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| CAS No.: | 80-11-5 |
|---|---|
| Name: | N-Methyl-N-nitrosotoluene-4-sulphonamide |
| Article Data: | 18 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H10N2O3S |
| Molecular Weight: | 214.245 |
| Synonyms: | p-Toluenesulfonamide,N-methyl-N-nitroso- (6CI,7CI,8CI);Diazald;Diazale;N-Methyl-N-nitroso-4-tosylamide;N-Nitroso-N-methyl-p-toluenesulfonamide;NSC 313;p-Tolylsulfonylmethylnitrosamide; |
| EINECS: | 201-252-6 |
| Density: | 1.3 g/cm3 |
| Melting Point: | ~58 °C |
| Boiling Point: | 320.5 °C at 760 mmHg |
| Flash Point: | 147.6 °C |
| Appearance: | pale yellow crystalline powder |
| Hazard Symbols: |
 E, Xi, Xn
|
| Risk Codes: | 2-36/37/38-43-20/21/22 |
| Safety: | 15-26-35-36/37-36 |
| Transport Information: | UN 3234 4.1/PG 2 |
| PSA: | 75.19000 |
| LogP: | 2.37770 |
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| Conditions | Yield |
|---|---|
| With hydrogenchloride; water; sodium nitrite In diethyl ether | 81% |
| With perchloric acid; sodium nitrite In dichloromethane; water Rate constant; Equilibrium constant; nitrosation of substituted N-methylbenzenesulfonamides; reversibility; kinetics of nitrosation and denitrosation; substituent effect; acid catalysis; effect of nucleophiles; mechanism; | |
| With dinitrogen tetraoxide |
| Conditions | Yield |
|---|---|
| With sodium hydroxide Behandeln des Reaktionsgemisches mit Essigsaeure und NaNO2; |
- 67764-33-4
cyclopentyl nitrite
- 640-61-9
N-methyl-p-toluenesulfonylamide
- 80-11-5
N-methyl-N-nitrosotoluene-p-sulfonamide
| Conditions | Yield |
|---|---|
| With diluted acid |
- 22547-51-9
1-methyl-1-(4-tolylsulfonyl)hydrazine
- 80-11-5
N-methyl-N-nitrosotoluene-p-sulfonamide
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid; sodium nitrite |
- 98-59-9
p-toluenesulfonyl chloride
- 3058-37-5
(Z)-potassium methanediazotate
- 80-11-5
N-methyl-N-nitrosotoluene-p-sulfonamide
| Conditions | Yield |
|---|---|
| In diethyl ether |
- 103999-21-9
C8H10NO2S(1-)
- 80-11-5
N-methyl-N-nitrosotoluene-p-sulfonamide
| Conditions | Yield |
|---|---|
| With nitrosonium perchlorate In acetonitrile at 25℃; Thermodynamic data; |
- 80-11-5
N-methyl-N-nitrosotoluene-p-sulfonamide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: trifluoroacetic acid / neat (no solvent) / 1 h / 0 - 23 °C 2: sodium chloride; sodium acetate; sodium nitrite; acetic acid / water / 0.25 h / 0 °C View Scheme |
| Conditions | Yield |
|---|---|
| With sulfite(2-) In 1,4-dioxane; water at 25℃; Rate constant; | 100% |
| With Thiocyanate In 1,4-dioxane; water at 25℃; Rate constant; | 100% |
| With thiourea In 1,4-dioxane; water at 25℃; Rate constant; | 100% |
- 80-11-5
N-methyl-N-nitrosotoluene-p-sulfonamide
- 47173-80-8
N-Boc-D-serine(Bzl)-OH
- 67389-47-3
(R)-3-benzyloxy-2-tert-butoxycarbonyl-amino-propionic acid methyl ester
| Conditions | Yield |
|---|---|
| 99% |
- 2941-78-8
2-Amino-5-methylbenzoic acid
- 80-11-5
N-methyl-N-nitrosotoluene-p-sulfonamide
- 18595-16-9
2-amino-5-methylbenzoic acid methyl ester
| Conditions | Yield |
|---|---|
| Stage #1: N-methyl-N-nitrosotoluene-p-sulfonamide With potassium hydroxide In diethyl ether; water Stage #2: 2-Amino-5-methylbenzoic acid In diethyl ether for 1h; | 99% |
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Chemistry
Molecular Formula: C8H10N2O3S
Molecular Weight: 214.24
EINECS: 201-252-6
Density: 1.3 g/cm3
Flash Point: 147.6 °C
Storage temp: 2-8°C
Index of Refraction: 1.572
Enthalpy of Vaporization: 56.22 kJ/mol
Boiling Point: 320.5 °C at 760 mmHg
Vapour Pressure: 0.000317 mmHg at 25°C
Appearance: pale yellow crystalline powder
Product Categories: Pharmaceutical Intermediates
Stability: Stable, but heat sensitive; may also be light sensitive. Incompatible with strong oxidizing agents, alkalies.
Synonyms: Benzenesulfonamide, N,4-dimethyl-N-nitroso- ; Benzenesulfonamide,N,4-dimethyl-N-nitroso- ; Diazale;diazalo ; Methylnitroso-p-toluenesulfonamide ; N,4-dimethyl-n-nitroso-benzenesulfonamid ; N,4-dimethyl-N-nitroso-Benzenesulfonamide ; N,4-Dimethyl-N'-oxobenzenesulfonohydrazide
Following is the molecular structure of N-Methyl-N-Nitroso-P-Toluene Sulfonamide (80-11-5):
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Toxicity Data With Reference
The toxicity of N-Methyl-N-Nitroso-P-Toluene Sulfonamide (80-11-5):
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 19mg/kg (19mg/kg) | Cancer Research. Vol. 30, Pg. 11, 1970. | |
| rat | LD50 | oral | 2700mg/kg (2700mg/kg) | Naturwissenschaften. Vol. 48, Pg. 165, 1961. |
Safety Profile
Safety Information of N-Methyl-N-Nitroso-P-Toluene Sulfonamide (80-11-5):
Hazard Codes: E,Xi,Xn
E: Explosive .gif){kind=small}
Xn: Harmful .gif){kind=small}
Xi: Irritant .gif)
Risk Statements: 2-36/37/38-43-20/21/22
2: Risk of explosion by shock, friction, fire or other sources of ignition
36/37/38: Irritating to eyes, respiratory system and skin
43: May cause sensitization by skin contact
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements: 15-26-35-36/37-36
15: Keep away from heat
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
35: This material and its container must be disposed of in a safe way
36/37: Wear suitable protective clothing and gloves
36: Wear suitable protective clothing
RIDADR: UN 3234 4.1/PG 2
WGK Germany: 2
RTECS: XT5950000
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 80-11-5(Hazardous Substances Data)