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98-92-0

Basic Information
CAS No.: 98-92-0
Name: Nicotinamide
Molecular Structure:
Molecular Structure of 98-92-0 (Nicotinamide)
Formula: C6H6N2O
Molecular Weight: 122.13 .
Synonyms: Nikotinamid;Nicotylamide;beta-Pyridinecarboxamide;Vitamin B3; Niacin; Niacinmide;;nicotinamide,niacinamide;pyridine-3-carboxamide;Nicobion;Nicotamide;Nicota;Pyridine, 3-carbamoyl-;Amixicotyn;Amide PP;Nicomidol;Delonin Amide;3-Pyridinecarboxamide;NAM;Nicotine acid amide;PP-Faktor;Nicovitol;m-(Aminocarbonyl)pyridine;Nicotinic acid amide;Nicotililamido;Hansamid;Endobion;Vitamin B (VAN);Nicasir;3-Pyridinecarboxylic acid amide;Nicogen;Niacinamide (USP);Nicosan 2;Amnicotin;Pelmine;Nicotinic amide;Savacotyl;Nicofort;Niavit PP;Nicotinamida [INN-Spanish];DEA No. 1405;a-Alanine,N-[(2R)-2,4-dihydroxy-3,3- dimethyl-1-oxobutyl]- [79-83-4] 3-Pyridinecarboxamide;3-Carbamoylpyridine;Niacinamide [USAN];Papulex;Nicotinamide(Vitamin B3);Nikotinsaeureamid [German];Aminicotin;Nicosylamide;Nicovit;
EINECS: 202-713-4
Density: 1.204 g/cm3
Melting Point: 128-131 °C
Boiling Point: 334.4 °C at 760 mmHg
Flash Point: 156 °C
Solubility: Incompatible with strong oxidizing agents
Appearance: White to off white powder
Hazard Symbols: IrritantXi
Risk Codes: 36/37/38
Safety: 26-36-37/39
Transport Information:
PSA: 55.98000
LogP: 0.88080
Synthetic route
100-54-9

pyridine-3-carbonitrile

98-92-0

nicotinamide

Conditions
ConditionsYield
With manganese(IV) oxide; silica gel In hexane for 8h; Heating;100%
With manganese(IV) oxide; silica gel In chlorobenzene for 5h; Heating;100%
With water at 30℃; for 5.5h; Large scale reaction; Enzymatic reaction;99%
144223-30-3

(1H-benzo[d][1,2,3]triazol-1-yl)(pyridin-3-yl)methanone

98-92-0

nicotinamide

Conditions
ConditionsYield
With ammonium hydroxide In tetrahydrofuran; ethanol at 20℃; for 4h;100%
3731-52-0

3-Aminomethylpyridine

98-92-0

nicotinamide

Conditions
ConditionsYield
With manganese(IV) oxide at 130℃; under 4560.31 Torr; for 3h;98%
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); potassium tert-butylate In tert-butyl alcohol at 70℃; for 12h;96%
With oxygen; potassium carbonate; copper(I) bromide In water; dimethyl sulfoxide at 140℃; under 760.051 Torr; for 6h;90%
500-22-1

3-pyridinecarboxaldehyde

98-92-0

nicotinamide

Conditions
ConditionsYield
With C55H45ClN5P2Ru(1+)*Cl(1-); hydroxylamine hydrochloride; sodium carbonate In water at 110℃; for 12h; Sealed tube;95%
With C17H17BrClN2RuSe(1+)*F6P(1-); hydroxylamine hydrochloride; sodium hydroxide In toluene at 100℃; for 12h; Reagent/catalyst; Solvent; Temperature;91%
With hydroxylamine hydrochloride; methanesulfonyl chloride In neat (no solvent) at 70℃; for 3.5h;90%
4621-66-3

thionicotinamide

98-92-0

nicotinamide

Conditions
ConditionsYield
With thionyl chloride; dihydrogen peroxide In ethanol at 25℃; for 0.0166667h;94%
With chloro-trimethyl-silane; dihydrogen peroxide In ethanol; water at 25℃; for 0.133333h; regioselective reaction;92%
With sodium hydroxide; copper(l) chloride In water; acetonitrile at 25℃; for 0.166667h;88%
With nitrosonium tetrafluoroborate In dichloromethane for 8h; Ambient temperature;74%
With potassium superoxide; 18-crown-6 ether for 1h; Ambient temperature;71%
1986-81-8

nicotinamide N-oxide

98-92-0

nicotinamide

Conditions
ConditionsYield
With titanium tetrachloride; tin(ll) chloride In diethyl ether for 0.5h; Ambient temperature;93%
With indium; ammonium chloride In methanol; water for 5h; Reduction; Heating;91%
With molybdenum(V) chloride; sodium iodide In acetonitrile at 20℃; for 2h;91%

