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| CAS No.: | 77472-71-0 |
|---|---|
| Name: | 2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide |
| Molecular Structure: | |
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| Formula: | C12H15N3O2 |
| Molecular Weight: | 233.27 |
| Synonyms: | 2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide |
| EINECS: | 204-259-2 |
| Density: | 1.243±0.06 g/cm3(Predicted) |
| Melting Point: | 154-155 °C |
| Boiling Point: | 529.4±50.0 °C(Predicted) |
| PSA: | 75.43000 |
| LogP: | 1.02150 |

2-oxo-4-phenyl-1-pyrrolidineacetic acid, ethyl ester


2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

| Conditions | Yield |
|---|---|
| With hydrazine hydrate at 0 - 20℃; for 20h; | 78% |
| With hydrazine hydrate In ethanol for 8h; Heating; | 67% |

4-phenylpyrrolidin-2-one


2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 1.) NaH / 1.) dioxane, 90 deg C, 1 h, 2.) 125 deg C, 5 h 2: 67 percent / hydrazine hydrate / ethanol / 8 h / Heating View Scheme |

2-oxo-4-phenylpyrrolidine-3-carboxylic acid


2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 58 percent / 0.5 h / 190 °C 2: 1.) NaH / 1.) dioxane, 90 deg C, 1 h, 2.) 125 deg C, 5 h 3: 67 percent / hydrazine hydrate / ethanol / 8 h / Heating View Scheme |

3-methoxycarbonyl-4-phenyl-2-pyrrolidone


2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 89.6 percent / 10percent aq. KOH / 5 h / Heating 2: 58 percent / 0.5 h / 190 °C 3: 1.) NaH / 1.) dioxane, 90 deg C, 1 h, 2.) 125 deg C, 5 h 4: 67 percent / hydrazine hydrate / ethanol / 8 h / Heating View Scheme |

4-chlorobenzaldehyde


2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

| Conditions | Yield |
|---|---|
| In ethanol Reflux; | 89% |

2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide


acetone

| Conditions | Yield |
|---|---|
| for 1h; Reflux; | 85% |

benzaldehyde


2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

| Conditions | Yield |
|---|---|
| In ethanol Reflux; | 81% |

4-methoxy-benzaldehyde


2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

| Conditions | Yield |
|---|---|
| In ethanol Reflux; | 71% |

2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide


acetophenone

| Conditions | Yield |
|---|---|
| In ethanol for 3h; Reflux; | 69% |

3-pyridinecarboxaldehyde


2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide

| Conditions | Yield |
|---|---|
| In ethanol Reflux; | 62% |