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| CAS No.: | 9005-65-6 | |||
|---|---|---|---|---|
| Name: | Tween 80 | |||
| Molecular Structure: | ||||
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| Formula: | C24H44O6 | |||
| Molecular Weight: | 428.600006103516 | |||
| Synonyms: | Sorbitan,mono-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs., (Z)-;Sorbitan,monooleate, polyoxyethylene derivs. (8CI);Glycols, polyethylene, ether withsorbitan monooleate (8CI);Alkamuls PSMO 20;Alkamuls T 80;Atlox 1087;Atlox8916TF;Canarcel TW 80;Capmul POE-O;Cemerol T 80;Cemesol TW 1020;Crill 10;Crill 11;Crill S 10;Crillet 4;Crillet 4 HP;Crillet 4 Super;Crillet 41;Crodalan AWS;Disponil SMO 120;Disponil SMO 120 Spez;Durfax 80;E 433;E 433(polyglycol);Ecoteric 20;Ecoteric T 80;Emalex ET 8020;Emasol O 105R;Emsorb6900;Emulson 10OM;Ethoxylated sorbitan monooleate;Ethsorbox O 20;Ethylan GE08;Ethylene oxide-sorbitan monooleate polymer;Eumulgin SMO 20;Flo Mo SMO 20;Glycosperse O 20;Glycosperse O 5;Hexaethylene glycol sorbitan monooleate;Hodag SVO 9;Ionet T 80;Ionet T 80C;Ionet T 80V;Ionet-T 80PA;Lamesorb SMO20;Liposorb O 20VBE;MO 55F;Montanox 80;Montanox 81VG;Montanox DF 80;Myvatex MSPS;Nikkol TO 10;Nikkol TO 106;Nikkol TO 10M;Nikkol TO 10MV;Nikkol TO 10V;Nissan Nonion OT 220;Nissan Nonion OT 221;Nofable ESO 9920;Nonio-light 0-30;Nonio-light SPO 1;Nonion OT 220;Nonion OT 221;Olothorb;PEG sorbitan monooleate;PEO(20) sorbitan monooleate;POE sorbitan monooleate;Polisorbac 60;Polyethoxylated sorbitan monooleate;Polyethylene glycolsorbitan ether monooleate;Polyethylene glycol sorbitan monooleate;Polyoxyethylated sorbitan monooleate;Polyoxyethylene monosorbitan monooleate;Polyoxyethylene sorbitan monooleate;Polyoxyethylenesorbitan oleate;Polysorban80;Polysorbate 80;Polysorbate 81;Radiasurf 7157;Rheodol Super TW-O 120;Rheodol TQ-O 106;Rheodol TW 0120V;Rheodol TW-O 106;Rheodol TW-O 106V;Rheodol TW-O 120;Rheodol TW-O 120V;Romulgin O;SVO 9;Setrolene O;Silvan T80;Simugel EG;Sorbax PMO 20;Sorbimacrogol oleate;Sorbimacrogol oleate 100;Sorbimacrogol oleate 300;Sorbital O 20;Sorbitan monooleate ethylene oxideadduct;Sorbitan monooleate polyethylene glycol ether;Sorbitan monooleatepolyoxyethylene ether;Tween 80; | |||
| EINECS: | 500-019-9 | |||
| Density: | 1.064 | |||
| Melting Point: | -21oC | |||
| Boiling Point: | > 100 C | |||
| Flash Point: | >110 ºC | |||
| Solubility: | Soluble | pale yellow oily liquid | ||
| Hazard Symbols: | UN NO. | |||
| Risk Codes: | 22-36/37/38-37/38-41 | |||
| Safety: | Moderately toxic by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes. | |||
| Transport Information: | 200kgs | |||
| PSA: | 133.14000 | |||
| LogP: | 4.46260 | |||
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Consensus Reports
Specification
The Tween 80,with the CAS registry number 61791-14-8, is also known as Polyoxyethylene sorbitan monooleate;Sorbimacrogol oleate 300; Sorbital 0 20. It belongs to the product categories of Organics;Catalyst and assistant;assistant. What's more,Its systematic name is Polyoxyethylene sorbitan monooleate. The Tween 80 is Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives,complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.
Uses of Tween 80:
(1).Polysorbate 80 is often used in ice cream to prevent milk proteins from completely coating the fat droplets.
(2).Polysorbate 80 is also used as an emulsifier in the manufacture of medications for parenteral administration, most notably in the popular anti-arrhythmic amiodarone.
Safety and Storage of the Tween 80:
The Tween 80 is moderately toxic by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.When you contact it avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes,avoid ingestion and inhalation.As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.And it Store in a cool, dry place. Store in a tightly closed container. Store at around 20°C.
The toxicity data of Tween 80 as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intravenous | 500mg/kg (500mg/kg) | CARDIAC: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1586, 1978. |
| dog | LDLo | intravenous | 500mg/kg (500mg/kg) | CARDIAC: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1586, 1978. |
| mammal (species unspecified) | LD50 | intravenous | 5800mg/kg (5800mg/kg) | Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 459, 1991. | |
| mammal (species unspecified) | LD50 | oral | 25gm/kg (25000mg/kg) | Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 459, 1991. | |
| mouse | LD50 | intraperitoneal | 7600mg/kg (7600mg/kg) | Pharmacology and Therapeutics. Vol. 5, Pg. 467, 1979. | |
| mouse | LD50 | intravenous | 4500mg/kg (4500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 666, 1968. | |
| mouse | LD50 | oral | 25gm/kg (25000mg/kg) | Bollettino Chimico Farmaceutico. Vol. 101, Pg. 173, 1962. | |
| rat | LD50 | intraperitoneal | 6804mg/kg (6804mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 804, 1985. | |
| rat | LD50 | intravenous | 1790mg/kg (1790mg/kg) | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 254, 1974. | |
| rat | LD50 | oral | 34500uL/kg (34.5mL/kg) | Food Research. Vol. 21, Pg. 348, 1956. |