C22H27N5O15P2

A

98-92-0

nicotinamide

B

C16H21N3O14P2

Conditions
ConditionsYield
With Aplysia cyclase at 23℃;A n/a
B 92%
1120-90-7

3-iodopyridine

201230-82-2

carbon monoxide

98-92-0

nicotinamide

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; N-methoxylamine hydrochloride; sodium iodide; palladium dichloride In acetonitrile at 90℃; under 3800.26 Torr; for 8h; Autoclave; Inert atmosphere;92%
With 1,4-diaza-bicyclo[2.2.2]octane; palladium 10% on activated carbon; ammonium carbamate; potassium iodide In acetonitrile at 90℃; for 8h; Autoclave; Green chemistry;85%
626-55-1

3-Bromopyridine

potassiumhexacyanoferrate(II) trihydrate

98-92-0

nicotinamide

Conditions
ConditionsYield
With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In water; dimethyl sulfoxide at 120℃; for 20h; Inert atmosphere; Sealed tube;92%
100-55-0

3-hydroxymethylpyridin

98-92-0

nicotinamide

Conditions
ConditionsYield
With tert.-butylhydroperoxide; ammonia; oxygen In water; N,N-dimethyl-formamide at 80℃; under 1520.1 Torr; for 5h; Green chemistry;91%
With ammonium hydroxide; cryptomelane; oxygen In 1,4-dioxane at 130℃; under 2280.15 Torr; for 2h; Autoclave; Green chemistry;89%
Stage #1: 3-hydroxymethylpyridin With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonia; oxygen; copper(II) nitrate In water; dimethyl sulfoxide at 80℃; under 760.051 Torr; for 5h;
Stage #2: With Acetaldehyde oxime In water; dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere;
89%
3731-52-0

3-Aminomethylpyridine

A

100-54-9

pyridine-3-carbonitrile

B

98-92-0

nicotinamide

Conditions
ConditionsYield
With water; oxygen at 140℃; under 3800.26 Torr; for 24h;A n/a
B 90%
With ammonia; oxygen; vanadia at 375℃; Product distribution; other catalysts, effect of the presence of O2;
With ammonia In 1,4-dioxane; water at 130℃; under 4560.31 Torr; for 3h; Autoclave;A 7 %Chromat.
B 84 %Chromat.

nicotinamide guanine dinucleotide

A

98-92-0

nicotinamide

B

cyclic-GDP-ribose

Conditions
ConditionsYield
With phosphate buffer; Aplysia cyclase at 23℃; for 5h; pH=7.0;A n/a
B 90%
51892-16-1

nicotinaldehyde oxime

98-92-0

nicotinamide

Conditions
ConditionsYield
With aluminum oxide; water; methanesulfonyl chloride at 100℃; for 0.25h;90%
1193-92-6

3-pyridinealdoxime

98-92-0

nicotinamide

Conditions
ConditionsYield
With C55H45ClN5P2Ru(1+)*Cl(1-) In water at 110℃; for 12h; Sealed tube;90%
With copper(II) acetate monohydrate In ethanol; acetonitrile for 5.5h; Time; Reflux;89.74%
With cis,cis,trans-[RuCl2{κ2-(P,N)-2-Ph2PC6H4CH=NOH}2] In water at 100℃; for 6h; Sealed tube; Inert atmosphere;86%
626-55-1

3-Bromopyridine

201230-82-2

carbon monoxide

98-92-0

nicotinamide

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; ammonium carbamate; sodium hydrogencarbonate In 1,4-dioxane at 100℃; for 20h; Inert atmosphere;89%
With 2-(2'-pyridyl)(di(1-adamantyl)phosphino)benzene; ammonia; palladium diacetate In 1,4-dioxane at 120℃; under 1500.15 Torr; for 16h; Autoclave;76%
With ammonia; palladium diacetate; catacxium A In 1,4-dioxane at 100℃; under 3000.3 Torr; for 16h; Autoclave;90 %Chromat.
With 1,1'-bis-(diphenylphosphino)ferrocene; ammonia; palladium diacetate In 1,4-dioxane at 100℃; under 1500.15 Torr; for 16h;94 %Chromat.
With ammonia; palladium diacetate; catacxium A In 1,4-dioxane at 100℃; under 1500.15 Torr; for 16h; Autoclave;
626-55-1

3-Bromopyridine

98-92-0

nicotinamide

Conditions
ConditionsYield
With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 90℃; for 3h; Sealed tube;89%
59-67-6

nicotinic acid

98-92-0

nicotinamide

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate; urea for 0.025h; microwave irradiation;88%
With ammonium chloride; triethylamine at 20℃; for 0.0166667h;87%
Stage #1: nicotinic acid With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: With ammonium chloride In tetrahydrofuran; water at 0℃; for 0.5h;
84%
108-99-6

3-Methylpyridine

98-92-0

nicotinamide

Conditions
ConditionsYield
With ammonium nitrate; oxygen at 120℃; under 37503.8 Torr; for 24h; Autoclave;83%
With tert.-butylhydroperoxide; cobalt ferrite; ammonium chloride; calcium carbonate In water; acetonitrile at 80℃; for 9h; Inert atmosphere; Green chemistry;53%
With manganese(IV) oxide; carbon dioxide; ammonia at 155℃; under 22502.3 Torr; for 3.5h; Temperature; Pressure;

nicotinamide hypoxanthine 5′-dinucleotide

A

98-92-0

nicotinamide

B

cyclic-HDP-ribose

Conditions
ConditionsYield
With phosphate buffer; Aplysia cyclase at 23℃; for 5h; pH=7.0;A n/a
B 81%
1120-90-7

