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81103-11-9

Basic Information
CAS No.: 81103-11-9
Name: Clarithromycin
Molecular Structure:
Molecular Structure of 81103-11-9 (Clarithromycin)
Formula: C38H69NO13
Molecular Weight: 747.96 .
Synonyms: Adel;Mabicrol;TE 031;Klaricid;Biaxin (TN);(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-6-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-14-ethyl-12,13-dihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione;Clarithromycine [INN-French];Clacine;Trovafloxacin & Clarithromycin;6-o-Methoxyerythromycin;(3R,4S,6R,7R,9R,11R,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione;Abbott-56268;Clarith;Klacid;Claritromicina [INN-Spanish];Klaciped;6-O-Methylerythromycin A;Kofron;Heliclar;Klarin;TE-031;TE031;Maclar;Klaricid Pediatric;Biaxin;(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione;Helas;Veclam;Klarid;Clathromycin;Zeclar;Clarithromycinum [INN-Latin];Claribid;Klax;Mavid;
EINECS: 1806241-263-5
Density: 1.184 g/cm3
Melting Point: 217-220 °C
Boiling Point: 805.478 °C at 760 mmHg
Flash Point: 440.937 °C
Solubility: 99.48mg/L(20 oC)
Appearance: Colourless crystalline needles
Hazard Symbols: HarmfulXn, IrritantXi
Risk Codes: 22-36/37/38
Safety: 26-36
Transport Information:
PSA: 182.91000
LogP: 2.43970
Synthetic route
118074-07-0

6-O-methylerythromycin A N-oxide

81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: 6-O-methylerythromycin A N-oxide With tin(ll) chloride In isopropyl alcohol at 30 - 40℃; for 2h;
Stage #2: With sodium hydrogencarbonate In water; isopropyl alcohol
96%
With bis(tri-n-butyltin) In tetrahydrofuran for 24h; Heating / reflux;95%
With hydrogen; W4 Raney-nickel In ethanol at 40 - 50℃; for 3h;92%
With potassium hydroxide; nickel-aluminum alloy In methanol; water at 35 - 40℃; for 3.5h;92%
Stage #1: 6-O-methylerythromycin A N-oxide With tin(ll) chloride In dichloromethane at 20℃; for 1.5h;
Stage #2: With sodium carbonate In dichloromethane; water
32%
930287-49-3

clarythromycin 9-O-(2-pyrimidyl)oxime

81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium hydrogensulfite In ethanol; water at 80℃; for 6h;95%
50-00-0

formaldehyd

118074-07-0

6-O-methylerythromycin A N-oxide

81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: 6-O-methylerythromycin A N-oxide With sodium hydrogensulfite In ethanol; water at 20℃; for 1h;
Stage #2: With sodium carbonate In ethanol; water
Stage #3: formaldehyd With formic acid; sodium carbonate more than 3 stages;
92%
Stage #1: 6-O-methylerythromycin A N-oxide With sodium hydrogensulfite In ethanol; water at 20℃; for 1h;
Stage #2: With sodium carbonate In ethanol; water
Stage #3: formaldehyd With formic acid; ammonia more than 3 stages;
30%
81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium disulfide In ethanol Heating;68%
130034-54-7

9-deoxo-9-imino-6-O-methylerythromycin A

81103-11-9

clarithromycin

Conditions
ConditionsYield
With water In methanol at 23℃; pH 12.4 or pH 7;
With hydrogenchloride; water In ethanol pH=5 - 6;

2',4''-[O-bis(trimethylsilyl)]clarithromycin 9-[O-(dimethylthexylsilyl)oxime]

81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium metabisulfite; formic acid In ethanol for 0.5h; Hydrolysis; Heating;4.32 g
930287-46-0

6-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydro-pyran-2-yloxy)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-(O-pyrimidin-2-yl-oxime)

81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / trimethylsilyl-imidazole / CH2Cl2 / 2 h / 0 °C
2: 83 percent / KOH / dimethylsulfoxide
3: 97 percent / HCO2H / ethanol; H2O
4: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C
View Scheme
930287-48-2

