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CAS No.: | 96382-71-7 |
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Name: | DEHYDRO FELODIPINE-13C4 |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C18H17 Cl2 N O4 |
Molecular Weight: | 382.243 |
Synonyms: | 3,5-Pyridinedicarboxylicacid, 4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methyl ester (9CI);Dehydrofelodipine; H 152/37 |
Density: | 1.288g/cm3 |
Melting Point: | 70-73C |
Boiling Point: | 444.8°Cat760mmHg |
Flash Point: | 222.8°C |
PSA: | 65.49000 |
LogP: | 4.63550 |
ethyl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate
methyl 3-aminocrotonate
Dehydrofelodipine
Conditions | Yield |
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In ethanol at 50 - 55℃; for 8h; Darkness; Large scale; | 90% |
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Dehydrofelodipine
Conditions | Yield |
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With potassium carbonate; eosin Y bis(tetrabutyl ammonium salt) In methanol; water at 20℃; for 12h; Irradiation; Green chemistry; | 83% |
With potassium carbonate In ethanol; water at 20℃; for 12h; | 83.1% |
Stage #1: ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate With hydrogenchloride In water Stage #2: With nickel In water at 20℃; for 4h; | 72.4% |
With potassium phosphate; ethylenediaminetetraacetic acid; Emulgen 911; human liver cytochrome b5; human liver HL 39 lipid extract; rabbit liver NADPH-P-450 reductase; yeast P-450 IIIA4; magnesium chloride In water Rate constant; other human liver enzymes; |
ethyl acetoacetate
acetoacetic acid methyl ester
2,3-dichlorobenzylaldehyde
Dehydrofelodipine
Conditions | Yield |
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Multi-step reaction with 2 steps 1: ammonium acetate / ethanol / 2 h / 80 °C 2: eosin Y bis(tetrabutyl ammonium salt); potassium carbonate / water; methanol / 12 h / 20 °C / Irradiation; Green chemistry View Scheme |
Conditions | Yield |
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Multi-step reaction with 2 steps 1: piperidine; acetic acid / 6 h / 15 - 55 °C / Large scale 2: ethanol / 8 h / 50 - 55 °C / Darkness; Large scale View Scheme |