol
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70percent H2SO4 / 15 h / 140 °C 2: H2 / 10percent Pd/C / 2 h / 80 °C / 45600 - 60800 Torr View Scheme |
(R)-2-bromo-N-(1-hydroxypropan-2-yl)-N-(4-methoxybenzyl)acetamide
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran / 25 °C / Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux 3: palladium on activated charcoal; hydrogen / methanol / 18 h / 50 °C / 9500.64 Torr View Scheme |
(R)-4-(4-methoxybenzyl)-5-methylmorpholin-3-one
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux 2: palladium on activated charcoal; hydrogen / methanol / 18 h / 50 °C / 9500.64 Torr View Scheme |
Conditions | Yield |
---|---|
In dichloromethane at 23℃; Inert atmosphere; |
2-chloro-N-(2-hydroxy-1-methyl-ethyl)-acetamide
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 1 h / 0 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C View Scheme |
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The cas register number of (R)-3-Methylmorpholine is 74572-04-6. It also can be called as Morpholine,3-methyl-, (3R)- and the Systematic name about this chemical is Morpholine,3-methyl-, (3R)-.
Physical properties about (R)-3-Methylmorpholine are: (1)ACD/LogP: -0.59; (2)ACD/LogD (pH 5.5): -3.55; (3)ACD/LogD (pH 7.4): -2.22; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)Polar Surface Area: 12.47Å2; (11)Index of Refraction: 1.409; (12)Molar Refractivity: 28.1 cm3; (13)Molar Volume: 113.5 cm3; (14)Polarizability: 11.14x10-24cm3; (15)Surface Tension: 26.2 dyne/cm; (16)Enthalpy of Vaporization: 37.45 kJ/mol; (17)Vapour Pressure: 7.14 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O1C[C@H](NCC1)C
(2)InChI: InChI=1/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3/t5-/m1/s1
(3)InChIKey: SFWWGMKXCYLZEG-RXMQYKEDBJ
(4)Std. InChI: InChI=1S/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3/t5-/m1/s1
(5)Std. InChIKey: SFWWGMKXCYLZEG-RXMQYKEDSA-N