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74847-35-1

Basic Information
CAS No.: 74847-35-1
Name: Pyronaridine
Article Data: 6
Molecular Structure:
Molecular Structure of 74847-35-1 (Pyronaridine)
Formula: C29H32 Cl N5 O2
Molecular Weight: 518.058
Synonyms: Benzo[b]-1,5-naphthyridine,phenol deriv.; Malaridine; Pyronaridine
EINECS: 1533716-785-6
Density: 1.37g/cm3
Boiling Point: 657.2oC at 760 mmHg
Flash Point: 351.3oC
Solubility: Toxicity data
(The meaning of any toxicological abbreviations w">

Stability

    Incompatible with strong oxidizing agents.

Toxicology

    No toxicological data available.

    Toxicity data
    (The meaning of any toxicological abbreviations w

Appearance: solid
Safety: Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl and NOx. An antimalarial drug.
PSA: 76.72000
LogP: 5.44880
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  • Pyronaridine

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Chemistry

IUPAC Name: 4-[(7-Chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one
The MF of Pyronaridine (CAS NO.74847-35-1) is C29H32ClN5O2.

                
The MW of Pyronaridine (CAS NO.74847-35-1) is 518.0497.
Synonyms of Pyronaridine (CAS NO.74847-35-1): 4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol ; Phenol, 4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)-
Stability: Incompatible with strong oxidizing agents
Index of Refraction: 1.719 
Apperance: solid
Density: 1.356 g/ml 
Flash Point: 329.6 °C
Boiling Point: 621.3 °C

Uses

   Pyronaridine (CAS NO.74847-35-1) is an antimalarial drug. It was first synthesized in 1970 and has been in clinical use in China since the 1980s.

Toxicity Data With Reference

1.    

mmo-sat 100 µg/plate

    CYLPDN    Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. 3 (1982),51.
2.    

orl-mus LD50:1100 mg/kg

    YHHPAL    Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. 17 (1982),401.

Safety Profile

Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl and NOx. An antimalarial drug.