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7803-57-8

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Basic Information
CAS No.: 7803-57-8
Name: Hydrazine hydrate
Article Data: 13
Molecular Structure:
Molecular Structure of 7803-57-8 (Hydrazine hydrate)
Formula: H4N2.H2O
Molecular Weight: 50.0604
Synonyms: Hydrazyna [Polish];RCRA waste no. U133;Hydrazines;Hydrazine base;Hydrazine, aqueous solution with not >37% hydrazine, by mass [UN3293] [Poison];Hydrazine hydrate 80%;hydrazine--water (1/1);RCRA waste number U133;Hydrazine, anhydrous or hydrazine aqueous solutions with >64% hydrazine, by mass [UN2029] [Corrosive];Diamine;Nitrogen hydride;Hydrazine monohydrate;Hydrazine (anhydrous);Hydrazine, anhydrous;Hydrazinehydrate;80%Hydrazinehydrade;NaAc;Hydrazines hydrate;Hydrazine hydrate80%;
EINECS: 206-114-9
Density: 1.032
Melting Point: -52 °C
Boiling Point: 120-121 °C
Flash Point: 75 °C (167 °F)
Solubility: miscible
Appearance: colorless fuming liquid with a faint ammonia-like odor
Hazard Symbols: ToxicT,DangerousN
Risk Codes: 45-20/21/22-34-43-51/53-50/53-23/24/25-10
Safety: 53-45-60-61
Transport Information: UN 3293 6.1/PG 3
PSA: 61.27000
LogP: 0.15510
Synthetic route
13466-30-3

(1-phenylethylidene)hydrazine

moist air

moist air

A

7803-57-8

hydrazine hydrate

B

729-43-1

acetophenonazine

7647-01-0

hydrogenchloride

50-00-0

formaldehyd

5397-03-5

hydrazinecarbodithioic acid methyl ester

A

5-methylsulfanyl-[1,3,4]thiadiazole-3-carbodithioic acid methyl ester

B

7803-57-8

hydrazine hydrate

7664-93-9

sulfuric acid

bis-[1-(6-hydroxy-[2]naphthyl)-ethylidene]-hydrazine

64-19-7

acetic acid

A

7803-57-8

hydrazine hydrate

B

6-aceto-naphthol-(2)

6-aceto-naphthol-(2)

56004-08-1

N-amino-N',N''-diphenyl-guanidine

A

7803-57-8

hydrazine hydrate

B

62-53-3

aniline

C

triphenylguanazole

triphenylguanazole

Conditions
ConditionsYield
at 180℃;

hydroxide

14380-61-1

hypochlorite

A

16887-00-6

chloride

B

3812-32-6

carbonate(2-)

C

7803-57-8

hydrazine hydrate

Conditions
ConditionsYield
In not given in alk. soln.;
13598-47-5

sodium hydrazide

A

7803-57-8

hydrazine hydrate

B

1310-73-2

sodium hydroxide

Conditions
ConditionsYield
With ethanol; water In benzene byproducts: sodium alcoholate; decompn. of NaNH*NH2 without explosion: pouring greater amounts of dry benzene over NaNH*NH2 under N2 atmosphere, then addn. of small amounts of alcoholic benzene by shaking until solid substance has reacted; addn. of water;;
5921-54-0

butan-2-one azine

7803-57-8

hydrazine hydrate

Conditions
ConditionsYield
at 160 - 190℃; under 7500.75 - 8250.83 Torr; pH=8.2 - 8.5; Inert atmosphere; Industrial scale;
7727-37-9

nitrogen

A

7664-41-7

ammonia

B

7803-57-8

hydrazine hydrate

Conditions
ConditionsYield
With potassium hydroxide In water at 20℃; under 760.051 Torr; Reagent/catalyst; Electrochemical reaction;
7727-37-9

nitrogen

A

7664-41-7

ammonia

B

7803-57-8

hydrazine hydrate

Conditions
ConditionsYield
With lithium perchlorate at 20℃; for 10h; pH=6.5; Reagent/catalyst; Electrochemical reaction;
7727-37-9

nitrogen

1333-74-0

hydrogen

A

7664-41-7

ammonia

B

7803-57-8

hydrazine hydrate

Conditions
ConditionsYield
With hydrogenchloride pH=1; Reagent/catalyst; Electrochemical reaction;
Raw Materials
13466-30-3
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Standards and Recommendations

