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76-25-5

Basic Information
CAS No.: 76-25-5
Name: Triamcinolone acetonide
Molecular Structure:
Molecular Structure of 76-25-5 (Triamcinolone acetonide)
Formula: C24H31FO6
Molecular Weight: 434.55
Synonyms: Aristocort A;Azmacort;Berlicort;Extracort;Kenacort 80;Kenacort A 40;Kenalog;Kenalog 10;Kenalog 40;Ledercort Cream;Lichtena;Nasacort;Respicort;Rineton;TAC 3;Tamceton;Tramacin;Tri-Nasal;Triacet;Triamcinolone 16,17-acetonide;Triamcort-Depot;Triamhexal;Trianopollon;Tricinolon;Vetalog;Vetazine;Volon A;Volonimat;Triamcinalone acetonide;Pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11b,16a)-;9-Fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide;9a-Fluoro-11b,21-dihydroxy-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione;9a-Fluoro-16a-hydroxyprednisolone 16a,17a-acetonide;Adcortyl A;Aristocort acetonide;
EINECS: 200-948-7
Density: 1.33 g/cm3
Melting Point: 274-278°C (dec.)
Boiling Point: 576.9 °C at 760 mmHg
Flash Point: 302.7 °C
Solubility: Soluble in DMSO or ethanol. Slightly soluble in water.
Appearance: White solid
Hazard Symbols:
Risk Codes: 61
Safety: 53-45
Transport Information:
PSA: 93.06000
LogP: 2.41880
Downstream Products
110-99-6
3870-07-3
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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

1. Introduction of Triamcinolone acetonide

Triamcinolone acetonide, with the Systematic Name of (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-Fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, is one kind of white solid. For being incompatible with strong oxidizing agents, it belongs to the Product Categories which include Biochemistry; Steroids; Steroids (Others); Intermediates & Fine Chemicals; Pharmaceuticals. Besides, its Classification Code are including Adrenal Cortex Hormones; Anti-Inflammatory Agents; Drug / Therapeutic Agent; Glucocorticoid; Glucocorticoids; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Human Data; Immunologic Factors; Immunosuppressive agents; Mutation data; Reproductive Effect.

2. Properties of Triamcinolone acetonide

Triamcinolone acetonide has the below properties: (1)Molar Refractivity: 109.41 cm3; (2)Molar Volume: 324.8 cm3; (3)Surface Tension: 54.5 dyne/cm; (4)Density: 1.33 g/cm3; (5)Flash Point: 302.7 °C; (6)Enthalpy of Vaporization: 99.19 kJ/mol; (7)Boiling Point: 576.9 °C at 760 mmHg; (8)Vapour Pressure: 1.04E-15 mmHg at 25 °C; (9)Appearance: White Solid; (10)Melting Point: 274-278 °C (dec.).

3. Toxicity of Triamcinolone acetonide

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intramuscular 571ug/kg (0.571mg/kg) VASCULAR: SHOCK

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Annals of Pharmacotherpy. Vol. 28, Pg. 1310, 1994.
mouse LD50 intraperitoneal 105mg/kg (105mg/kg)   Drugs in Japan Vol. 6, Pg. 516, 1982.
mouse LD50 oral 5gm/kg (5000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
mouse LD50 subcutaneous 132mg/kg (132mg/kg)   Drugs in Japan Vol. 6, Pg. 516, 1982.
rat LD50 subcutaneous 13100ug/kg (13.1mg/kg)   Drugs of the Future. Vol. 6, Pg. 44, 1981.
women TDLo parenteral 4mg/kg (4mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
Netherlands Journal of Medicine. Vol. 56, Pg. 12, 2000.

4. Safety Information of Triamcinolone acetonide

Poison by subcutaneous and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and toxic fumes of F.
Hazard Codes: ToxicT
Risk Statements: 61 
R61:May cause harm to the unborn child.
Safety Statements: 53-45 
S53:Avoid exposure - obtain special instructions before use. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: TU3920000

5. Use and Preparation of Triamcinolone acetonide

Aristocort acetonide can be used as adrenal cortical hormone medicines and also used in neurodermatitis, eczema, psoriasis, joint pain, bronchial asthma and other illnesses.