3-iodopyridine

potassium ferrocyanide

98-92-0

nicotinamide

Conditions
ConditionsYield
With water; potassium carbonate In dimethyl sulfoxide at 110℃; for 12h;81%
4013-72-3

nicotinoyl azide

98-92-0

nicotinamide

Conditions
ConditionsYield
With thiamine diphosphate In methanol at 80℃; for 1h;80%
626-60-8

3-Chloropyridine

201230-82-2

carbon monoxide

98-92-0

nicotinamide

Conditions
ConditionsYield
With (1,3-(dicyclohexylphosphino)propane )Pd(ethylene); ammonia; potassium carbonate In dimethyl sulfoxide at 110℃; under 450 Torr; for 24h; Schlenk technique; Inert atmosphere;77%
With ammonia; palladium diacetate; catacxium A In 1,4-dioxane at 130℃; under 3000.3 Torr; for 20h; Autoclave;40 %Chromat.
With 1,1'-bis-(diphenylphosphino)ferrocene; ammonia; palladium diacetate In 1,4-dioxane at 130℃; under 1500.15 Torr; for 20h;54 %Chromat.
536-78-7

3-ethylpyridine

98-92-0

nicotinamide

Conditions
ConditionsYield
With tert.-butylhydroperoxide; ammonia; iodine In water at 100℃; for 3h; Sealed tube; Green chemistry;76%
100-54-9

pyridine-3-carbonitrile

50-00-0

formaldehyd

A

3569-99-1

N-hydroxymethylnicotinamide

B

98-92-0

nicotinamide

Conditions
ConditionsYield
With anion exchange resin AB-17-8 OH-form; ammonia; water at 60 - 90℃; for 1h;A 75.7%
B 23.2%
626-55-1

3-Bromopyridine

151-51-9

carbodiimide

98-92-0

nicotinamide

Conditions
ConditionsYield
With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; magnesium chloride; zinc In N,N-dimethyl-formamide at 70℃; for 24h;75%
100-54-9

pyridine-3-carbonitrile

A

100-55-0

3-hydroxymethylpyridin

B

98-92-0

nicotinamide

Conditions
ConditionsYield
With formaldehyd; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In water; toluene at 90℃;A 21%
B 74%

1-nicotinoylpiperidine-2,6-dione

98-92-0

nicotinamide

Conditions
ConditionsYield
With lithium hydroxide monohydrate In water at 20℃; for 2h;74%
350-03-8

methyl-3-pyridylketone

98-92-0

nicotinamide

Conditions
ConditionsYield
With ammonia; water; iodine In tetrahydrofuran at 20℃; for 12h; Haller-Bauer reaction;69%
2503-55-1

N-benzylnicotinamide

A

98-92-0

nicotinamide

B

100-52-7

benzaldehyde

Conditions
ConditionsYield
With N-Bromosuccinimide In chloroform at 20℃; for 20h; Product distribution;A 63%
B n/a
98-92-0

nicotinamide

100-39-0

benzyl bromide

13076-43-2

3-(aminocarbonyl)-1-benzylpyridinium bromide

Conditions
ConditionsYield
In acetone for 12h; Reflux;100%
In acetonitrile93%
In acetonitrile at 140℃; for 1.5h; Sealed tube; Microwave irradiation;89%
67-56-1

methanol

98-92-0

nicotinamide

6269-24-5

methyl-3-pyridyl carbamate

Conditions
ConditionsYield
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; mercury(II) diacetate In N,N-dimethyl-formamide for 12h; Ambient temperature; or AgOAc;100%
With aluminum oxide; potassium fluoride; sodium hypochlorite In water for 0.5h; modified Hofmann rearrangement; Heating;90%
Stage #1: nicotinamide With trichloroisocyanuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; Hofmann rearrangement; Inert atmosphere;
Stage #2: methanol at 65℃; Hofmann rearrangement; Inert atmosphere;
84%
With potassium hydroxide; [bis(acetoxy)iodo]benzene 1) 5-10 deg C, 15 min, 2) to r. t., 45 min;82%
75-77-4

chloro-trimethyl-silane

98-92-0

nicotinamide

69688-12-6

N,N-bis(trimethylsilyl)nicotinamide

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane at 150℃; for 12h;100%
With 1,1,1,3,3,3-hexamethyl-disilazane at 120℃; for 5h;
98-92-0

nicotinamide

63592-86-9

3,5-di-O-benzoyl-D-ribofuranosyl chloride

23110-99-8

3-Carbamoyl-1-(3,5-di-O-benzoyl-β-D-ribofuranosyl)-pyridiniumchlorid

Conditions
ConditionsYield
100%
98-92-0

nicotinamide

50-81-7

ascorbic acid

114374-92-4

ascorbic acid,nicotinamide

Conditions
ConditionsYield
In water pH=Ca. 3.3 - 3.9; Cooling with ice;100%
In methanol33%
27607-77-8

trimethylsilyl trifluoromethanesulfonate

98-92-0

nicotinamide

13035-61-5

1,2,3,5-tetraacetylribose

3-carbamoyl-1-((2R,3R,4R,5R)-3,4-diacetoxy-5-(acetoxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium trifluoromethanesulfonate