NIOSH REL: (Hydrazines) CL 0.03 ppm/120M

Specification

Hydrazine hydrate with cas registry number of 7803-57-8 is a colorless fuming liquid with a faint ammonia-like odor. It also has other registry numbers including 65209-65-6, 65492-74-2, 79785-97-0. Its EINECS registry number is 206-114-9. This chemical is stable, but incompatible with a wide variety of materials, including oxidizing agents, heavy metal oxides, dehydrating agents, alkali metals, rust, silver salts. It belongs to the following categories: Biochemistry; Reagents for Oligosaccharide Synthesis; Synthetic Organic Chemistry; Water Ttreatment Chemicals. In addition, this chemical has a systematic name which is called hydrazine hydrate (1:1). And its IUPAC name is called hydrazine hydrate.

The physical properties about this chemical are: (1)ACD/LogP: -1.20; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.73; (4)ACD/LogD (pH 7.4): -2.04; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1 ; (7)#H bond acceptors: 2; (8)#H bond donors: 4; (9)#Freely Rotating Bonds: 1; (10)Enthalpy of Vaporization: 41.8 kJ/mol; (11)Boiling Point: 113.5 °C at 760 mmHg; (12)Vapour Pressure: 20.7 mmHg at 25°C.

Preparation of Hydrazine hydrate: There are several methods to prepare this chemical. For example, it can be made by urea. First, mix the sodium hypochlorite and sodium hydroxide by a certain percentage. And add the mixture of urea and a small amount of potassium permanganate while stirring. Second, pass the steam directly into reactor at the temperature of 103 ~ 104 ℃. The oxidation reaction begins. Third, obtaine 40% hydrazine hydrate by fractional distillation and vacuum concentration. At last, 80% hydrazine hydrate is prepared by dehydration with caustic soda, vacuum distillation. The reaction is as follows:
NH2ONH2 + NaC1O +2 NaOH → N2H4.H2O + NaC1 + Na2CO3

Uses: It is used as reductant for hydrazine hydrate, medicine, pesticides, dyes, foaming agents, imaging agent, antioxidant materials. It is also used in the manufacture of high-purity metal, synthetic fiber, the separation of rare. In addition, the material can be used to manufacture rockets and explosives.

When you are using this chemical, please be cautious about it as the following:
This chemical causes burns. It also may cause cancer and sensitization by skin contact. The most important thing is that it is very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Therefore, avoid exposure  before use. And avoid release to the environment. This material and its container must be disposed of as hazardous waste. In case of accident or if you feel unwell, seek medical advice immediately.

You can still convert the following datas into molecular structure:
(1)SMILES: O.NN;
(2)InChI: InChI=1/H4N2.H2O/c1-2;/h1-2H2;1H2;
(3)InChIKey: IKDUDTNKRLTJSI-UHFFFAOYAN

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 40mg/kg (40mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Hygiene and Sanitation Vol. 30(7-9), Pg. 191, 1965.
mouse LD50 intraperitoneal 156mg/kg (156mg/kg)   Cancer Research. Vol. 41, Pg. 1469, 1981.
mouse LD50 oral 83mg/kg (83mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Hygiene and Sanitation Vol. 30(7-9), Pg. 191, 1965.
rabbit LD50 oral 55mg/kg (55mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Hygiene and Sanitation Vol. 30(7-9), Pg. 191, 1965.
rat LD50 oral 129mg/kg (129mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Hygiene and Sanitation Vol. 30(7-9), Pg. 191, 1965.