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| CAS No.: | 9000-55-9 |
|---|---|
| Name: | PODOPHYLLUM RESIN |
| Molecular Structure: | |
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| Formula: | C88H92O34 |
| Molecular Weight: | 1693.65168 |
| Synonyms: | Podophyllin;Podophyllum (resin); Podophyllum (the resin); Podophyllum, resin; Podophyllum,resins of; Mayapple, resin; Resins Podophyllum |
| EINECS: | 232-546-2 |
| Density: | g/cm3 |
| Boiling Point: | °Cat760mmHg |
| Flash Point: | °C |
| Solubility: | Toxicity data (The meaning of "> negligible
Stability
Toxicology
Toxicity data |
| Appearance: | light yellow to brown powder |
| Hazard Symbols: |
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| Risk Codes: | 61-26/27/28-34 |
| Safety: | Poison by ingestion, subcutaneous, and intraperitoneal routes. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. An experimental teratogen. Other experimental reproductive effects. Combustible when exposed to heat or flames. When heated to decomposition it emits acrid smoke and irritating fumes. |
| PSA: | 433.18000 |
| LogP: | 8.67700 |
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Chemistry
Chemistry informtion about Podophyllum Resin (CAS NO.9000-55-9) is:
IUPAC Name: 8-Hydroxy-7-(Hydroxymethyl)-5-(3,4,5-Trimethoxyphenyl)-5,6,7,8-Tetrahydrobenzo[F][1,3]Benzodioxole-6-Carboxylic Acid; 5-Hydroxy-9-(3,4,5-Trimethoxyphenyl)-5a,6,8a,9-Tetrahydro-5h-[2]Benzofuro[5,6-F][1,3]Benzodioxol-8-One
Synonyms: Podophylium Resin ; Podophyllum Resin ; Podophyllin ; Podophyllin Ex Podophyllum Hexanndrum ; Podophyllin Ex Podophyllum Peltatum ; Podofillina ; Podophyllinfrompodophyllumpeltatum ; Podophyllum
MF: C88H92O34
MW: 1693.651680 g/mol
Storage temp.: 2-8°C
Form: powder
Color: brown
Stability: Stable. Incompatible with strong oxidizing agents.
Following is the molecular structure of Podophyllum Resin (CAS NO.9000-55-9) is:
Uses
Podophyllum Resin (CAS NO.9000-55-9) topical is used to treat genital warts on the outside of the penis or vagina, or on the skin between the rectum and the genitals. It may also be used for other purposes not listed in this medication guide.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | unreported | 120mg/kg (120mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
| man | LDLo | oral | 157mg/kg (157mg/kg) | behavioral: somnolence (general depressed activity) gastrointestinal: "hypermotility, diarrhea" gastrointestinal: nausea or vomiting | Southern Medical Journal. Vol. 75, Pg. 1269, 1982. |
| man | TDLo | oral | 1333mg/kg (1333mg/kg) | behavioral: coma | Human Toxicology. Vol. 1, Pg. 373, 1982. |
| mouse | LD50 | oral | 68mg/kg (68mg/kg) | behavioral: excitement behavioral: muscle weakness lungs, thorax, or respiration: dyspnea | Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951. |
| mouse | LD50 | subcutaneous | 58mg/kg (58mg/kg) | behavioral: excitement lungs, thorax, or respiration: dyspnea behavioral: muscle weakness | Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951. |
| rat | LD50 | intraperitoneal | 15mg/kg (15mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 113, Pg. 124, 1963. | |
| rat | LD50 | parenteral | 25mg/kg (25mg/kg) | peripheral nerve and sensation: flaccid paralysis without anesthesia (usually neuromuscular blockage) behavioral: muscle contraction or spasticity) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 84, Pg. 68, 1950. |
| rat | LD50 | subcutaneous | 18mg/kg (18mg/kg) | behavioral: excitement behavioral: muscle weakness lungs, thorax, or respiration: dyspnea | Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951. |
| women | LDLo | oral | 6mg/kg (6mg/kg) | behavioral: ataxia lungs, thorax, or respiration: respiratory stimulation gastrointestinal: nausea or vomiting | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 482, 1969. |
| women | TDLo | oral | 80mg/kg (80mg/kg) | sense organs and special senses: conjunctive irritation: eye vascular: bp lowering not characterized in autonomic section | Clinical Toxicology. Vol. 18, Pg. 973, 1981. |
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. An experimental teratogen. Other experimental reproductive effects. Combustible when exposed to heat or flames. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:
T+
Risk Statements:
R61:May cause harm to the unborn child.
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
R34:Causes burns.
Safety Statements:
S53:Avoid exposure - obtain special instructions before use.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: TP8925000
Specification
Podophyllum Resin (CAS NO.9000-55-9) is a light yellow to brown powder. It topical is a skin medication made from a powdered mixture of extracts from a plant called Mandrake, or May apple.