Conditions
ConditionsYield
Stage #1: nicotinamide; 1,2,3,5-tetraacetylribose In acetonitrile at 20℃;
Stage #2: trimethylsilyl trifluoromethanesulfonate In acetonitrile for 0.333333h;
100%
Stage #1: nicotinamide; 1,2,3,5-tetraacetylribose With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile
Stage #2: trimethylsilyl trifluoromethanesulfonate In acetonitrile at 20℃; Reagent/catalyst;
Stage #1: trimethylsilyl trifluoromethanesulfonate; nicotinamide In acetonitrile for 0.0833333h;
Stage #2: 1,2,3,5-tetraacetylribose In acetonitrile at 20℃; for 0.5h; Inert atmosphere;
In acetonitrile at -5℃; for 8h; Inert atmosphere;19 g
98-92-0

nicotinamide

98-56-6

4-chlorobenzotrifluoride

25617-45-2

N-(4-(trifluoromethyl)phenyl)nicotinamide

Conditions
ConditionsYield
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 5h; Inert atmosphere; Sonication;99.4%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;91%
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 5h; Inert atmosphere; Sonication;
98-92-0

nicotinamide

100-54-9

pyridine-3-carbonitrile

Conditions
ConditionsYield
With N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; copper(l) chloride In toluene at 100℃; for 24h;99%
With 3 A molecular sieve at 150 - 500℃; under 0.001 Torr; for 0.666667h; Pyrolysis;98%
With oxalyl dichloride; triethylamine; Triphenylphosphine oxide In acetonitrile at 20℃; for 0.166667h;96%
626-60-8

3-Chloropyridine

98-92-0

nicotinamide

13160-06-0

N-(pyridin-3-yl)pyridine-3-carboxamide

Conditions
ConditionsYield
With 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; potassium phosphate; water; palladium diacetate In tert-butyl alcohol at 110℃; for 3h; Inert atmosphere;99%
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In tert-butyl alcohol at 110℃; for 24h;97%
10025-99-7

potassium tetrachloroplatinate(II)

98-92-0

nicotinamide

Pt(C5H4NCONH2)4(2+)*2Cl(1-) = [Pt(C5H4NCONH2)4]Cl2

Conditions
ConditionsYield
In water99%
98-92-0

nicotinamide

320-67-2

5-azacytidine

5-azacytidine nicotinamide

Conditions
ConditionsYield
In methanol; water for 0.333333h;99%
98-92-0

nicotinamide

13114-65-3

1-(pyridin-3-yl)urea

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; ammonia In methanol at 0 - 20℃; for 2h; Hofmann Rearrangement; Inert atmosphere;99%
56-53-1

diethylstilbestrol

98-92-0

nicotinamide

C18H20O2*C6H6N2O

Conditions
ConditionsYield
In methanol at 50℃;98.62%
26127-08-2

(1R,2S,5R)-1-(chloromethoxy)-2-isopropyl-5-methylcyclohexane

98-92-0

nicotinamide

3-carbamoyl-1-[(1R,2S,5R)-(-)-menthoxymethyl]pyridinium chloride

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; Menschutkin quaternization;98.5%
98-92-0

nicotinamide

4138-26-5

nipecotamide

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In isopropyl alcohol at 75℃; under 3750.38 Torr; for 4h;98.4%
With hydrogen; Rh on carbon In water at 80℃; under 3800 Torr; for 1.5h;97%
With 10% Rh/C; hydrogen In water at 80℃; under 3800.26 Torr; for 1.5h;97%
98-92-0

nicotinamide

1986-81-8

nicotinamide N-oxide

Conditions
ConditionsYield
With dihydrogen peroxide; VxSi4xO6.4x In acetonitrile at 80℃; for 3h;98%
With 2,2,2-Trifluoroacetophenone; dihydrogen peroxide; acetonitrile In tert-butyl alcohol at 20℃; for 18h; Green chemistry; chemoselective reaction;95%
With 1,2-diphenyl-1,1,2,2-tetrahydroperoxyethane In acetonitrile at 20℃; for 0.233333h;87%
64648-13-1, 81115-85-7, 81115-90-4

S-Ethenyl-S-(4-methylphenyl)-N-tolylsulfilimine

98-92-0

nicotinamide

40055-37-6

2-(pyridin-3-yl)-4,5-dihydrooxazole

Conditions
ConditionsYield
With sodium hydride In 1,2-dimethoxyethane at 20 - 40℃; for 29h;98%
49791-06-2