C48H88N4O13Si2

81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / HCO2H / ethanol; H2O
2: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C
View Scheme
930287-47-1

2',4''-O-bistrimethylsilyl erythromycin A 9-O-(2-pyrimydyl)oxime

81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 83 percent / KOH / dimethylsulfoxide
2: 97 percent / HCO2H / ethanol; H2O
3: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C
View Scheme

erythromycin A (9E)-oxime hydrochloride

81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 93 percent / t-BuOK / 2 h / 80 °C
2: 90 percent / trimethylsilyl-imidazole / CH2Cl2 / 2 h / 0 °C
3: 83 percent / KOH / dimethylsulfoxide
4: 97 percent / HCO2H / ethanol; H2O
5: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C
View Scheme
127253-06-9

6-methoxyerythromycin A 9-oxime

81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 25 percent / Bu3P / tetrahydrofuran; dioxane
2: H2O; HCl / ethanol / pH 5 - 6
View Scheme
Multi-step reaction with 2 steps
1.1: PySeSePy; Me3P / tetrahydrofuran / 0.17 h / 0 °C
1.2: 80 percent / H2O / pH 10
2.1: H2O; HCl / ethanol / pH 5 - 6
View Scheme
111321-02-9

erythromycin A 9-(E)-oxime

81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / Et3N / dimethylformamide / 1 h / 20 °C
2: 95.1 percent / 1-trimethylsilylimidazole / ethyl acetate / 1 h / 20 °C
3: 8.82 g / NaH / tetrahydrofuran; dimethylsulfoxide / 1 h / 0 - 5 °C
4: 4.32 g / formic acid; Na2S2O5 / ethanol / 0.5 h / Heating
View Scheme

erythromycin A 9-[O-(dimethylthexylsilyl)oxime]

81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95.1 percent / 1-trimethylsilylimidazole / ethyl acetate / 1 h / 20 °C
2: 8.82 g / NaH / tetrahydrofuran; dimethylsulfoxide / 1 h / 0 - 5 °C
3: 4.32 g / formic acid; Na2S2O5 / ethanol / 0.5 h / Heating
View Scheme

2',4''-[O-bis(trimethylsilyl)]erythromycin A 9-[O-(dimethylthexylsilyl)oxime]

81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 8.82 g / NaH / tetrahydrofuran; dimethylsulfoxide / 1 h / 0 - 5 °C
2: 4.32 g / formic acid; Na2S2O5 / ethanol / 0.5 h / Heating
View Scheme
101666-67-5, 127182-43-8

6-O-methyl-N-demethylerythromycin A 9-oxime

81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCOOH / ethanol / Heating
2: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2 / catalytic hydrogenation
2: HCOOH / ethanol / Heating
3: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran
2: H2 / catalytic hydrogenation
3: HCOOH / ethanol / Heating
4: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: CHCl3 / isomerization
2: 82 percent / NaH / dimethylformamide
3: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran
4: H2 / catalytic hydrogenation
5: HCOOH / ethanol / Heating
6: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 82 percent / NaH / dimethylformamide
2: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran
3: H2 / catalytic hydrogenation
4: HCOOH / ethanol / Heating
5: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
81103-09-5

2'-O,3'-N-bis(benzyloxycarbonyl)-N-demethylerythromycin A

81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NH2OH*HCl, AcONa / methanol
2: CHCl3 / isomerization
3: 82 percent / NaH / dimethylformamide
4: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran
5: H2 / catalytic hydrogenation
6: HCOOH / ethanol / Heating
7: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
Multi-step reaction with 6 steps
1: 75 percent / NH2OH*HCl, AcONa / methanol
2: 82 percent / NaH / dimethylformamide
3: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran
4: H2 / catalytic hydrogenation
5: HCOOH / ethanol / Heating
6: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
103450-87-9

3-O-descladinosyl-9-oxime clarithromycin

81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 0.78 g / ammonium acetate, 15percent aq. titanium(III) chloride / methanol / 6 h
2: H2O / methanol / 23 °C / pH 12.4 or pH 7
View Scheme
13127-18-9

