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CAS No.: | 919797-20-9 |
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Name: | 25I-NBOH HCL |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C17H20INO3 |
Molecular Weight: | 413.255 |
Synonyms: | NBOH-2CI;25I-NBOH;25I-NBOH HCL;Cimbi-27; |
Density: | 1.493±0.06 g/cm3(Predicted) |
Boiling Point: | 497.0±45.0 °C(Predicted) |
PSA: | 50.72000 |
LogP: | 3.73720 |
25I-NBOH (NBOH-2CI, Cimbi-27, 2-C-I-NBOH) is a derivative of the phenethylamine derived hallucinogen 2C-I that was discovered in 2006 by a team at Purdue University. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, similar to the better-known compound 25I-NBOMe, making it some twelve times the potency of 2C-I itself. In vitro tests showed this compound acted as an agonist but animal studies have not been reported. While the N-benzyl derivatives of 2C-I were significantly increased in binding activity to 5HT2A receptor fragments, compared to 2C-I, the N-benzyl derivatives of DOI were less active, compared to DOI.
25I-NBOH is notable as one of the most selective agonist ligands for the 5-HT2A receptor with an EC50 value of 0.074 nM and more than 400x selectivity over the 5-HT2C receptor.