1-chloromethoxy-heptane

98-92-0

nicotinamide

3-carbamoyl-1-heptyloxymethyl-pyridinium; chloride

Conditions
ConditionsYield
at 20℃; for 1h;98%
24566-91-4

1-chloromethoxy-nonane

98-92-0

nicotinamide

3-carbamoyl-1-nonyloxymethyl-pyridinium; chloride

Conditions
ConditionsYield
at 20℃; for 1h;98%
77412-96-5

1-trifluoromethanesulfonyloxy-4-t-butylcyclohexene

98-92-0

nicotinamide

N-(4-tert-butylcyclohexen-1-yl)nicotinamide

Conditions
ConditionsYield
With potassium carbonate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium (0) In tert-butyl alcohol at 80℃; for 24h;98%
119-65-3

isoquinoline

98-92-0

nicotinamide

762-42-5

dimethyl acetylenedicarboxylate

C21H19N3O5

Conditions
ConditionsYield
In dichloromethane at 20℃; for 24h;98%
98-92-0

nicotinamide

78282-91-4

1-(2-bromomethylbenzyl)-4-hydroxyiminomethylpyridinium bromide

3-carbamoyl-2'-hydroxyiminomethyl-1,1'-(1,4-phenylenedimethylene)-bispyridinium dibromide

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 70℃; for 3.5h;98%
In N,N-dimethyl-formamide at 80℃; for 5h;56%
98-92-0

nicotinamide

84057-84-1

lamotrigine

1151890-36-6

C6H6N2O*C9H7Cl2N5

Conditions
ConditionsYield
at 125℃; for 2.5h;98%
In methanol at 50℃; for 2h;
2508-29-4

5-hydroxypentylamine

98-92-0

nicotinamide

1613058-38-0

N-(5-hydroxypentyl)nicotinamide

Conditions
ConditionsYield
With niobium(V) oxide In neat (no solvent) at 160℃; Sealed tube; Inert atmosphere;98%
3731-52-0

3-Aminomethylpyridine

98-92-0

nicotinamide

25297-38-5

N-(pyridin-3-ylmethyl)nicotinamide

Conditions
ConditionsYield
With benzoic acid In para-xylene at 130℃; for 8h; Inert atmosphere; Schlenk technique;98%
112-71-0

1-Bromotetradecane

98-92-0

nicotinamide

5442-84-2

3-carbamoyl-1-tetradecylpyridinium bromide

Conditions
ConditionsYield
In acetonitrile for 48h; Reflux;98%
Downstream Products
122775-94-4
78210-60-3
  • Nicotinamide

  • Casno:

    98-92-0

    Nicotinamide

    Min.Order: 1 Gram

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  • Nicotinamide

  • Casno:

    98-92-0

    Nicotinamide

    Min.Order: 25 Kilogram

    FOB Price:  USD $ 1.0-1.0/Kilogram

    Paula Chem is affiliated to Zhejiang Paula Industry Co., Ltd. The registered capital of parent company is ¥50 million. The company has self-managerial import and export rights and dangerous goods business license. Paula was founded i

    Paula Chem is affiliated to Zhejiang Paula Industry Co., Ltd. The registered capital of parent company is ¥50 million. The company has self-managerial import and export rights and

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    Address:6th floor, building 2, dongfangmao business center, Xiacheng District, Hangzhou City, Zhejiang Province

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  • Nicociamide  Vitamin B3  98%

  • Casno:

    98-92-0

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    Nicotinamide is a watersoluble vitamin, The product is white crystalline powder, odorless or nearly odorless, bitter in taste, freely soluble in water or ethanol, dissolvable in glycerin. Nicotinamide is easy to absorb oral, and can be widely distrib

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  • High quality niacinamide supplier in China

  • Casno:

    98-92-0

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    Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

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    98-92-0

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  • Nicotinamide/3-Pyridinecarboxamide CAS No. 98-92-0

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    98-92-0

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  • Nicotinamide

  • Casno:

    98-92-0

    Nicotinamide

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  • Factory Supply  Vitamin B3 (Niacinamide)

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    98-92-0

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    We are manufacturer of this product. If you are looking for the material's manufacturer or supplier in China, Ality Group is your best choice. Specifications of our Mercuric oxycyanide CAS 98-92-0: Items

    Ality Group, established in 2007, is a comprehensive Chemical Supply Group with Patent Technology as its core. Ality Group operates branches in Hong Kong, Singapore and mainland Ch

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  • pharma / food grade raw material API Nicotinamide USP in China

  • Casno:

    98-92-0

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    Product Name: Niacinamide Quality: CP/BP/USP/EP Packing: 25kg/drum MOQ: 25kg Origin: China Sample: Can provide Certificate: GMP, ISO, KOSHER, HALAL Application: belong to VB3. Pharma/Feed/Food/Cos,etics field Welcome

    JOSUN INTERNATIONAL LIMITED is a pharmaceutical company which is integrated with manufacturing, marketing, RD in China. It was founded in Hong Kong and established an office in Shi

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    China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86-311-80715268 80766839

