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| CAS No.: | 86-88-4 |
|---|---|
| Name: | 1-(1-NAPHTHYL)-2-THIOUREA |
| Article Data: | 34 |
| Molecular Structure: | |
|
|
|
| Formula: | C11H10 N2 S |
| Molecular Weight: | 202.28 |
| Synonyms: | Thiourea,1-naphthalenyl- (9CI); Urea, 1-(1-naphthyl)-2-thio- (7CI,8CI);1-(1-Naphthyl)-2-thiourea; 1-(1-Naphthyl)thiourea; 1-Naphthylthiourea; ANTU;Alrato; Anturat; Bantu; Chemical 109; Dirax; Kripid; Krysid;N-1-Naphthylthiourea; NSC 3287; Naphtox; Rattrack; Smeesana; U 5227; a-Naphthylthiocarbamide; a-Naphthylthiourea |
| EINECS: | 201-706-3 |
| Density: | 1.333 g/cm3 |
| Melting Point: | 193 °C |
| Boiling Point: | 377.6 °C at 760 mmHg |
| Flash Point: | 182.1 °C |
| Solubility: |
Stability
Toxicology
|
| Appearance: | WHITE, ODOURLESS CRYSTALLINE POWDER |
| Hazard Symbols: | TLV: 0.3 mg/m3. |
| Risk Codes: | 28-40 |
| Safety: | Poison by ingestion and intraperitoneal routes. Moderately toxic to humans by an unspecified route. Questionable carcinogen with experimental tumorigenic data. Mutagenic data. A rodenticide used extensively. Death is caused by pulmonary edema. Chronic toxicity has been known to cause dermatitis and a decrease in the white blood cells. When heated to decomposition it emits toxic fumes of NOx and SOx. |
| PSA: | 70.14000 |
| LogP: | 3.26860 |
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Chemistry
Molecular Structure:
Molecular Formula: C11H10N2S
Molecular Weight: 202.2755
IUPAC Name: Naphthalen-1-ylthiourea
Synonyms of ANTU (CAS NO.86-88-4): 1-(1-Naphthyl)-2-thiourea ; Thiourea, 1-naphthalenyl- ; Thiourea, N-1-naphthalenyl- ; Urea, 1-(1-naphthyl)-2-thio- ; 1-Naphthylthiourea ; Naphthylthiourea ; Naphthylthiourea [UN1651] [Poison] ; RCRA waste no. P072 ; UN1651 ; alpha-Naphthylthiourea
CAS NO: 86-88-4
Classification Code: Agricultural Chemical ; Human Data ; Mutation data ; Pesticides ; Rodenticide ; Rodenticides ; Tumor data
Melting point: 193 °C
Index of Refraction: 1.794
Molar Refractivity: 64.52 cm3
Molar Volume: 151.6 cm3
Surface Tension: 74.4 dyne/cm
Density: 1.333 g/cm3
Flash Point: 182.1 °C
Enthalpy of Vaporization: 62.53 kJ/mol
Boiling Point: 377.6 °C at 760 mmHg
Vapour Pressure: 6.69E-06 mmHg at 25°C
Uses
ANTU (CAS NO.86-88-4) is used as a rodenticide.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | oral | 500mg/kg (500mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 22, 1946. | |
| chicken | LD50 | intraperitoneal | 2500mg/kg (2500mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 22, 1946. | |
| chicken | LD50 | oral | 4250mg/kg (4250mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 22, 1946. | |
| chicken | LD50 | unreported | 700mg/kg (700mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 238, 1971. | |
| dog | LD50 | intraperitoneal | 16mg/kg (16mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 22, 1946. | |
| dog | LD50 | oral | 380ug/kg (0.38mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 57, 1966. | |
| guinea pig | LD50 | intraperitoneal | 350mg/kg (350mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 22, 1946. | |
| man | LDLo | unreported | 588mg/kg (588mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
| monkey | LD50 | intraperitoneal | 175mg/kg (175mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 22, 1946. | |
| monkey | LD50 | oral | 4250mg/kg (4250mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
| monkey | LD50 | unreported | > 2gm/kg (2000mg/kg) | Bollettino Chimico Farmaceutico. Vol. 97, Pg. 289, 1958. | |
| mouse | LD50 | intraperitoneal | 10mg/kg (10mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| mouse | LD50 | oral | 5mg/kg (5mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977. | |
| pig | LDLo | oral | 50mg/kg (50mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977. | |
| rabbit | LD50 | unreported | > 200mg/kg (200mg/kg) | Bollettino Chimico Farmaceutico. Vol. 97, Pg. 289, 1958. | |
| rat | LD50 | intraperitoneal | 2470ug/kg (2.47mg/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: PLEURAL EFFUSION | Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 432, 1949. |
| rat | LD50 | oral | 6mg/kg (6mg/kg) | Quarterly Bulletin--Association of Food and Drug Officials of the United States. Vol. 16, Pg. 47, 1952. |
Consensus Reports
IARC Cancer Review: Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 30 (1983),p. 347.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List. EPA Genetic Toxicology Program.
Safety Profile
Hazard Codes of ANTU (CAS NO.86-88-4): 
T+
RIDADR: 1651
RTECS: YT9275000
HazardClass: 6.1
PackingGroup: I
Poison by ingestion and intraperitoneal routes. Moderately toxic to humans by an unspecified route. Questionable carcinogen with experimental tumorigenic data. Mutagenic data. A rodenticide used extensively. Death is caused by pulmonary edema. Chronic toxicity has been known to cause dermatitis and a decrease in the white blood cells. When heated to decomposition it emits toxic fumes of NOx and SOx.
Standards and Recommendations
OSHA PEL: TWA 0.3 mg/m3
ACGIH TLV: TWA 0.3 mg/m3; Not Classifiable as a Human Carcinogen
DFG MAK: 0.3 mg/m3
DOT Classification: 6.1; Label: Poison