Products Categories
CAS No.: | 863329-66-2 |
---|---|
Name: | 2'-deoxy-2'-fluoro-2'-C-methyluridine |
Article Data: | 26 |
Molecular Structure: | |
Formula: | C10H13FN2O5 |
Molecular Weight: | 260.222 |
Synonyms: | URI002; Ro-2433; PSI6206; PSI-6206; 2'-deoxy-2'-fluoro-2'-C-methyl-uridine; |
EINECS: | 810-481-6 |
Density: | 1.55 |
Melting Point: | 237-238℃ |
Appearance: | Off-white solid |
PSA: | 104.55000 |
LogP: | -1.48460 |
2'-deoxy-2'-fluoro-2'-methyluridine
Conditions | Yield |
---|---|
With ammonia In methanol at 20℃; | 100% |
With ammonia In methanol at 20℃; for 17h; | 93% |
Stage #1: (2‘R)-2‘-deoxy-2’-fluoro-2-methyluridine-3’,5’-dibenzoate With N-butylamine at 45 - 50℃; Stage #2: With methanol In tert-butyl methyl ether at 60 - 70℃; | 90.7% |
2'-deoxy-2'-fluoro-2'-methyluridine
Conditions | Yield |
---|---|
With tetramethylammonium fluoride; acetic acid In N,N-dimethyl-formamide at 20℃; for 2h; Time; Inert atmosphere; | 95% |
2'-deoxy-2'-fluoro-2'-methyluridine
Conditions | Yield |
---|---|
With ammonia In methanol at 0 - 15℃; for 27h; | 94% |
2'-deoxy-2'-fluoro-2'-methyluridine
Conditions | Yield |
---|---|
With ammonia In methanol at 5 - 25℃; for 26h; | 92.5% |
C24H20N2O7
2'-deoxy-2'-fluoro-2'-methyluridine
Conditions | Yield |
---|---|
With potassium fluoride; 2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecin In N,N-dimethyl-formamide; toluene for 5h; Reflux; | 92.3% |
2'-deoxy-2'-fluoro-2'-methyluridine
Conditions | Yield |
---|---|
With manganese(IV) oxide In toluene at 20℃; for 2h; | 91% |
N-(1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
2'-deoxy-2'-fluoro-2'-methyluridine
Conditions | Yield |
---|---|
With sodium hypochlorite; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran at 0 - 30℃; for 24h; | 85% |
1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyl-9-methylenetetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-pyrimidine-2,4(1H,3H)-dione
2'-deoxy-2'-fluoro-2'-methyluridine
Conditions | Yield |
---|---|
With potassium hydrogensulfate; hydrogen fluoride In 1,2-dichloro-ethane at 0℃; for 2h; | 82% |
Conditions | Yield |
---|---|
Stage #1: uracil With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane In chlorobenzene Reflux; Stage #2: C19H39FO5Si2 With tin(IV) chloride In chlorobenzene at 50℃; Stage #3: With tetrabutyl ammonium fluoride In tetrahydrofuran at 55 - 60℃; Reagent/catalyst; Solvent; | 72% |
(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
2'-deoxy-2'-fluoro-2'-methyluridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 87 percent / aq. HOAc / 12 h / Heating 2: 100 percent / NH3 / methanol / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetic acid / water / 5 h / 110 °C 2: ammonia; methanol / 30 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetic acid / water / 90 - 105 °C 2: sodium methylate / methanol / Reflux View Scheme |