(9-E)-deoxo-9-hydroximinoerythromycin A

74-88-4

methyl iodide

81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: (9-E)-deoxo-9-hydroximinoerythromycin A; methyl iodide With 2-Methoxypropene; Pyridine hydrobromide; potassium hexamethylsilazane In dichloromethane
Stage #2: With formic acid; sodium hydrogensulfite In ethanol; dichloromethane at 82 - 84℃;
791845-56-2

2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime

81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: 2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime With formic acid In ethanol; water at 40 - 45℃; for 3h; pH=2.5 - 3.5;
Stage #2: With sodium hydrogensulfite In ethanol; water for 1h; Product distribution / selectivity; Heating / reflux;
643726-97-0

clarithromycin acetate

81103-11-9

clarithromycin

Conditions
ConditionsYield
at 120℃; for 4h; under vacuum;

clarithromycin trifluoroacetate

81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 40℃; for 1h; pH=9 - 11; Product distribution / selectivity;

clarithromycin para-toluene sulphonate

81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 40℃; for 1h; pH=9 - 11; Product distribution / selectivity;

clarithromycin oxalate

81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 40℃; for 1h; pH=9 - 11; Product distribution / selectivity;
119699-81-9

2',4"-O-bis (trimethylsilyl)-6-O-methylerythromycin A 9-[O-(1-methoxy-1-methylethyl)oxime]

81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: 2',4"-O-bis (trimethylsilyl)-6-O-methylerythromycin A 9-[O-(1-methoxy-1-methylethyl)oxime] With formic acid; sodium hydrogensulfite In denatured spirit for 2h; Heating / reflux;
Stage #2: With sodium hydroxide In denatured spirit; water at 20℃; pH=10.5; Product distribution / selectivity;
119685-39-1

6-O-methyl-2',4-bis(trimethylsilyl)-erythromycin A 9-O-(2-methoxyprop-2-yl)oxime

81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: 6-O-methyl-2',4-bis(trimethylsilyl)-erythromycin A 9-O-(2-methoxyprop-2-yl)oxime With sodium metabisulfite; formic acid; water In ethanol at 25 - 63℃; for 10h; pH=3.8 - 4.1;
Stage #2: With sodium hydroxide In ethanol; water at 30 - 35℃; for 0.5h; pH=10.5 - 11.0; Product distribution / selectivity;
81103-11-9

clarithromycin

108-24-7

acetic anhydride

152235-55-7

2',4''-di-O-acetyl-6-O-methylerythromycin A

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃;100%
With dmap; triethylamine In dichloromethane at 20℃; for 17h;99%
With dmap In dichloromethane at 20℃; for 18h; Inert atmosphere;99%
81103-11-9

clarithromycin

108-24-7

acetic anhydride

103461-66-1

2'-O-acetyl-6-O-methylerythromycin A

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 48h;99%
With triethylamine at 20℃;95%
With triethylamine In dichloromethane at 20℃; for 12h;95%
81103-11-9

clarithromycin

118058-75-6

3'-N,N-didemethyl-6-O-methylerythromycin A

Conditions
ConditionsYield
With iodine; sodium acetate In methanol; water at 20℃; for 0.25h; UV-irradiation;99%
81103-11-9

clarithromycin

93-97-0

benzoic acid anhydride

484670-64-6

clarithromycin dibenzoate

Conditions
ConditionsYield
With 2-(dimethylamino)pyrimidine; triethylamine In N,N-dimethyl-formamide at 45℃; for 4h;98%
With dmap; triethylamine In ethyl acetate at 70℃; for 16h;97%
With dmap; triethylamine In dichloromethane55%
81103-11-9

clarithromycin

118058-74-5

3-O-descladinosylclarithromycin

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 0.5h;96%
Stage #1: clarithromycin With hydrogenchloride In methanol; water at 20℃;
Stage #2: With sodium hydroxide In methanol; water pH=10 - 11;
96%
With hydrogenchloride In water at 20℃; for 3h;96%
81103-11-9

clarithromycin

6-O-methyl-9-hydrazono erythromycin A

Conditions
ConditionsYield
With hydrazinium monoacetate In methanol for 46h; Reflux;95.1%
With hydrazinium monoacetate In methanol for 46h; Reflux;70%
81103-11-9

