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| CAS No.: | 8008-94-4 |
|---|---|
| Name: | LICORICE EXTRACT |
| Molecular Structure: | |
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| Formula: | N/A |
| Molecular Weight: | 0 |
| Synonyms: | LIQUORICE EXTRACT;LICORICE ROOT;LICORICE ROOT EXTRACT;LICORICE ROOT FLUID EXTRACT;LICORICE ROOT POWDER;GLYCYRRHIZA GLABRA POWDER;GLYCYRRHIZA GLABRA ROOT POWDER;FEMA 2628 |
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Chemistry
Product Name: Licorice extract (CAS NO.8008-94-4)
Mol File: 8008-94-4.mol
Uses
GB 2760-96: allowing the use of edible spices. Sweeteners; flavoring agent; surfactant.
Production
Legumes take licorice (GlycyrRhiza uralensis), Glycyrrhiza inflata (G. Inflata) or foreign liquorice (G. Glabra) dry root and rhizome to remove fibrous root dry raw materials. With less than 60 ℃: warm water immersion, cut into 0.5cm slices below, plus 8 times the amount of water, boil countercurrent extraction cycle 8 times, the leaching solution set of natural sedimentation sedimentation tank 3h, the supernatant concentrated to thick paste , so that glycyrrhizic acid content is not less than 20% of the degrees, is a licorice extract. Amount of licorice extract obtained by adding water, constantly stirring and heating to make it melt, filter, in the filtrate slowly adding 85% ethanol to the solution of ethanol content of 65% or so, put it aside overnight, the supernatant, the remaining precipitation coupled with 65% ethanol, stirring, overnight, the supernatant, plus 65% ethanol extract of a merger three extract filtration, recovery of ethanol, water and ethanol to more than 7.0% glycyrrhizin content, ethanol content of 20% to 25%, with Ph value of ammonia solution adjusted to 7.5 ~ 8.5, put it aside, to clarify the supernatant filter formed.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 209gm/kg/2Y-I (209000mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: MUSCLE WEAKNESS CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE | Italian Journal of Neurological Sciences. Vol. 4, Pg. 493, 1983. |
| mouse | LD50 | intraperitoneal | 1500mg/kg (1500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: CHANGES IN SPLEEN | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977. |
| mouse | LD50 | oral | > 7500mg/kg (7500mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977. | |
| mouse | LD50 | subcutaneous | 4gm/kg (4000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: CHANGES IN SPLEEN | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977. |
| rat | LD50 | intraperitoneal | 1420mg/kg (1420mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977. |
| rat | LD50 | oral | 14200mg/kg (14200mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977. |
| rat | LD50 | subcutaneous | 4200mg/kg (4200mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977. |
Safety Profile
Moderately toxic by intraperitoneal and subcutaneous routes. Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Specification
Licorice extract ,its CAS NO. is 8008-94-4,the synonyms is Licorice root ; Licorice root extract ; Licorice root fluid extract ; Licorice root powder ; Glycyrrhiza glabra powder ; Glycyrrhiza glabra root powder ; Fema 2628 .