CAS No.897-15-4,DOTHIEPIN HCL Suppliers

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Basic Information

Molecular Structure:
CAS No.:	897-15-4
Name:	DOTHIEPIN HCL
Article Data:	1

Formula:	C19H21 N S . Cl H
Molecular Weight:	331.909
Synonyms:	1-Propanamine,3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-, hydrochloride (9CI);Dibenzo[b,e]thiepin-D11(6H),g-propylamine,N,N-dimethyl-, hydrochloride (7CI,8CI); Dibenzo[b,e]thiepin, 1-propanaminederiv.; 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]thiepinhydrochloride; Altapin; Depresym; Dosulepin chloride; Dosulepin hydrochloride;Dothiepin hydrochloride; Prothiaden hydrochloride
EINECS:	212-978-8
Melting Point:	218-221ºC
Boiling Point:	430.9 °C at 760 mmHg
Flash Point:	214.4 °C
Appearance:	Crystalline powder
Hazard Symbols:	F,T,Xn
Risk Codes:	R22 R36 R43 S25 S37/39 S45
Safety:	Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Human systemic effects by ingestion: cardiomyopathy. Experimental teratogenic and reproductive effects. An antidepressant. When heated to decomposition it emits very toxic fumes of NO_x, SO_x and HCl.
PSA:	28.54000
LogP:	5.47770

Synthetic route

: 113-53-1, 25627-37-6, 25627-38-7
dothiepin

: 897-15-4
dosulepin hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; ethanol

: 541-41-3
chloroformic acid ethyl ester

: 897-15-4
dosulepin hydrochloride

: 2025-60-7
11-<3-(Methyl-ethoxycarbonylamino)-propyliden>-6,11-dihydro-dibenzothiepin

Conditions

Conditions	Yield
With sodium hydrogencarbonate In toluene for 6h; Heating;	92%

: 897-15-4
dosulepin hydrochloride

: 1154-09-2
N-methyldibenzothiepin-Δ11(6H),γ-propylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 92 percent / 1.) NaHCO3 / toluene / 6 h / Heating 2: 77 percent / KOH / butan-1-ol / 4 h / Heating View Scheme

: 897-15-4
dosulepin hydrochloride

: 3-thiepin-11-ylidene)propyl>-N-methylamino>propionic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 92 percent / 1.) NaHCO3 / toluene / 6 h / Heating 2: 77 percent / KOH / butan-1-ol / 4 h / Heating 3: ethanol / 2 h / Heating 4: NaOH / methanol / 0.5 h / Heating View Scheme

: 897-15-4
dosulepin hydrochloride

: 3-(Methyl-{3-[11H-10-thia-dibenzo[a,d]cyclohepten-(5Z)-ylidene]-propyl}-amino)-propionic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 92 percent / 1.) NaHCO3 / toluene / 6 h / Heating 2: 77 percent / KOH / butan-1-ol / 4 h / Heating 3: ethanol / 2 h / Heating 4: NaOH / methanol / 0.5 h / Heating View Scheme

: 897-15-4
dosulepin hydrochloride

: ethyl 3-thiepin-11-ylidene)propyl>-N-methylamino>propionate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 92 percent / 1.) NaHCO3 / toluene / 6 h / Heating 2: 77 percent / KOH / butan-1-ol / 4 h / Heating 3: ethanol / 2 h / Heating View Scheme

: 897-15-4
dosulepin hydrochloride

: 3-(Methyl-{3-[11H-10-thia-dibenzo[a,d]cyclohepten-(5Z)-ylidene]-propyl}-amino)-propionic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 92 percent / 1.) NaHCO3 / toluene / 6 h / Heating 2: 77 percent / KOH / butan-1-ol / 4 h / Heating 3: ethanol / 2 h / Heating View Scheme

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Chemistry

Chemical Name: Dothiepin HCL
IUPAC NAME: (3Z)-3-(6H-benzo[c][1]benzothiepin-11-ylidene)-N,N-dimethylpropan-1-amine hydrochloride ; 3E)-3-(6H-benzo[c][1]benzothiepin-11-ylidene)-N,N-dimethylpropan-1-amine hydrochloride ; (3Z)-3-(6H-benzo[c][1]benzothiepin-11-ylidene)-N,N-dimethylpropan-1-amine
CAS No.: 897-15-4
EINECS: 212-978-8
Molecular Formula: C₁₉H₂₂ClNS
Molecular Weight: 331.9 g/mol
Flash Point: 214.4 °C
Boiling Point: 430.9 °C at 760 mmHg
Following is the structure of 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine hydrochloride (CAS No.897-15-4):

Product Categories about 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine hydrochloride (CAS No.897-15-4) is Antidepressant
The chemical synonymous of 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine hydrochloride (CAS No.897-15-4) are Dothiepin Hcl ; Dothiepin Hydrochloride ; Dosulepin Hcl ; 11-(3-Dimethylaminopropylidene)-6,11-Dihydrodibenzo(B,E)Thiepinehydrochlorid ; 3-Dibenzo(B,E)Thiepin-11(6h)-Ylidene-N,N-Dimethyl-1-Propanaminhydrochlor ; Dosulepinchloride ; Dosulepinhydrochloride ; N,N-Dimethyldibenzo(B,E)Thiepin-Delta(Sup11(6h),Gamma)-Propylaminehydrochlo

Toxicity Data With Reference

1.	orl-rat TDLo:440 mg/kg (MGN):REP	OYYAA2 Oyo Yakuri. Pharmacometrics. 27 (1984),1103.
2.	orl-wmn LDLo:40 mg/kg	PGMJAO Postgraduate Medical Journal. 60 (1984),442.
3.	orl-cld TDLo:90 mg/kg:CVS	PGMJAO Postgraduate Medical Journal. 60 (1984),442.
4.	orl-rat LD50:260 mg/kg	27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
5.	ipr-rat LD50:105 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 14 (1983),192.
6.	scu-rat LD50:760 mg/kg	27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
7.	ivn-rat LD50:24 mg/kg	27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
8.	orl-mus LD50:209 mg/kg	27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
9.	ipr-mus LD50:116 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 14 (1983),192.

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Human systemic effects by ingestion: cardiomyopathy. Experimental teratogenic and reproductive effects. An antidepressant. When heated to decomposition it emits very toxic fumes of NO_x, SO_x and HCl.