    Address:No.39, Zhaiying Street, Shijaizhuang,Hebei,China

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  • Nicotinamide

  • Casno:

    98-92-0

    Nicotinamide

    Min.Order: 0 Metric Ton

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    Shanghai Yanchu Chemicals is dedicated to providing fine chemicals, building blocks and electronic chemcials with strictly quality contol . We have well equipped labs to provid

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    Business Type:Lab/Research institutions

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    Address:Room 1292, Building NO. 2, Lane 65, Huandong 1st Rd, Fengjing Town, Jinshan Distriction, shanghai

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  • Niacinamide

  • Casno:

    98-92-0

    Niacinamide

    Min.Order: 0

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    Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

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  • Nicotinamide

  • Casno:

    98-92-0

    Nicotinamide

    Min.Order: 0

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    Founded in 1995, Shanghai Rich Chemicals Co., Ltd. is a privately held chemical industry group company. With a strong focus on the development of high purity, high performance prod

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    Business Type:Trading Company

    Tel:+86-21-20255798

    Address:Pudong Shanghai,China

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  • Good Price Food Grade Nicotinamide(vitamin b3)98-92-0

  • Casno:

    98-92-0

    MSDS/COA Download

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    Min.Order: 25 Kilogram

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    Introduction Nicotinamide/Vitamin b3 is a watersoluble vitamin, The product is white crystalline powder, odorless or nearly odorless, bitter in taste,freely soluble in water or ethanol, dissolvable in glycerin.Nicotinamide is easy to absorb oral,

    Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries. Annually, mo

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    Business Type:Other

    Tel:86-29-86107037-8015

    Address:No.11 Daqing Road,Lianhu District,Xi’an 710082,China

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  • Nicotinamide

  • Casno:

    98-92-0

    Nicotinamide

    Min.Order: 1 Kilogram

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    Product Description: Product name Nicotinamide CAS 98-92-0 Assay ≥99% Appearance White crystalline powder Capacity 500mt/year Min.package 100gram Application

    Jinan Finer Chemical Co., Ltd is professional to manufacture and R&D chemical intermediates, pharmaceutical intermediates and fine chemicals. Company locates in Jinan city new mate

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    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-531-88989536

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    98-92-0

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    Min.Order: 1 Kilogram

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    Nicotinamide Product name:Nicotinamide Chemical name:Pyridine-3-Carboxyamide Chemical structural formula:C6H6N2O=122.13 Physical

    Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of

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    Business Type:Manufacturers

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    Address:Zhang zhe, guangzong county, xingtai city, hebei province

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  • Casno:

    98-92-0

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    Wuhan Fortuna Chemical Co., Ltd, located in the predominant Wu Han City where is a traffic hinge of China, is a big integrative chemical enterprise being engaged in producing and

  •  Wuhan Fortuna Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-27-59207852

    Address:A2705,Dong Yi Shi Qu,129# XinHua Road,WuHan,China

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    98-92-0

    CHemwill -- Nicotinamide

    Min.Order: 1 Metric Ton

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    Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Fine chemicals, Active pharmaceutical ingredients(APIs), Veterinary, In

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:021-51086038

    Address:High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China

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  • Casno:

    98-92-0

    Nicotinamide

    Min.Order: 1 Kilogram

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    Nicotinamide Product Name: Nicotinamide Molecular Weight: 122.13 CAS NO: 98-92-0 EC NO: 202-713-4 Molecular Formula: C6H6N2O

    Founded in 2008, East Chemsources Limited is a professional manufacturer of supplier in food and beverage, pharmaceuticals, cosmetics and other industries. pharmaceutical field in

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    China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-532-81906761

    Address:No.1581-12,Jinshui Road, Licang, Qingdao,China

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  • Casno:

    98-92-0

    98-92-0 Nicotinamide

    Min.Order: 1 Gram

    FOB Price:  USD $ 40.0-50.0/Gram

    1.good quality 1) good quality is the basic of our goal; 2) we can offer samples to be tested; 3) 98% of our products have exported to uk, usa, germany, spain, australia, middle east and many other countries. 4) Good feedback of quality from our cu

    Mulei (Wuhan) New Material Technology Co. Ltd is a scientific and technological company integrating product research and development, manufacture and trading of chemical intermedia

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8619831967063

    Address:Office1201#, Block C, Hanjie Headquarters International Plaza, Zhongbei Rd, Wuchang District, Wuhan

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    98-92-0

    Factory high quality Nicotinamide with best price

    Min.Order: 1 Kilogram

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    1. Any inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. OEM/ODM Available. 5. Reasonable & competitive price, fast lead time. 6. Sample is available for your eva

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  •  Shanghai Bokchang Chemical Science and Technology Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-021-60459206

    Address:No388 Xinge Road ,Songjiang District,Shanghai ,China

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    98-92-0

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    Factory supply high quality Nicotinamide,98-92-0 TAIHO Unique Advantages: 1.We're factory 2.Free samples available 3.Commodity inspection can be done 4.ISO9001,Kosher certifications 5.10 years experiences Appearance:Needle white crystal or powde

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

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    Address:No. 49 taifeng Road,Qianjiang City,Hubei,China

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  • Casno:

    98-92-0

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-89925085

    Address:Watts Cosine.No.166.Xiangmao Road.

