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876717-53-2

Basic Information
CAS No.: 876717-53-2
Name: 2-METHYLAMINO-ISONICOTINIC ACID
Molecular Structure:
Molecular Structure of 876717-53-2 (2-METHYLAMINO-ISONICOTINIC ACID)
Formula: 2-METHYLAMINO-ISONICOTINIC ACID
Molecular Weight: 152.153
Synonyms: ASINEX-REAG BAS 10153999;
Density: 1.327g/cm3
Boiling Point: 454.2°C at 760 mmHg
Flash Point: 228.5°C
Hazard Symbols: Xi
PSA: 62.22000
LogP: 0.89450
Synthetic route
876717-53-2

2-(methylamino)isonicotinic acid

1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-aminium chloride

1622458-36-9

N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2-(methylamino)isonicotinamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere;56%
876717-53-2

2-(methylamino)isonicotinic acid

4-amino-5-((1-aminocyclopentyl)methoxy)-1H-benzo[c][1,2,6]thiadiazine 2,2-dioxide hydrochloride

1622458-41-6

N-(1-(((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)methyl)cyclopentyl)-2-(methylamino)isonicotinamide

Conditions
ConditionsYield
Stage #1: 4-amino-5-((1-aminocyclopentyl)methoxy)-1H-benzo[c][1,2,6]thiadiazine 2,2-dioxide hydrochloride With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: 2-(methylamino)isonicotinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20 - 55℃;
34%
55989-13-4

(RS)-3-(4-chlorophenyl)piperidine

876717-53-2

2-(methylamino)isonicotinic acid

4-{[3-(4-chlorophenyl)piperidin-1-yl]carbonyl}-N-methylpyridin-2-amine

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In dichloromethane; ethyl acetate at 20 - 25℃; for 18h;33%
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