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| CAS No.: | 80573-04-2 |
|---|---|
| Name: | Balsalazide |
| Article Data: | 5 |
| Molecular Structure: | |
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| Formula: | C17H15N3O6 |
| Molecular Weight: | 357.323 |
| Synonyms: | Colazide;Benzoic acid,5-[(1E)-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]azo]-2-hydroxy- (9CI);Benzoic acid, 5-[[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]azo]-2-hydroxy-,(E)-;Balsalazida;Balsalazido;Balsalazidum; |
| EINECS: | 617-116-8 |
| Density: | 1.44 g/cm3 |
| Melting Point: | 254-255 °C |
| Boiling Point: | 729.6±60.0 °C(Predicted) |
| Appearance: | yellow solid |
| Risk Codes: | R20/21/22 |
| PSA: | 148.65000 |
| LogP: | 3.10120 |
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Chemistry
Molecular Formula of Balsalazide (CAS NO.80573-04-2): C17H15N3O6
Molecular Weight: 357.32 g/mol
Index of Refraction: 1.649
Density: 1.44 g/cm3
Structure of Balsalazide (CAS NO.80573-04-2):
IUPAC Name: (3Z)-3-[[4-(2-Carboxyethylcarbamoyl)phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylic acid
Uses
Balsalazide (CAS NO.80573-04-2) has been used as an anti-inflammatory drug in the treatment of inflammatory bowel disease.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD | oral | > 4gm/kg (4000mg/kg) | Drugs of the Future. Vol. 9, Pg. 313, 1984. | |
| rat | LD | oral | > 2gm/kg (2000mg/kg) | Drugs of the Future. Vol. 9, Pg. 313, 1984. | |
| women | TDLo | oral | 1080mg/kg/8D- (1080mg/kg) | CARDIAC: PERICARDITIS LUNGS, THORAX, OR RESPIRATION: DYSPNEA LIVER: "JAUNDICE, CHOLESTATIC" | British Medical Journal. Vol. 320, Pg. 613, 2000. |
Specification
Balsalazide , its cas register number is 80573-04-2. It also can be called (E)-5-[[4-[[(2-Carboxyethyl)amino]-carbonyl]phenyl]azo-2-hydroxybenzoic acid ; and Balsalazide Disodium . It is sold in generic form in the US by several generic manufacturers, and is usually administered as the disodium salt. Its advantage over that drug in the treatment of Ulcerative colitis is believed to be the delivery of the active agent past the small intestine to the large intestine.