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| CAS No.: | 9001-13-2 |
|---|---|
| Name: | Hemocoagulase |
| Molecular Structure: | |
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| Formula: | N/A |
| Molecular Weight: | 0 |
| Synonyms: | Hemocoagulase;Peptocoagulase; Plasma coagulase; Plasmocoagulase; Reptilase S;Staphylocoagulase; Staphylococcal coagulase; Thrombin coagulase |
| EINECS: | 232-583-4 |
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Chemistry
Product Name: Coagulase (CAS NO.9001-13-2)
Mol File: 9001-13-2.mol
Einecs: 232-583-4
Uses
Coagulase (CAS NO.9001-13-2) is an enzyme produced by Staphylococcus aureus that converts fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Coagulase negativity excludes S. aureus. (That is to say, S. aureus is coagulase-positive.)
It is also produced by Yersinia pestis.
Coagulase reacts with prothrombin in the blood. The resulting complex is called staphylothrombin, which causes blood to clot by converting fibrinogen to fibrin. Coagulase is tightly bound to the surface of the bacteria S. aureus and can coat its surface with fibrin upon contact with blood. It has been proposed that fibrin-coated staphylococci resist phagocytosis making the bacteria more virulent. Bound coagulase is part of the larger family of MSCRAMMS.
Toxicity Data With Reference
| 1. | ivn-rat LD50:16,0200 units/kg | KSRNAM Kiso to Rinsho. Clinical Report. 9 (1975),2304. | ||
| 2. | scu-mus LD50:107 g/kg | TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 15 (1968),383. | ||
| 3. | ivn-mus LD50:53,700 mg/kg | TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 15 (1968),383. |
Safety Profile
An experimental teratogen. Other experimental reproductive effects.
Specification
Coagulase ,its CAS NO. is 9001-13-2,the synonyms is Hemocoagulase ; Coagulase ; Hemocoagulase (batroxobin) ; Botropase (ravizza) ; Difibrase ; Ophidiase (labaz) ; Reptilase to injection .