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765-34-4

Basic Information
CAS No.: 765-34-4
Name: GLYCIDALDEHYDE
Article Data: 16
Molecular Structure:
Molecular Structure of 765-34-4 (GLYCIDALDEHYDE)
Formula: C3H4 O2
Molecular Weight: 72.0636
Synonyms: Glycidaldehyde(6CI,7CI,8CI); Oxiranecarboxaldehyde (9CI); 2,3-Epoxypropanal;Epihydrinaldehyde; Epoxypropanal; Formyloxirane; Glycidal; NSC 521506
Density: 1.417g/cm3
Melting Point: -62°C
Boiling Point: 112.5°C at 760 mmHg
Flash Point: 29.921°C
Appearance: white to light yellow crystal powde
Hazard Symbols: C,Xi
Risk Codes: R11
Safety: Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Moderately toxic by inhalation. Human systemic effects by inhalation: changes in central nervous system electrical activity, olfactory changes, and excitement. Mutation data reported. A human eye irritant. Powerful skin sensitizer and mucous membrane irritant. Flammable when exposed to heat, flame, or oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALDEHYDES.
PSA: 29.60000
LogP: -0.41590
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Chemistry

Glycidaldehyde is also named as 2,3-Epoxypropionaldehyde;2,3-epoxy-1-propanal;2,3-epoxypropanal;2,3-epoxy-propionaldehyd;epihydrinaldehyde;epihydrinealdehyde;formyloxiran,and so on.

Molecular Formula: C3H4O2
Molecular Weight: 72.06
EINECS: 212-143-8
Melting point: -61.8 °C
Boiling point: 112-113 °C
Density: 1.14(20 °C)

Uses

Glycidaldehyde is commonly used in cotton processing, leather tanning and  protein coagulation as the chemical intermediates and cross-linking agent.

Toxicity Data With Reference

1.   

eye-hmn 1 ppm/5M MOD

   AEHLAU    Archives of Environmental Health. 2 (1961),23.
2.   

mmo-esc 10 µg/plate

   ENMUDM    Environmental Mutagenesis. 6 (Suppl 2)(1984),1.
3.   

mma-esc 33,300 ng/plate

   ENMUDM    Environmental Mutagenesis. 6 (Suppl 2)(1984),1.
4.   

skn-rbt 100 mg/24H MOD

   85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,770.
5.   

scu-rat TDLo:13 g/kg/77W-I:CAR

   JNCIAM    Journal of the National Cancer Institute. 39 (1967),1213.
6.   

ihl-hmn TCLo:5 ppm:BRN,EYE,CNS

   34ZIAG    Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,289.
7.   

orl-rat LDLo:50 mg/kg

   AJHYA2    American Journal of Hygiene. 76 (1962),209.
8.   

ihl-rat LCLo:251 ppm/4H

   14CYAT    Industrial Hygiene and Toxicology. 2 (1963),1636.
9.   

ipr-mus LD50:200 mg/kg

   JJIND8    JNCI, Journal of the National Cancer Institute. 62 (1979),911.
10.   

skn-rbt LD50:249 mg/kg

   AEHLAU    Archives of Environmental Health

RTECS: MB3150000

Consensus Reports

IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 11 , 1976,p. 175.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Moderately toxic by inhalation. Human systemic effects by inhalation: changes in central nervous system electrical activity, olfactory changes, and excitement. Mutation data reported. A human eye irritant. Powerful skin sensitizer and mucous membrane irritant. Flammable when exposed to heat, flame, or oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes.

Risk Statements: 11
Safety Statements:  9-16-33
RIDADR:  2622
HazardClass:  3.1
PackingGroup:  II

Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid, Poison