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8063-14-7

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Basic Information
CAS No.: 8063-14-7
Name: Cannabis
Molecular Structure:
Molecular Structure of 8063-14-7 (Cannabis)
Formula: N/A
Molecular Weight: 0
Synonyms: Hemp
Hazard Symbols: A mild hallucinogen. Sale is illegal in U.S.
Safety: Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Human systemic effects by ingestion include: change in heart rate, change in cardiac resting or action potential, and blood pressure decrease. Human mutation data reported. An allergen. When ingested or inhaled as smoke, it can cause euphoria, delirium, hallucinations, drowsiness, weakness, and hyporeflexia. An overdose can cause coma and death. Dried material can burn; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx. See also THC.
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Chemistry

Chemistry informtion about Cannabis (CAS NO.8063-14-7) is:
Synonyms:  Cannabis extract ; Cannabis resin ; Cannabis sativa ; Cannabis sativa extract ; Cannabis sativa resin ; Charas ; Ganja ; Grass 
Classification Code: Human Data; Mutation data; Reproductive Effect

History

 Cannabis is native to tropical and temperate climates, but is cultivated around the world. Modern illicit growing operations use sophisticated methods to produce high potency marijuana. People with a medical exemption from Health Canada may grow their own supply or designate someone to grow it for them. Research-grade cannabis is grown by a producer appointed by the federal government.

Uses

 Cannabis (CAS NO.8063-14-7) is the most widely used illegal drug in Britain. Made from parts of the cannabis plant, it's a naturally occurring drug. It is a mild sedative (often causing a chilled out feeling or actual sleepiness) and it's also a mild hallucinogen (meaning you may experience a state where you see objects and reality in a distorted way and may even hallucinate).

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 5gm/kg (5000mg/kg) lungs, thorax, or respiration: acute pulmonary edema Toxicology and Applied Pharmacology. Vol. 25, Pg. 363, 1973.
human TDLo oral 60mg/kg/20D (60mg/kg) cardiac: change in rate cardiac: change in resting or action potential vascular: bp lowering not characterized in autonomic section British Medical Journal. Vol. 1, Pg. 460, 1978.
monkey LD oral > 5gm/kg (5000mg/kg)   Toxicology and Applied Pharmacology. Vol. 25, Pg. 363, 1973.
mouse LDLo intraperitoneal 5gm/kg (5000mg/kg)   Nature. Vol. 228, Pg. 134, 1970.
rat LD50 oral 1380mg/kg (1380mg/kg)
behavioral: somnolence (general depressed activity) lungs, thorax, or respiration: respiratory depression
Toxicology and Applied Pharmacology. Vol. 25, Pg. 363, 1973.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Human systemic effects by ingestion include: change in heart rate, change in cardiac resting or action potential, and blood pressure decrease. Human mutation data reported. An allergen. When ingested or inhaled as smoke, it can cause euphoria, delirium, hallucinations, drowsiness, weakness, and hyporeflexia. An overdose can cause coma and death. Dried material can burn; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx. See also THC.

Specification

 Cannabis (CAS NO.8063-14-7) is an annual, dioecious, flowering herb. The leaves are palmately compound or digitate, with serrate leaflets. The first pair of leaves usually have a single leaflet, the number gradually increasing up to a maximum of about thirteen leaflets per leaf (usually seven or nine), depending on variety and growing conditions. At the top of a flowering plant, this number again diminishes to a single leaflet per leaf. The lower leaf pairs usually occur in an opposite leaf arrangement and the upper leaf pairs in an alternate arrangement on the main stem of a mature plant. Cannabis normally has imperfect flowers, with staminate "male" and pistillate "female" flowers occurring on separate plants. It is not unusual, however, for individual plants to bear both male and female flowers. Although monoecious plants are often referred to as "hermaphrodites," true hermaphrodites (which are less common) bear staminate and pistillate structures on individual flowers, whereas monoecious plants bear male and female flowers at different locations on the same plant. Male flowers are normally borne on loose panicles, and female flowers are borne on racemes. All known strains of Cannabis are wind-pollinated and produce "seeds" that are technically called achenes. Most strains of Cannabis are short day plants, with the possible exception of C. sativa subsp. sativa var. spontanea (= C. ruderalis), which is commonly described as "auto-flowering" and may be day-neutral. Cannabis, like many organisms, is diploid, having a chromosome complement of 2n=20, although polyploid individuals have been artificially produced.The plant is believed to have originated in the mountainous regions northwest of the Himalayas. It is also known as hemp, although this term is often used to refer only to varieties of Cannabis cultivated for non-drug use. Cannabis plants produce a group of chemicals called cannabinoids, which produce mental and physical effects when consumed. Cannabinoids, terpenoids, and other compounds are secreted by glandular trichomes that occur most abundantly on the floral calyxes and bracts of female plants. As a drug it usually comes in the form of dried flower buds (marijuana), resin (hashish), or various extracts collectively known as hashish oil. In the early 20th century, it became illegal in most of the world to cultivate or possess Cannabis for drug purposes.