clarithromycin

106-96-7

propargyl bromide

C41H72NO13(1+)*Br(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;94%
81103-11-9

clarithromycin

C42H76NO13(1+)*Br(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;94%
81103-11-9

clarithromycin

4392-24-9

3-phenylprop-2-en-1-yl bromide

C47H78NO13(1+)*Br(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;93%
81103-11-9

clarithromycin

101666-68-6

N-desmethylclarithromycin

Conditions
ConditionsYield
Stage #1: clarithromycin With iodine; sodium acetate In methanol; water at 55 - 60℃; for 3h;
Stage #2: With ammonia In methanol; chloroform; water
92%
Stage #1: clarithromycin With iodine; sodium acetate In methanol; water at 55 - 60℃; for 3h;
Stage #2: With ammonia In methanol; chloroform; water
92%
With iodine; sodium acetate In methanol; water at 55 - 60℃; for 3h;92%
81103-11-9

clarithromycin

118074-07-0

6-O-methylerythromycin A N-oxide

Conditions
ConditionsYield
With dihydrogen peroxide In methanol; water at 20℃; for 15h;92%
2035-75-8

adipic anhydride

81103-11-9

clarithromycin

C44H77NO16

Conditions
ConditionsYield
With dmap In chloroform at 110℃; for 8h; Temperature;91%
81103-11-9

clarithromycin

870-63-3

prenyl bromide

C43H78NO13(1+)*Br(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;91%
81103-11-9

clarithromycin

103450-87-9

3-O-descladinosyl-9-oxime clarithromycin

Conditions
ConditionsYield
Stage #1: clarithromycin With hydroxylamine hydrochloride; sodium acetate In methanol at 75℃; for 12h;
Stage #2: With hydrogenchloride In methanol; water at 75℃; for 5h;
90%
With hydroxylamine hydrochloride; triethylamine In methanol for 24h; Heating;2.2 g
Stage #1: clarithromycin With hydroxylamine hydrochloride; sodium carbonate In methanol at 20 - 65℃; for 12 - 24h;
Stage #2: With sodium hydroxide In methanol; dichloromethane; water pH=9 - 12;
81103-11-9

clarithromycin

127253-06-9

6-methoxyerythromycin A 9-oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate at 80℃;90%
With hydroxylamine; acetic acid In water; isopropyl alcohol at 40℃; for 120h; Inert atmosphere;64%
34846-44-1

3-Bromomethylthiophene

81103-11-9

clarithromycin

C43H74NO13S(1+)*Br(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;89%
81103-11-9

clarithromycin

106-95-6

allyl bromide

Br(1-)*C41H74NO13(1+)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;88%
In N,N-dimethyl-formamide at 20℃; for 1.25h;
75-44-5

phosgene

81103-11-9

clarithromycin

107-18-6

allyl alcohol

898833-50-6

4''-O-(allyloxycarbonyl)-N-demethylclarithromycin 2',3'-carbamate-11,12-carbonate

Conditions
ConditionsYield
Stage #1: phosgene; clarithromycin With pyridine In dichloromethane; toluene at 20℃; for 5h;
Stage #2: allyl alcohol In dichloromethane; toluene at 20℃; for 0.5h; Further stages.;
87%
75-77-4

chloro-trimethyl-silane

81103-11-9

clarithromycin

130073-49-3

6-O-Methyl-2',4''-O-bis(trimethylsilyl)erythromycin A

Conditions
ConditionsYield
With 1-(Trimethylsilyl)imidazole In dichloromethane for 0.5h; Ambient temperature;80%
994-30-9

triethylsilyl chloride

81103-11-9

clarithromycin

1009561-37-8

2',4''-di-TES-6-O-methyl-erythromycin A

Conditions
ConditionsYield
With dmap; triethylamine In acetonitrile at 0 - 30℃; Inert atmosphere;80%
81103-11-9

