CAS No.799274-08-1,6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	799274-08-1
Name:	6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

Formula:	C₉H₁₀FN^.HCl
Molecular Weight:	187.644
Synonyms:	Isoquinoline,6-fluoro-1,2,3,4-tetrahydro-, hydrochloride (9CI);Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro-, hydrochloride;
PSA:	12.03000
LogP:	2.60220

Synthetic route

: 799274-08-1
6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1018826-70-4
tert-butyl 4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; N-tert-butyloxycarbonylpiperidin-4-one With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h; Molecular sieve; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 18h;	94%

: 799274-08-1
6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 2369-11-1
5-fluoro-2-nitroaniline

: 5-(7-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2-nitroaniline

Conditions

Conditions	Yield
With iodine; triethylamine In dimethyl sulfoxide for 1.5h; Reflux; Inert atmosphere;	84%

: 1009344-67-5
N-(4-bromo-2,6-dimethylphenyl)-3,3-dimethylbutanamide

: 799274-08-1
6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1009344-33-5
N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide

Conditions

Conditions	Yield
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In toluene at 80℃;	83%
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In 2-methyltetrahydrofuran at 77℃; for 13h; Inert atmosphere;

: 211693-73-1
2-amino-3,4-difluoronitro-benzene

: 799274-08-1
6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 2-fluoro-3-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-6-nitroaniline

Conditions

Conditions	Yield
With iodine; triethylamine In dimethyl sulfoxide for 3h; Reflux; Inert atmosphere;	74%

: 799274-08-1
6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 2369-11-1
5-fluoro-2-nitroaniline

: 5-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2-nitroaniline

Conditions

Conditions	Yield
With iodine; triethylamine In dimethyl sulfoxide for 1.5h; Reflux; Inert atmosphere;	72%

: 799274-08-1
6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1323407-86-8
3-[4-[[4-(bromomethyl)phenyl]methoxy]-1-oxo-isoindolin-2-yl]piperidine-2,6-dione

: 1323403-99-1
3-{4-[4-(6-Fluoro-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-benzyloxy]-1-oxo-1,3-dihydro-isoindol-2-yl}-piperidine-2,6-dione

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	69%

: 799274-08-1
6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 6-methyl-4-(methylthio)-1-{[5-(trifluoromethyl)thiophen-2-yl]methyl}-1,3,5-triazin-2(1H )-one

: 4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-6-methyl-1-{[5-(trifluoromethyl)thiophen-2-yl]methyl}-1,3,5-triazin-2(1H)-one

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane for 14h; Reflux;	26%
With triethylamine In 1,4-dioxane for 14h; Reflux;	26%

: 1009344-69-7
N-(4-Bromo-2-chloro-6-trifluoromethyl-phenyl)-3-cyclopentyl-propionamide

: 799274-08-1
6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1009344-27-7
N-[2-Chloro-4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-6-trifluoromethyl-phenyl]-3-cyclopentyl-propionamide

Conditions

Conditions	Yield
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In toluene at 90℃;

: 1009344-73-3
N-(4-Bromo-2-chloro-6-methylphenyl)-3,3-dimethyl butanamide

: 799274-08-1
6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1009344-39-1
N-[2-chloro-4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-6-methylphenyl]-3,3-dimethylbutanamide

Conditions

Conditions	Yield
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In toluene at 90℃;

: 799274-08-1
6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 24424-99-5
di-tert-butyl dicarbonate

: tert-butyl 6-fluoro-3,4-dihydroisoquinoline-2(1H)-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran; water at 20℃; for 18h;

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Specification

The 6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride, with the CAS registry number 799274-08-1, is also known as Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro-, hydrochloride. This chemical's molecular formula is C₉H₁₀FN^.HCl and molecular weight is 187.64. What's more, its systematic name is 6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1).

You can still convert the following datas into molecular structure:
(1)SMILES: c1cc2c(cc1F)CCNC2.Cl
(2)Std. InChI: InChI=1S/C9H10FN.ClH/c10-9-2-1-8-6-11-4-3-7(8)5-9;/h1-2,5,11H,3-4,6H2;1H
(3)Std. InChIKey: YXZXFMKDFFJUCA-UHFFFAOYSA-N