CAS No.94-24-6,Tetracaine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	94-24-6
Name:	Tetracaine
Article Data:	10

Formula:	C₁₅H₂₄N₂O₂
Molecular Weight:	264.368
Synonyms:	Benzoicacid, p-(butylamino)-, 2-(dimethylamino)ethyl ester (8CI);2-Dimethylaminoethylp-butylaminobenzoate;Amethocaine;Ametop;Anetain;Butylocaine;Contralgin;Fissucain;Intercain;Laudocaine;Medicaine;Medihaler-Tetracaine;Meethobalm;Metraspray;Mucaesthin;Pontocaine;Rexocaine;Uromucaesthin;b-Dimethylaminoethylp-N-butylaminobenzoate;b-Dimethylaminoethyl p-butylaminobenzoate;
EINECS:	202-316-6
Density:	1.044 g/cm³
Melting Point:	41.0 to 45.0 °C
Boiling Point:	389.4 °C at 760 mmHg
Flash Point:	189.3 °C
Solubility:	156mg/L(temperature not stated)
Appearance:	White crystalline powder
Hazard Symbols:	Xn, Xi
Risk Codes:	22-40-42/43-43
Safety:	22-36/37
Transport Information:	UN 2811
PSA:	41.57000
LogP:	2.69000

Synthetic route

: 109-65-9
1-bromo-butane

: 10012-47-2
Dimethylprocaine

: 94-24-6
amethocaine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 5h;	82.8%
With butan-1-ol

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 99-77-4
ethyl 4-nitrobenzoate

: 123-72-8
butyraldehyde

: 94-24-6
amethocaine

Conditions

Conditions	Yield
With hydrogen; palladium-containing anion exchanger AV-17-8 In ethanol at 45℃; under 760 Torr; Kinetics; Further Variations:; Catalysts; concentrations;	94%
With hydrogen; palladium-containing anion exchanger AV-17-8 In ethanol at 45℃; under 760 Torr;	94%

...Expand

: 2-(dimethylamino)ethyl 4-bromobenzoate

: 109-73-9
N-butylamine

: 94-24-6
amethocaine

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; nickel(II) bromide dimethoxyethane; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate In dimethyl sulfoxide at 80℃; for 0.166667h; Flow reactor; Sealed tube; Schlenk technique; Inert atmosphere; Irradiation;	85%

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 4740-24-3
4-(N-butylamino)benzoic acid

: 94-24-6
amethocaine

Conditions

Conditions	Yield
With hydrogenchloride; toluene
With sodium hydride; 1,1'-carbonyldiimidazole In 1,2-dimethoxyethane at 60℃;

: 38152-22-6
4-nitrobenzoic acid 2-(dimethylamino)ethyl ester

: 94-24-6
amethocaine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: iron; acetic acid / 8 h / 30 °C 2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C View Scheme

: 122-04-3
4-nitro-benzoyl chloride

: 94-24-6
amethocaine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dichloromethane / 2 h / 0 °C 2: iron; acetic acid / 8 h / 30 °C 3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C View Scheme

: 94-09-7
p-aminoethylbenzoate

: 94-24-6
amethocaine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: zinc; acetic acid; benzene 2: aq.-ethanolic KOH-solution 3: toluene; hydrogen chloride View Scheme
Multi-step reaction with 2 steps 1: zinc; acetic acid; benzene 2: sodium ethylate View Scheme
Multi-step reaction with 3 steps 1: potassium carbonate; copper / 160 °C 2: aq.-ethanolic KOH-solution 3: toluene; hydrogen chloride View Scheme
Multi-step reaction with 2 steps 1: potassium carbonate; copper / 160 °C 2: sodium ethylate View Scheme

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 94-32-6
ethyl 4-(N-butylamino)benzoate

: 94-24-6
amethocaine

Conditions

Conditions	Yield
With sodium ethanolate

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 4-butylamino-benzoyl chloride ; hydrochloride

: 94-24-6
amethocaine

Conditions

Conditions	Yield
With diethyl ether
With benzene

: 4740-24-3
4-(N-butylamino)benzoic acid

: 94-24-6
amethocaine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen chloride 2: sodium ethylate View Scheme
Multi-step reaction with 2 steps 1: hydrogen chloride 2: benzene View Scheme

Raw Materials

109-65-9

94-32-6

94-09-7

99-77-4

123-72-8

108-01-0

4740-24-3

10012-47-2

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Chemistry

Product Name: Tetracaine (CAS NO.94-24-6)

Molecular Formula: C₁₅H₂₄N₂O₂
Molecular Weight: 264.36g/mol
Density:1.044 g/cm³
Boiling point:389.4 ^°C at 760 mmHg
Flash point:189.3 ^°C
Index of Refraction:1.537
Molar Refractivity:79.15 cm³
Molar Volume:253 cm³
Polarizability:31.37 10^-24cm³
Surface Tension:39.7 dyne/cm
Enthalpy of Vaporization:63.87 kJ/mol
Vapour Pressure:2.87E-06 mmHg at 25^°C
IUPAC Name: 2-dimethylaminoethyl 4-(butylamino)benzoate
Product Categories: API

Uses

It's used as narcotic drugs.

Toxicity Data With Reference

1.	dnd-esc 30 µmol/L	MUREAV Mutation Research. 89 (1981),95.
2.	dns-hmn:hla 1 µmol/L	BCPCA6 Biochemical Pharmacology. 14 (1965),205.
3.	par-man LDLo:1 mg/kg:CNS,PUL	SAVEAB Sammlung von Vergiftungsfaellen. 10 (1939),50.
4.	ivn-rat LD50:6 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 8 (1958),539.
5.	ipr-mus LD50:20 mg/kg	RPTOAN Russian Pharmacology and Toxicology. Translation of FATOAO. 35 (3)(1972),114.
6.	scu-mus LD50:25 mg/kg	PHTXA6 Pharmacology and Toxicology. Translation of FATOAO. 20 (1957),521.
7.	ivn-mus LD50:6 mg/kg	EJMCA5 European Journal of Medicinal Chemistry. Chimie Therapeutique. 10 (1975),291.
8.	scu-rbt LDLo:20 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 160 (1931),53.
9.	ivn-rbt LDLo:6 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 160 (1931),53.
10.	par-rbt LD50:33,500 µg/kg	ARZNAD Arzneimittel-

Safety Profile

A human poison by parenteral route with systemic effects including: muscle contractions, coma, and cyanosis. A poison experimentally by intravenous, parenteral, intratracheal, intraperitoneal, and subcutaneous routes. Human mutation data reported. A local anesthetic. See also ESTERS. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes:Xn,Xi
Xi:Irritant
Xn:Harmful
Risk Statements
R22:Harmful if swallowed.
R40:Limited evidence of a carcinogenic effect.
R42/43:May cause sensitization by inhalation and skin contact .
R43:May cause sensitization by skin contact.
Safety Statements
S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves .
RIDADR:UN 2811
RTECS:DG4725000

Specification

Tetracaine , its CAS NO. is 94-24-6, the synonyms are 2-(Dimethylamino)ethyl p-(butylamino)benzoate ; 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove ; 2-Dimethylaminoethylesterkyselinyp-butylaminobenzoove ; 2-Dimethylaminoethylp-butylaminobenzoate ; 4-(Butylamino)-benzoicaci2-(dimethylamino)ethylester ; Amethocaine ; Anetain ; 2-(Dimethylamino)ethyl 4-(butylamino)benzoate .