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Basic Information

Molecular Structure:
CAS No.:	76-25-5
Name:	Triamcinolone acetonide
Article Data:	22

Formula:	C₂₄H₃₁FO₆
Molecular Weight:	434.505
Synonyms:	Aristocort A;Azmacort;Berlicort;Extracort;Kenacort 80;Kenacort A 40;Kenalog;Kenalog 10;Kenalog 40;Ledercort Cream;Lichtena;Nasacort;Respicort;Rineton;TAC 3;Tamceton;Tramacin;Tri-Nasal;Triacet;Triamcinolone 16,17-acetonide;Triamcort-Depot;Triamhexal;Trianopollon;Tricinolon;Vetalog;Vetazine;Volon A;Volonimat;Triamcinalone acetonide;Pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11b,16a)-;9-Fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide;9a-Fluoro-11b,21-dihydroxy-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione;9a-Fluoro-16a-hydroxyprednisolone 16a,17a-acetonide;Adcortyl A;Aristocort acetonide;
EINECS:	200-948-7
Density:	1.33 g/cm³
Melting Point:	274-278°C (dec.)
Boiling Point:	576.9 °C at 760 mmHg
Flash Point:	302.7 °C
Solubility:	Soluble in DMSO or ethanol. Slightly soluble in water.
Appearance:	White solid
Hazard Symbols:
Risk Codes:	61
Safety:	53-45
PSA:	93.06000
LogP:	2.41880

Synthetic route

: 124-94-7
triamcinolone

: 67-64-1
acetone

: 76-25-5
triamcinolone acetonide

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate at -10 - 0℃;	93%
With hydrogenchloride for 1h; Heating;	52%
With methanesulfonic acid at 50℃; for 2h; Temperature;

: 64089-14-1
11β-trimethylsiloxy-21-acetoxy-16α,17α-isopropylidenedioxy-9α-fluoro-pregna-1,4-diene-3,20-dione

A triamcinolone acetonide, 21-acetate: triamcinolone acetonide, 21-acetate

B: 76-25-5
triamcinolone acetonide

Conditions

Conditions	Yield
With sodium carbonate In aqueous hydrofluoric acid	A 80% B n/a

: C24H30O6

: 76-25-5
triamcinolone acetonide

Conditions

Conditions	Yield
With hydrogen fluoride In chloroform at -40℃;	76%

: 1524-86-3
16α-17-[(1-methylethylidene)bis(oxy)]-11β,21-dihydroxy-9-fluoro-4-ene-pregna-3,20-dione

: 76-25-5
triamcinolone acetonide

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In benzene for 70h; Heating;	40%

: 124-94-7
triamcinolone

: 76-25-5
triamcinolone acetonide

Conditions

Conditions	Yield
With perchloric acid; acetone
With hydrogenchloride; acetone

: 13951-70-7
desonide

: 76-25-5
triamcinolone acetonide

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: pyridine 2: SOCl2; pyridine 3: aqueous HClO4; dioxane 4: potassium acetate; ethanol 5: CHCl3; HF 6: methanol.KOH 7: acetone; hydrochloric acid View Scheme

: 23460-76-6
21-acetoxy-pregna-4,9(11),16-triene-3,20-dinone

: 76-25-5
triamcinolone acetonide

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: KMnO4 2: pyridine 3: aqueous HClO4; dioxane 4: potassium acetate; ethanol / Behandeln einer Loesung des Reaktionsprodukts in Pyridin mit Acetanhydrid 5: CHCl3; HF 6: mit Hilfe von Nocardia corallina 7: methanol.KOH 8: acetone; hydrochloric acid View Scheme

: 74220-43-2
21-Acetoxy-16α,17α-dihydroxy-4,9(11)-pregnadien-3,20-dion

: 76-25-5
triamcinolone acetonide

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: pyridine 2: aqueous HClO4; dioxane 3: potassium acetate; ethanol / Behandeln einer Loesung des Reaktionsprodukts in Pyridin mit Acetanhydrid 4: CHCl3; HF 5: mit Hilfe von Nocardia corallina 6: methanol.KOH 7: acetone; hydrochloric acid View Scheme

: 95943-95-6
16α,21-diacetoxy-17-hydroxy-pregna-1,4,9(11)-triene-3,20-dione

: 76-25-5
triamcinolone acetonide

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: aqueous HClO4; dioxane 2: potassium acetate; ethanol 3: CHCl3; HF 4: methanol.KOH 5: acetone; hydrochloric acid View Scheme

: 98422-55-0
16α,21-diacetoxyprednisolone

: 76-25-5
triamcinolone acetonide

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: SOCl2; pyridine 2: aqueous HClO4; dioxane 3: potassium acetate; ethanol 4: CHCl3; HF 5: methanol.KOH 6: acetone; hydrochloric acid View Scheme

Raw Materials

67-78-7

1524-86-3

23460-76-6

74220-43-2

67-64-1

124-94-7

13951-70-7

Downstream Products

3870-07-3

110-99-6

Total:237 Page 1 of 7 1 2 3 4 5 6 …7 Next>>

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

1. Introduction of Triamcinolone acetonide

Triamcinolone acetonide, with the Systematic Name of (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-Fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, is one kind of white solid. For being incompatible with strong oxidizing agents, it belongs to the Product Categories which include Biochemistry; Steroids; Steroids (Others); Intermediates & Fine Chemicals; Pharmaceuticals. Besides, its Classification Code are including Adrenal Cortex Hormones; Anti-Inflammatory Agents; Drug / Therapeutic Agent; Glucocorticoid; Glucocorticoids; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Human Data; Immunologic Factors; Immunosuppressive agents; Mutation data; Reproductive Effect.

2. Properties of Triamcinolone acetonide

Triamcinolone acetonide has the below properties: (1)Molar Refractivity: 109.41 cm³; (2)Molar Volume: 324.8 cm³; (3)Surface Tension: 54.5 dyne/cm; (4)Density: 1.33 g/cm³; (5)Flash Point: 302.7 °C; (6)Enthalpy of Vaporization: 99.19 kJ/mol; (7)Boiling Point: 576.9 °C at 760 mmHg; (8)Vapour Pressure: 1.04E-15 mmHg at 25 °C; (9)Appearance: White Solid; (10)Melting Point: 274-278 °C (dec.).

3. Toxicity of Triamcinolone acetonide

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	intramuscular	571ug/kg (0.571mg/kg)	VASCULAR: SHOCK SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Annals of Pharmacotherpy. Vol. 28, Pg. 1310, 1994.
mouse	LD50	intraperitoneal	105mg/kg (105mg/kg)		Drugs in Japan Vol. 6, Pg. 516, 1982.
mouse	LD50	oral	5gm/kg (5000mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
mouse	LD50	subcutaneous	132mg/kg (132mg/kg)		Drugs in Japan Vol. 6, Pg. 516, 1982.
rat	LD50	subcutaneous	13100ug/kg (13.1mg/kg)		Drugs of the Future. Vol. 6, Pg. 44, 1981.
women	TDLo	parenteral	4mg/kg (4mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Netherlands Journal of Medicine. Vol. 56, Pg. 12, 2000.

4. Safety Information of Triamcinolone acetonide

Poison by subcutaneous and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and toxic fumes of F⁻.
Hazard Codes: Toxic T
Risk Statements: 61
R61:May cause harm to the unborn child.
Safety Statements: 53-45
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: TU3920000

5. Use and Preparation of Triamcinolone acetonide

Aristocort acetonide can be used as adrenal cortical hormone medicines and also used in neurodermatitis, eczema, psoriasis, joint pain, bronchial asthma and other illnesses.

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