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CAS No.: | 74772-77-3 |
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Name: | CIGLITAZONE |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C18H23NO3S |
Molecular Weight: | 333.452 |
Synonyms: | ADD 3878;Ciglitazone;U 63287; |
Density: | 1.189 g/cm3 |
Melting Point: | 130-131 °C |
Boiling Point: | 504.5 °C at 760 mmHg |
Flash Point: | 258.9 °C |
Appearance: | white cyrstalline solid |
PSA: | 80.70000 |
LogP: | 4.25870 |
The 2,4-Thiazolidinedione,5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-, with the CAS registry number 74772-77-3, is also known as Ciglitizone. It belongs to the product categories of Active Pharmaceutical Ingredients; Metal Isotopes; Sulfur & Selenium Compounds; API's; Intracellular receptor. This chemical's molecular formula is C18H23NO3S and molecular weight is 333.44512. Its IUPAC name is called 5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione. This chemical's classification code are Antidiabetic; Drug / Therapeutic Agent; Hypoglycemic agents; Reproductive Effect. The product should be sealed and stored in cool and dry place. It is white cyrstalline solid. This chemical will display antihyperglycemic activity in genetically obese mice. It is a selective PPARg agonist.
Physical properties of 2,4-Thiazolidinedione,5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-: (1)ACD/LogP: 4.69; (2)ACD/LogD (pH 5.5): 4.63; (3)ACD/LogD (pH 7.4): 3.61; (4)#H bond acceptors: 4; (5)#H bond donors: 1; (6)#Freely Rotating Bonds: 5; (7)Index of Refraction: 1.568; (8)Molar Refractivity: 91.74 cm3; (9)Molar Volume: 280.4 cm3; (10)Surface Tension: 45.7 dyne/cm; (11)Density: 1.189 g/cm3; (12)Flash Point: 258.7 °C; (13)Enthalpy of Vaporization: 77.35 kJ/mol; (14)Boiling Point: 504.1 °C at 760 mmHg; (15)Vapour Pressure: 2.73E-10 mmHg at 25°C.
Preparation: this chemical can be prepared by 2-imino-5-[4-(1-methylcyclohexylmethoxy)benzyl]thiazolidin-4-one. This reaction will need reagent 2N HCl and solvent 2-methoxy-ethanol. The reaction time is 6 hours. The yield is about 88.3%.
Uses of 2,4-Thiazolidinedione,5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-: it can be used to produce (+/-)-3-methyl-5-[4-(1-methylcyclohexylmethoxy)benzyl]-2,4-thiazolidinedione. This reaction will need solvent diethyl ether with reaction time of 30 min. The yield is about 86.5%.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
(2)InChI: InChI=1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)
(3)InChIKey: YZFWTZACSRHJQD-UHFFFAOYSA-N