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| CAS No.: | 7646-69-7 |
|---|---|
| Name: | Sodium hydride |
| Article Data: | 112 |
| Molecular Structure: | |
|
|
|
| Formula: | HNa |
| Molecular Weight: | 23.9977 |
| Synonyms: | NSC605606;NSC 609472;Sodium monohydride; |
| EINECS: | 231-587-3 |
| Density: | 1.2 g/cm3 |
| Melting Point: | 800 °C (dec.)(lit.) |
| Flash Point: | 185 °C |
| Solubility: | reacts with water |
| Appearance: | Grey solid |
| Hazard Symbols: |
 F
|
| Risk Codes: | 15-36 |
| Safety: | 26-43-7/8-43A-24/25-7 |
| Transport Information: | UN 1427 4.3/PG 1 |
| PSA: | 0.00000 |
| LogP: | 0.00000 |
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| Conditions | Yield |
|---|---|
| In tetrahydrofuran heating under increasing H2-pressure (from about 7 to 35atm) to 250-350°C;; | 98% |
| In further solvent(s) heating in mineral oil or in another hydrocarbon (high b.p.) under increasing H2-pressure (from about 7 to 35atm) to 250-350°C;; | 98% |
| In paraffin heating under increasing H2-pressure (from about 7 to 35atm) to 250-350°C;; | 98% |
| Conditions | Yield |
|---|---|
| With naphthalene In 1,2-dimethoxyethane byproducts: H2, SiH2; stirring a mixture of sodium, naphthalene and DME for 1 h, addn. of silane under argon; filtn., washing (ether in a vac. at 288 K for 14 h), elem. anal.; | 97.8% |
| Conditions | Yield |
|---|---|
| In neat (no solvent) heating the powdered carbide in an autoclave (H2 pressure: 500atm)in a H2-stream to 650°C;; 72% NaH;; | 86% |
| In neat (no solvent) heating the powdered carbide in an autoclave (H2 pressure: 500atm)in a H2-stream to 650°C;; 72% NaH;; | 86% |
- 7440-21-3
monosilane
A
- 139508-55-7
sodium disilanyl
B
- 139508-56-8
2-sodium trisilanyl
C
- 139508-57-9
2-sodium isotetrasilanyl
D
- 7646-69-7
sodium hydride
| Conditions | Yield |
|---|---|
| With sodium In diethylene glycol Under N2, filling of SiH4 in an evacuated flask with a freshly prepd. Na dispersion at -30 or 25°C under magnetic stirring. End of react. is reached after 3 days.; Concg. in vac. under stirring, filtn. (NaH), addn. of benzylchloride, GC.; | A 17.7% B 1.6% C 0% D 2.1% E 78.6% |
| With Na on activated charcoal In 1,2-dimethoxyethane Under N2, filling of SiH4 in an evacuated flask with a freshly prepd. Na dispersion at -30 or 25°C under magnetic stirring. End of react. is reached after 3 days.; Concg. in vac. under stirring, filtn. (NaH), addn. of benzylchloride, GC.; | A 30.4% B 4.6% C <1 D 0% E 65% |
| With sodium In 1,2-dimethoxyethane Under N2, filling of SiH4 in an evacuated flask with a freshly prepd. Na dispersion at -30 or 25°C under magnetic stirring. End of react. is reached after 3 days.; Concg. in vac. under stirring, filtn. (NaH), addn. of benzylchloride, GC.; | A 25.4-28.6 B 1.2-3.5 C <1 D 0-25.1 E 48.3-68.2 |
| Conditions | Yield |
|---|---|
| In neat (no solvent) byproducts: Al; dehydrogenation: 160°C, against 0.1 MPa for 3 h; detd. of H2 with Sieverts type volumetric apparatus; XRD; | A 4% B n/a |
| Conditions | Yield |
|---|---|
| titanium(III) chloride at 200 - 250℃; under 760.051 Torr; Product distribution / selectivity; Neat (no solvent); Balled milled; | |
| In neat (no solvent, solid phase) decompd. at heating; |
| Conditions | Yield |
|---|---|
| In neat (no solvent) byproducts: NH3; at about 120°C;; |
| Conditions | Yield |
|---|---|
| In neat (no solvent) reaction of H2 with NaN3 at 300°C (under no circumstances 375°C); using of activated H2 is advantageous;; | |
| In neat (no solvent) reaction of H2 with NaN3 at 300°C (under no circumstances 375°C); using of activated H2 is advantageous;; |
