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| CAS No.: | 78281-72-8 |
|---|---|
| Name: | Nepafenac |
| Article Data: | 8 |
| Cas Database | |
| Molecular Structure: | |
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| Formula: | C15H14N2O2 |
| Molecular Weight: | 254.288 |
| Synonyms: | Benzoic acid,3-fluoro-2-iodo-;AHR 9434;AL 6515;Nevanac; |
| Density: | 1.249 g/cm3 |
| Melting Point: | 177-181oC |
| Boiling Point: | 562.5 °C at 760 mmHg |
| Flash Point: | 294 °C |
| Solubility: | 0.014 mg/mL in water |
| Hazard Symbols: | N |
| Risk Codes: | 50/53 |
| Safety: | 60-61 |
| PSA: | 86.18000 |
| LogP: | 2.80910 |
- 78287-27-11H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4,11-diethyl-4-hydroxy-,(4S)-
- 782-87-6Propanenitrile,3,3'-[(phenylmethyl)imino]bis-
- 78291-25-5Ethanol,2-[(5-nitro-2-benzothiazolyl)amino]-
- 782-92-3Ethanone,1-[4-(phenylmethyl)phenyl]-
- 78299-75-91H-Indazole,5-(phenylmethoxy)-
- 78301-05-0Diazene,bis(2,6-dimethylphenyl)-, 1,2-dioxide, (E)- (9CI)
- 78301-72-11,2,3-Thiadiazol-5-amine,4-phenyl-
- 78303-09-0Benzoicacid, 3-(4-methylphenoxy)-, methyl ester
- 78306-92-01-Naphthalenepropanoicacid, a-amino-, (aR)-
- 78-30-8Phosphoric acid,tris(2-methylphenyl) ester
- 78281-61-5
2-amino-3-benzoyl-α-(methylthio)benzeneacetamide
- 78281-72-8
nepafenac
| Conditions | Yield |
|---|---|
| nickel In tetrahydrofuran; water at 20℃; for 0.166667h; Product distribution / selectivity; | 86% |
| With Raney nickel In tetrahydrofuran at -5 - 5℃; for 0.5h; | 78.8% |
| With nickel In tetrahydrofuran for 0.25h; | 73% |
- 2835-77-0
(2-aminophenyl)(phenyl)methanone
- 78281-72-8
nepafenac
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 1.) tert-butyl hypochlorite, 2.) triethylamine / 1.) CH2Cl2, THF, -60 deg C, 1 h, 2.) CH2Cl2, 5 min 2: 73 percent / Raney nickel / tetrahydrofuran / 0.25 h View Scheme |
- 173262-94-7
2-amino-3-benzoyl-α-(1-propylthio)-benzeneacetamide
- 78281-72-8
nepafenac
- 78281-72-8
nepafenac
- 51135-38-7
7-benzoyl-1,3-dihydroindol-2-one
| Conditions | Yield |
|---|---|
| With hydrogenchloride In ethanol; water at 30℃; for 3h; Temperature; Reagent/catalyst; Solvent; | 92.1% |
| With hydrogenchloride In ethanol Heating; |
- 78281-72-8
nepafenac
- 1246956-18-2
2-{2-amino-3-[hydroxy(phenyl)methyl]phenyl}acetamide
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate; ethanol for 2h; Reflux; | 75% |
| Conditions | Yield |
|---|---|
| With sodium cyanoborohydride In acetic acid; acetonitrile |
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- 723-46-6Sulfamethoxazole
- 67-47-02-Furancarboxaldehyde,5-(hydroxymethyl)-
- 3286-46-2Sulbutiamine
- 4075-81-4Propanoicacid, calcium salt (2:1)
- 25812-30-0Gemfibrozil
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
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Chemistry
Product Name: Nepafenac (CAS NO.78281-72-8)
Molecular Formula: C15H14N2O2
Molecular Weight: 254.28g/mol
Mol File: 78281-72-8.mol
Boiling point: 562.5 °C at 760 mmHg
Flash Point: 294 °C
Density: 1.249 g/cm3
Surface Tension: 58.8 dyne/cm
Enthalpy of Vaporization: 84.56 kJ/mol
Vapour Pressure: 1.11E-12 mmHg at 25°C
XLogP3-AA: 1.9
H-Bond Donor: 2
H-Bond Acceptor: 3
Structure Descriptors of Nepafenac (CAS NO.78281-72-8):
IUPAC Name: 2-(2-amino-3-benzoylphenyl)acetamide
Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=C(C(=CC=C2)CC(=O)N)N
InChI: InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
InChIKey: QEFAQIPZVLVERP-UHFFFAOYSA-N
Classification Code: Topical ocular anti-inflammatory and analgesic
Specification
Nepafenac , its CAS NO. is 78281-72-8, the synonyms are 2-(2-Amino-3-benzoylphenyl)acetamide ; 2-Amino-3-benzoylbenzeneacetamide ; AHR 9434 ; Nevanac ; UNII-0J9L7J6V8C ; Benzeneacetamide, 2-amino-3-benzoyl- .
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