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| CAS No.: | 82-92-8 |
|---|---|
| Name: | CYCLIZINE HCL |
| Article Data: | 10 |
| Molecular Structure: | |
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| Formula: | C18H22 N2 |
| Molecular Weight: | 266.386 |
| Synonyms: | (N-Benzhydryl)(N'-methyl)diethylenediamine;1-Diphenylmethyl-4-methylpiperazine; Compound 47-83; Cyclizine; Marezine; N-Benzhydryl-N'-methylpiperazine;N-Methyl-N'-benzhydrylpiperazine; NSC 26608; Nautazine; Ne-Devomit;Neo-Devomit; Wellcome prepn. 47-83 |
| Density: | 0.9934 (rough estimate) |
| Melting Point: | 105.5-107.5° |
| Boiling Point: | 399.58°C (rough estimate) |
| Safety: | Poison by ingestion. Human systemic effects: unspecified blood effects. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 6.48000 |
| LogP: | 2.89920 |
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Chemistry
Chemical Name: Cyclizine Hcl
IUPAC NAME: 1-Benzhydryl-4-methylpiperazine
CAS No.: 82-92-8
EINECS: 201-445-5
Molecular Formula: C18H23ClN2
Molecular Weight: 302.84 g/mol
Density: 1.062 g/cm3
Flash Point: 159.1 °C
Boiling Point: 363.7 °C at 760 mmHg
Following is the structure of Emoquil (82-92-8):
Product Categories about Emoquil (82-92-8) is Miscellaneous
The chemical synonymous of Emoquil (82-92-8) are (N-Benzhydryl)(N’-methyl)diethylenediamine ; (N-Benzhydryl)(N'-methyl)diethylenediamine ; 1-(Diphenylmethyl)-4-methyl-piperazin ; 1-Benzhydryl-4-methylpiperazine ; 1-Diphenylmethyl-4-methylpiperazine
Toxicity Data With Reference
| 1. | orl-wmn TDLo:126 mg/kg/6W-I:BLD | BMJOAE British Medical Journal. 292 (1986),174. | ||
| 2. | orl-mus LD50:147 mg/kg | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,218. |
Safety Profile
Poison by ingestion. Human systemic effects: unspecified blood effects. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Specification
Emoquil (82-92-8) is an antihistamine drug used to treat nausea, vomiting and dizziness associated with motion sickness, vertigo and post-operatively following administration of general anaesthesia and opioids. It is abused as an opiate/opioid-enhancing antihistamine booster and separately for its anticholinergic effects.It is a piperazine derivative with histamine H1-receptor antagonist (antihistamine) activity. The precise mechanism of action in inhibiting the symptoms of motion sickness is not well understood. It may have effects directly on the labyrinthine apparatus and on the chemoreceptor trigger zone. Cyclizine exerts a central anticholinergic (antimuscarinic) action.Its antimuscarinic action warrants caution in patients with prostatic hypertrophy, urinary retention, or glaucoma. Liver disease exacerbates its sedative effects. It cannot be combined with diclofenac, for example in the same syringe or bag of fluids, as a crystallisation reaction occurs. Its main off-label use is as an opioid/opiate potentiator, commonly preferred highly to other anti-histamines (most commonly used as opioid boosters: tripelennamine, hydroxyzine, meclizine, doxylamine, diphenhydramine, etc.). The drug Diconal is the opioid Dipipanone and Cyclizine combined for IV use (discontinued in the U.S. for its high abuse potential). Dipipanone's closest relative is methadone. Those using methadone recreationally combine cyclizine with their methadone dose, a combination that is known to produce strong psychoactive effects. It is also sold in combination with another opioid dipipanone under the brand name Diconal.Intravenous cyclizine produces the strongest effects, although it can also be taken orally to achieve a more euphoric high.