clarithromycin

208456-82-0

3-hydroxy-6-O-methyl-10,11-anhydroerythromycin A

Conditions
ConditionsYield
Stage #1: clarithromycin With [1,3]-dioxolan-2-one; triethylamine for 44h; Heating / reflux;
Stage #2: With hydrogenchloride In ethanol; water at 20℃; for 24h;
Stage #3: With potassium hydroxide In ethanol; water pH=10 - 11;
74%
Multi-step reaction with 5 steps
1: hydrogenchloride / water / 2 h / 20 °C
2: dichloromethane / 1 h / 20 °C
3: pyridine / dichloromethane / 9 h / -5 °C
4: potassium tert-butylate; allyl bromide / tetrahydrofuran; dimethyl sulfoxide / 0.5 h / 0 °C
5: methanol / Reflux
View Scheme
81103-11-9

clarithromycin

C38H62(2)H7NO13

Conditions
ConditionsYield
With water-d2; lithium carbonate; triisopropylsilanethiol In 1-methyl-pyrrolidin-2-one at 20℃; Irradiation;70%

2-(aminooxy)acetic acid hemihydrochloride

81103-11-9

clarithromycin

9-(O-carboxymethyloxime)clarithromycin

Conditions
ConditionsYield
In methanol at 30 - 35℃; for 48h;60%
81103-11-9

clarithromycin

622-78-6

Benzyl isothiocyanate

2'-O,3'-N-(N-benzylcarbonimidoyl)-3'-N-demethyl-6-O-methylerythromycin A

Conditions
ConditionsYield
With iodine; sodium hydrogencarbonate; 2-amino-2-hydroxymethyl-1,3-propanediol In acetonitrile for 2h; Irradiation;56%
81103-11-9

clarithromycin

9-dihydro-6-O-methylerythromycin A

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran; methanol at 0 - 20℃; for 25h; Inert atmosphere;52%
81103-11-9

clarithromycin

124-63-0

methanesulfonyl chloride

129318-85-0

2',4''-di-O-methanesulfonyl-6-O-methylerythromycin A

Conditions
ConditionsYield
With triethylamine In acetone 1.) 0 to 3 deg C, 30 min, 2.) RT, 2 h;41.7%
Downstream Products
160145-83-5
191114-48-4
  • Clarithromycin

  • Casno:

    81103-11-9

    Clarithromycin

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    Time Efficiency, Cost Effectiveness, Better Possibilities! 1. Better Quality & Competetive Price. 2. Quick & Professional Quotation. 3. Over Three Decades of Experience in This Field. 4. Quick & Safe &am

    Sunmore Healthcare Co., LTD., is a professional solution provider to the Pharmaceutical and Healthcare Industry, headquartered in Central of China, catering to the raw materials ne

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    Tel:18273476892

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  • Clarithromycin    manufacturer/supplier

  • Casno:

    81103-11-9

    Clarithromycin manufacturer/supplier

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

    Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd (JL Pharm) is established in 2012 at the beautiful West Lake – Hangzhou city, China. The company's main business includes R&D, Produ

  •  Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

     China (Mainland)  |  Contact Details

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  • Clarithromycin 81103-11-9

  • Casno:

    81103-11-9

    MSDS/COA Download

    Clarithromycin 81103-11-9

    Min.Order: 1 Kilogram

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    hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

    Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of

  •  Hebei yanxi chemical co.,LTD.

     China (Mainland)  |  Contact Details

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    Tel:86-0311-66561638

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  • Clarithromycin

  • Casno:

    81103-11-9

    Clarithromycin

    Min.Order: 1 Gram

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  • Factory supply clarithromycin powder with best price

  • Casno:

    81103-11-9

    Factory supply clarithromycin powder with best price

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Specification

1. Introduction of Clarithromycin
Clarithromycin is one kind of white or almost white crystalline powder or colourless crystalline needles. The Systematic (IUPAC) name of this chemical is (3R,4S,5S,6R,7R,9R,11S,12R,13S,14S)-6-{[(2S,3R,4S,6R) -4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy} -14-ethyl-12,13-dihydroxy-4-{[(2R,4S,5S,6S)-5-hydroxy -4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7 -methoxy-3,5,7,9,11,13-hexamethyl -1-oxacyclotetradecane-2,10-dione. The Classification Code of it is Anti-Bacterial Agents; Anti-Infective Agents; Antibacterial; Drug / Therapeutic Agent; Enzyme Inhibitors; Human Data; Protein synthesis inhibitors.

