CAS No.93793-83-0,Roxatidine acetate hydrochloride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	93793-83-0
Name:	Roxatidine acetate hydrochloride
Article Data:	6

Formula:	C₁₉H₂₈N₂O₄^.ClH
Molecular Weight:	384.903
Synonyms:	Altat (TN);Roxatidine acetate hydrochloride (JAN/USAN);Acetamide,2-(acetyloxy)-N-[3-[3-(1- piperidinylmethyl)phenoxy]propyl]-,monohydrochloride;Altat;Roxatidine aceacetate HCl;Acetamide,2-(acetyloxy)-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-monohydrochloride;Roxatidine Acetate HCl;
EINECS:	685-494-1
Melting Point:	145-146°
Boiling Point:	537.3 °C at 760 mmHg
Flash Point:	278.7 °C
PSA:	67.87000
LogP:	3.25150

Raw Materials

110-89-4

108441-34-5

127-08-2

73279-04-6

73278-98-5

100-83-4

Total:149 Page 1 of 4 1 2 3 4 Next>>

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Chemistry

IUPAC Name: [2-Oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate hydrochloride
Molecular Formula: C₁₉H₂₈N₂O₄^.HCl
Molecular Weight: 384.90 g/mol
Canonical SMILES: c1(cc(ccc1)OCCCNC(COC(C)=O)=O)CN1CCCCC1.Cl
InChI: InChI=1/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23);1H
Product Categories: Miscellaneous Biochemicals
Classification Code: Anti-ulcerative; Drug / Therapeutic Agent; Histamine Agents; Histamine Antagonists; Histamine H2 antagonists; Neurotransmitter Agents; Reproductive Effect
Flash Point: 278.7 °C
Enthalpy of Vaporization: 81.42 kJ/mol
Boiling Point: 537.3 °C at 760 mmHg
Vapour Pressure of Roxatidine acetate hydrochloride (CAS NO.111470-99-6): 1.29E-11 mmHg at 25 °C

Uses

Roxatidine acetate hydrochloride (CAS NO.111470-99-6) is used as antiulcerative agents.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	75mg/kg (75mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 1167, 1985.
dog	LD50	oral	100mg/kg (100mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 1167, 1985.
monkey	LD50	intravenous	50mg/kg (50mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 1167, 1985.
mouse	LD50	intravenous	83mg/kg (83mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 1167, 1985.
mouse	LD50	oral	509mg/kg (509mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 1167, 1985.
mouse	LD50	subcutaneous	384mg/kg (384mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 1167, 1985.
rabbit	LD50	oral	900mg/kg (900mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 1167, 1985.
rat	LD50	intraperitoneal	227mg/kg (227mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 1167, 1985.
rat	LD50	intravenous	110mg/kg (110mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 1167, 1985.
rat	LD50	oral	755mg/kg (755mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 1167, 1985.
rat	LD50	subcutaneous	595mg/kg (595mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 1167, 1985.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and HCl. See also ESTERS.

Specification

Roxatidine acetate hydrochloride (CAS NO.111470-99-6), its Synonyms are 2-Acetoxy-N-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)acetamide hydrochloride ; 2-Hydroxy-N-(3-(m-(piperidinomethyl)phenoxy)propyl)acetamide acetate (ester) hydrochloride ; Aceroxatidine hydrochloride ; Acetamide, 2-(acetyloxy)-N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-, monohydrochloride ; N-(3-((alpha-Piperidino-m-tolyl)oxy)propyl)glycolamide acetate (ester), monohydrochloride .