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9039-53-6

Basic Information
CAS No.: 9039-53-6
Name: Kinase(enzyme-activating), uro-
Molecular Structure:
Molecular Structure of 9039-53-6 (Kinase(enzyme-activating), uro-)
Formula: Unspecified
Molecular Weight: 0
Synonyms: Abbokinase;Actosolv;Breokinase;Double-chainurokinase-type plasminogen activator;E.C. 3.4.21.31;E.C. 3.4.21.73;E.C.3.4.99.26;Persolv;Plasminokinase, urinary;Pro-HGF convertase;Pro-hepatocytegrowth factor convertase;Purochin;Two-chain urokinase;Two-chainurokinase-type plasminogen activator;Ukidan;Urokinase;Urokinase plasminogenactivator;Urokinase-like plasminogen activator;Urokinase-type plasminogenactivator;Uronase;Win 22005;Win-Kinase;
EINECS: 232-917-9
Density:
Melting Point:
Boiling Point:
Flash Point:
Solubility: Reconstitute in water at 100µg/ml
Appearance:
Hazard Symbols: B
Risk Codes:
Safety:
Transport Information:
PSA: 0.00000
LogP: 0.00000
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    9039-53-6

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    9039-53-6

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The systematic name of Urokinase is Kinase (enzyme-activating), uro-. With the CAS registry number 9039-53-6, it is also named as Abbokinase. The product's classification codes are Drug / Therapeutic Agent; Plasminogen activator; Plasminogen Activators; Reproductive Effect; TSCA Flag XU [Exempt from reporting under the Inventory Update Rule], and the other registry numbers are 139639-24-0; 37211-64-6. Besides, it is white powder, which should be sealed in brown glass bottle at 2-8 °C. This chemical is a serine protease. In addition, The most important inhibitors of this chemical are the serpins plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator inhibitor-2 (PAI-2).

Preparation and Uses of Urokinase: this chemical was originally isolated from human urine. Additionally, this product can be used as anticancer agents. Moreover, it has been used clinically in the treatment of severe or massive deep venous thrombosis, pulmonary embolism, myocardial infarction, and occluded intravenous or dialysis cannulas as a thrombolytic agent.

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 909ug/kg (0.909mg/kg)   Drugs in Japan Vol. -, Pg. 164, 1990.
mouse LD50 intravenous > 3000ku/kg (3000000iu/kg)   Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 514, 1981.
mouse LD50 oral > 2727ug/kg (2.727mg/kg)   Drugs in Japan Vol. -, Pg. 164, 1990.
mouse LD50 subcutaneous > 2727ug/kg (2.727mg/kg)   Drugs in Japan Vol. -, Pg. 164, 1990.
rat LD50 intravenous > 3000ku/kg (3000000iu/kg)   Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 514, 1981.
rat LD50 oral > 2727ug/kg (2.727mg/kg)   Drugs in Japan Vol. -, Pg. 164, 1990.
rat LD50 subcutaneous > 2727ug/kg (2.727mg/kg)   Drugs in Japan Vol. -, Pg. 164, 1990.