| Conditions | Yield |
|---|---|
| In neat (no solvent) heated in a H2-stream;; | |
| In neat (no solvent) heated in a H2-stream;; | |
| In neat (no solvent) byproducts: NH3; begin of react. at about 250°C;; |
| Conditions | Yield |
|---|---|
| In neat (no solvent) with over-heated H2O-vapor between 250 and 400°C;; | |
| In neat (no solvent) with over-heated H2O-vapor between 250 and 400°C;; |
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Chemistry
IUPAC Name: Sodium
Synonyms of Sodium hydride (CAS NO.7646-69-7): EINECS 231-587-3 ; HSDB 745 ; NAH 80 ; Sodium hydride (NaH) ; Sodium monohydride ; Sodium hydride [UN1427] [Dangerous when wet] ; UN1427
CAS NO: 7646-69-7
Molecular Formula: HNa
Molecular Weight: 24
Molecular Structure:
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Melting Point: 800 °C
ProductCategories: Inorganics ; Classes of Metal Compounds ; Na (Sodium) Compounds (excluding simple sodium salts) ; Reduction ; Synthetic Organic Chemistry ; Typical Metal Compounds ; Materials for Hydrogen Storage ; Metal Hydrides ; Metal HydridesAlternative Energy ; Synthetic Reagents
Density: 1.2 g/cm3
Flash Point: 185°C
Storage temp.: Store at RT.
Form powder: (moistened with oil)
Water Solubility: REACTS
Sensitive: Air & Moisture Sensitive
Merck: 14,8625
Uses
Sodium hydride (CAS NO.7646-69-7) is primarily used as a strong base in the organic synthesis.It is a base of wide scope and utility in the organic chemistry. It has the main uses as follows:
1.capable of deprotonating a range of even weak Bronsted acids to give the corresponding sodium derivatives. The resulting sodium derivatives can be alkylated.
2.Sodium hydride is most notably employed to deprotonate carbon acids such as 1,3-dicarbonyls and analogues such as malonic esters.
3.It is widely used to promote condensation reactions of carbonyl compounds via the Dieckmann condensation, Stobbe condensation, Darzens condensation, and Claisen condensation.
4.Sodium hydride is also used to make sulfur ylides, which in turn are used to convert ketones into epoxides.Sodium hydride reduces certain main group compounds, but the analogous reactivity is unknown in the organic chemistry.
5.Because of its rapid and irreversible reaction with water, Sodium hydride can be used to dry some organic solvents.
Toxicity Data With Reference
| 1. | ipr-rat LD50:91 mg/kg | IJEBA6 Indian Journal of Experimental Biology. 5 (1967),96. | ||
| 2. | scu-rat LD50:279 mg/kg | IJEBA6 Indian Journal of Experimental Biology. 5 (1967),96. | ||
| 3. | ivn-rat LD50:105 mg/kg | IJEBA6 Indian Journal of Experimental Biology. 5 (1967),96. | ||
| 4. | ipr-mus LD50:83 mg/kg | IJEBA6 Indian Journal of Experimental Biology. 5 (1967),96. | ||
| 5. | scu-mus LD50:400 mg/kg | 85GDA2 CRC Handbook of Antibiotic Compounds, Volumes 1-9. 8 (1)(1982),331. | ||
| 6. | ivn-mus LD50:97 mg/kg | IJEBA6 Indian Journal of Experimental Biology. 5 (1967),96. |
Safety Profile
Hazard Codes of Sodium hydride (CAS NO.7646-69-7): 
F
Risk Statements: 15-36
R15: Contact with water liberates extremely flammable gases.
R36: Irritating to eyes.
Safety Statements: 26-43-7/8-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S43: In case of fire use ... (there follows the type of fire-fighting equipment to be used.)
S7: Keep container tightly closed.
S8: Keep container dry.
S24/25: Avoid contact with skin and eyes.
RIDADR: UN 1427 4.3/PG 1
WGK Germany: 3
RTECS: WB3910000
F: 10-21
HazardClass: 4.3
PackingGroup: I
Specification
Sodium hydride (CAS NO.7646-69-7) can ignite in air, especially upon contacting with water to release hydrogen.