Clarithromycin belongs to Antibiotics;APIs;Antibiotics for Research and Experimental Use;Biochemistry;Macrolides (Antibiotics for Research and Experimental Use);Intermediates & Fine Chemicals;Pharmaceuticals;API's;1694 Pharmaceuticals&Personal Care Products;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;MacrolidesEPA;Neats;Spectrum of Activity. Besides, it should stored in -20°C Freezer.

2. Properties of Clarithromycin
Physical properties about Clarithromycin are:

(1)Index of Refraction: 1.526; (2)Molar Refractivity: 194 cm3; (3)Molar Volume: 631.9 cm3; (4)Density: 1.18 g/cm3; (5)Solubility: Insoluble; (6)Flash Point: 440.9 °C; (7)Melting Point: 217-220 °C; (8)Surface Tension: 48.7 dyne/cm; (9)Enthalpy of Vaporization: 133.36 kJ/mol; (10)Vapour Pressure: 5.06E-30 mmHg at 25 °C; (11)Boiling Point of 6-o-Methoxyerythromycin: 805.5 °C at 760 mmHg.

3. Structure Descriptors of Clarithromycin
(1)Canonical SMILES: CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC
(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O
(2)Isomeric SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O
(3)InChI: InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
(4)InChIKey: AGOYDEPGAOXOCK-KCBOHYOISA-N

4. Toxicity of Clarithromycin

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 5gm/kg (5000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: HEMORRHAGE
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 1453, 1988.
mouse LD50 intraperitoneal 850mg/kg (850mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Chemotherapy Vol. 36(Suppl,
mouse LD50 intravenous 173mg/kg (173mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.
mouse LD50 oral 1230mg/kg (1230mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 1433, 1988.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE Chemotherapy Vol. 36(Suppl,
rat LD50 intraperitoneal 669mg/kg (669mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Chemotherapy Vol. 36(Suppl,
rat LD50 oral 1270mg/kg (1270mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 1433, 1988.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE Chemotherapy Vol. 36(Suppl,
women TDLo oral 30mg/kg/3D-I (30mg/kg) CARDIAC: CHANGE IN RATE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Annals of Emergency Medicine. Vol. 30, Pg. 542, 1997.

5. Physical Properties of Clarithromycin

Physical Property Value Units Temp (deg C) Source
Melting Point 220 dec deg C   EXP
pKa Dissociation Constant 8.99 (none) 25 EXP
log P (octanol-water) 3.16 (none)   EXP
Water Solubility 0.342 mg/L 25 EST
Vapor Pressure 8.60E-27 mm Hg 25 EST
Henry's Law Constant 1.73E-29 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.78E-10 cm3/molecule-sec 25 EST

6. Safety information of Clarithromycin
A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Human systemic effects. When heated to decomposition it emits toxic vapors of NOx.
Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RTECS: KF4997000

The first aid is as following. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water, and get medical aid immediately. In addition, it should be stored only in original container, or keep its container tightly closed.

7. Uses of Clarithromycin
The usage of Clarithromycin (CAS NO.81103-11-9) is a semi-synthetic macrolide antibiotic, a derivative of erythromycin. And it is a macrolide antibiotic used to treat upper and lower respiratory tract infections, skin and soft tissue infections. Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia, skin and skin structure infections. In addition, it is sometimes used to treat legionellosis, Helicobacter pylori, and lyme disease.

8. Production of Clarithromycin
(1)Use Erythromycin as the raw material and get the methyl off amino by using hydrolysis.
(2)Then get it reaction with Benzyl chloroformate and protect 5-tetrahydropyran ring side-chain hydroxyl and amino.
(3)In the methyl iodide reaction of dimethyl sulfoxide and tetrahydrofuran, carry out six on the methylation of hydroxyl and deprotected by catalytic hydrogenolysis,then reaction with the amino-formaldehyde.
(4)Finally,it is reduced to methyl, named clarithromycin.

The detailed steps are as follows:

Production of Clarithromycin