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  • Casno:

    98-92-0

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    98-92-0 Nicotinamide High Purity Nicotinamide is a watersoluble vitamin, The product is white crystalline powder, odorless or nearly odorless, bitter in taste, freely soluble in water or ethanol, dissolvable in glycerin. Nicotinamide is easy to a

    Arshine Group, set up in Shenzhen in 2007, is one of the leading Health Medicine Raw Materials and Food Raw Materials exporters in China. Arshine Group has obtained international I

  •  Arshine Pharmaceutical Co., Limited

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:0731-88503671

    Address:Room 1109.Block C3, Lugu Enterprise Plaza,No.27 Wenxuan Road,Changsha National Hi-Tech Industrial Development Zone,Hunan ,P.R.China

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  • Raw Material Vitamin B3 serum Nicotinic Acid 99% niacinamide

  • Casno:

    98-92-0

    MSDS/COA Download

    Raw Material Vitamin B3 serum Nicotinic Acid 99% niacinamide

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    Raw Material Vitamin B3 serum Nicotinic Acid 99% niacinamide Xi'an Quanao Biotech Co., Ltd. is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, he

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-29-86719484

    Address:B-1604,Juncheng Guoji, Taiyuan Road, Weiyang distirct

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    98-92-0

    MSDS/COA Download

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    FOB Price:  USD $ 40.0-40.0/Kilogram

    1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery by well-reputed shipping lines. 4.Trial order is available for testing after samples. 5.We will inform you all the information at every

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-29-81772657

    Address:Gaoxin 4th road, High-tech zone,

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  • Nicotinamide

  • Casno:

    98-92-0

    Nicotinamide

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

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    Enbridge PharmTech Co., Ltd. is an innovative company integrated with R&D, manufacturing, marketing and distribution of intermediates and fine chemicals, mainly used to pharmaceuti

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-510-83591909

    Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China

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  • Casno:

    98-92-0

    Nicotinamide

    Min.Order: 5 Metric Ton

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    Nicotinamide, 98% Nicotinamide CAS.: 98-92-0. Product Name: Nicotinamide Appearance: white Powder CAS.: 98-92-0 Detection Method: HPLC Purity: 98% Shelf life: 2Years MF: C6H6N2O MW: 122.12 GMP factory 100% High Quality Nicotinam

    Welcome to Henan Sinotech! Sinotech Corporation has exceptional sourcing ability for chemicals used in Organic Fine Chemicals and APIs; Inorganic chemicals; Flame Retardants;OLED

  •  Henan Sinotech Import&Export Corporation

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-371-86181678

    Address:No. 260, Dongming Road,Jinshui District

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    98-92-0

    MSDS/COA Download

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    Min.Order: 1 Kilogram

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    Nicotinamide / Niacinamide C.A.S NO. : 98-92-0 Synonyms: 3-Pyridinecarboxamide Molecular formula: C6H6N2O Molecular weight : 122.12 Assay: 99% Characteristic: White crystalline powder Melting point: 128-131℃ Boiling point: 150-1

    Shaanxi Mingqi Chemical Co., Ltd is committed to the development of import and export trade in the production, operation and plant extracts of pharmaceutical raw materials and inte

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:18092428356

    Address:Weiyang District

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    98-92-0

    MSDS/COA Download

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    Min.Order: 10 Gram

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    Hubei Jusheng Technology Co., Ltd., is a large group corporation which engaged in the R&D and manufacture of chemicals, Pharmaceuticals and intermediates. We have earned ourselves

  •  Hubei Jusheng Technology Co., Ltd.,

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-18871490254

    Address:High-tech Industrial Park,Tianmen city,Hubei province.

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  • Vitamin B3 Manufacturer 98-92-0 For Promote Hair Growth And Prevent Alopecia

  • Casno:

    98-92-0

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    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

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     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+8615102730682

    Address:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China

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  • NicotinaMide

  • Casno:

    98-92-0

    NicotinaMide

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    Product Name: Nicotinamide Synonyms: 3-PYRIDINECARBOXAMIDE;3-PYRIDINE CARBOXYLIC ACID AMIDE;3-PYRIDINECARBOXYLIC AMIDE;TIMTEC-BB SBB004283;NICETHAMIDUM;NIACINAMIDE;NICOTINIC ACID AMIDE;NICOTINAMIDE

    Our company engages in Electronic chemicals such as OLED,Photoresist chemical,Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

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  • New production CAS 98-92-0 with best quality

  • Casno:

    98-92-0

    New production CAS 98-92-0 with best quality

    Min.Order: 1 Kilogram

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    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is (Wen Xi Pharma), including three subs

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

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    98-92-0

    MSDS/COA Download

    BLOOM TECH Advanced API/Technology support NicotinaMide CAS 98-92-0

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Inquiry guide 1.Please send the quantity(Weight) to us, we will arrange our sales to provide the one-for-one service for you. 2.Then we will provide the professional quotation list for you, it will be including all the factors in who

    WHO WE ARE 1.We Focus on the technology of Organic Synthesis since 2008. 2.API/Pharmaceutical intermediate/Fine chemical/New material/Extraction etc. 3.Chemical reagent: Over 300,0

  •  Shaanxi BLOOM TECH Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-29-86470566

    Address:Block A of Central Mansion, No.113 of Weiyang Rd, ETDZ, Xi'an, Shaanxi 710016, China

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  • Nicotinamide/ LIDE PHARMA- Factory supply / Best price

  • Casno:

    98-92-0

    Nicotinamide/ LIDE PHARMA- Factory supply / Best price

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&

    LIDE PHARMACEUTICALS LIMITED is one of the fastest growing pharmaceutical company in China. We have developed strategic partnership with our manufacturing associates having state o

  •  LIDE PHARMACEUTICALS LIMITED

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

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  • Nicotinamide CAS NO.98-92-0 with low price high purity China supplier

  • Casno:

    98-92-0

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    Nicotinamide CAS NO.98-92-0 with low price high purity China supplier

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Chemistry

Molecular Structure of Nicotinamide (CAS NO.98-92-0):

IUPAC Name: pyridine-3-carboxamide
Empirical Formula: C6H6N2O
Molecular Weight: 122.1246
EINECS: 202-713-4
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 33.2Å2
Index of Refraction: 1.57
Molar Refractivity: 33.27 cm3
Molar Volume: 101.3 cm3
Surface Tension: 54.8 dyne/cm
Density: 1.204 g/cm3
Flash Point: 156 °C
Enthalpy of Vaporization: 57.74 kJ/mol
Boiling Point: 334.4 °C at 760 mmHg
Vapour Pressure: 0.000128 mmHg at 25°C
Storage temp: 0-6°C
Form: powder
Color: white
Water Solubility: 1000 g/L (20 ºC)
Merck: 14,6523
BRN: 383619
Stability: Stable. Incompatible with strong oxidizing agents
Melting point: 128-131 °C
Product Categories: Biochemistry; Vitamins; Nutritional Supplements; Vitamins and derivatives; Vitamin Ingredients; Miscellaneous Compounds

Uses

 Niacinamide (CAS NO.98-92-0) is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals and cosmetics, it is also an inhibitor of sirtuins and has been reported to restore cognition in Alzheimer's Disease transgenic mice, also  has been reported to be an effective skin whitener in topical application.

Production

 For production of niacinamide (CAS NO.98-92-0) in the past, methylethylpyridine was oxidized with nitric acid to yield niacin, and β-picoline was treated with air and ammonia to produce the nitrile that was then hydrolyzed to niacin-amide. A more modem process can produce both niacin and niacinamide (CAS NO.98-92-0) from a single feedstock, either β-picoline or 2-methyl-5-ethylpyridine by oxidative ammonolysis, a combination of oxidation and amination.
 Either niacin or niacinamide (CAS NO.98-92-0) can be selectively isolated from the hydrolysis by varying the hydrolysis time and nitrite concentration. A higher hydrolysis temperature favors production of niacin.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 2500mg/kg (2500mg/kg)   Pharmaceutical Chemistry Journal Vol. 20, Pg. 29, 1986.
mouse LD50 intraperitoneal 2050mg/kg (2050mg/kg)   Radiation Research. Vol. 109, Pg. 479, 1987.
mouse LD50 oral 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. 6, Pg. 545, 1982.
mouse LD50 subcutaneous 2gm/kg (2000mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 19, Pg. 48, 1946.
rat LD50 oral 3500mg/kg (3500mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1390, 1986.
rat LD50 subcutaneous 1680mg/kg (1680mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 19, 1946.

Safety Profile

Hazard Codes: Xi
Risk Statements: 36/37/38: Irritating to eyes, respiratory system and skin 
Safety Statements: 26-36-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection.
Nicotinamide rarely causes side effects, and is considered generally safe as a food additive, and as a component in cosmetics and medication.
 

Specification

 Nicotinamide , with CAS number of 98-92-0, can be called Niamide ; Niacinamide/Nicotinamide ; Austrovit PP ; beta.-Pyridinecarboxamide ; Nikotinsaeureamid ; Amid kyseliny nikotinove ; Nicotinamidum ; Pyridine-3-carboxylic acid amide ; Nikotinsaeureamid ; Nicotinamide(Vitamin B3) ; a-Alanine,N-[(2R)-2,4-dihydroxy-3,3- dimethyl-1-oxobutyl]- ; 3-Pyridinecarboxamide ; Nicotinamida ; Niacinamide ; 3-Pyridinecarboxylic acid amide ; Nicotine acid amide . Nicotinamide, also known as niacinamide and Nicotinic acid amide, is the amide of Nicotinic acid (vitamin B3). It is a water-soluble vitamin and is part of the vitamin B group.Nicotinic acid(also known as niacin)can be converte to niacinamide in vivo. It is a white to off white powder.

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