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| CAS No.: | 99-03-6 |
|---|---|
| Name: | 3-Aminoacetophenone |
| Article Data: | 158 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H9NO |
| Molecular Weight: | 135.166 |
| Synonyms: | Acetophenone,3'-amino- (8CI);1-(3-Aminophenyl)ethanone;1-Acetyl-3-aminobenzene;3-Acetylaniline;3-Acetylphenylamine;3-Methylcarbonylaniline;NSC 7637;m-Acetylaniline;m-Aminoacetophenone;b-Aminoacetophenone;3-Aminoacetophenone; |
| EINECS: | 202-722-3 |
| Density: | 1.096 g/cm3 |
| Melting Point: | 94-98 °C(lit.) |
| Boiling Point: | 290.3 °C at 760 mmHg |
| Flash Point: | 129.4 °C |
| Solubility: | 7.056g/L(37.5 oC) |
| Appearance: | yellow to light brown crystalline powder |
| Hazard Symbols: |
 Xn, Xi
|
| Risk Codes: | 22-36/37/38 |
| Safety: | 36/37-36-26 |
| PSA: | 43.09000 |
| LogP: | 2.05260 |
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- 99533-99-03'-MERCAPTOACETAMINOPHEN
| Conditions | Yield |
|---|---|
| With cadmium sulphide; ammonium formate In water at 20℃; for 14h; Inert atmosphere; Irradiation; Sealed tube; chemoselective reaction; | 100% |
| With water; oxalic acid; titanium(IV) oxide for 3h; Wavelength; Irradiation; Inert atmosphere; Sealed tube; Green chemistry; chemoselective reaction; | 100% |
| With hydrogen In methanol at 70℃; under 3750.38 - 7500.75 Torr; for 4h; Temperature; Reagent/catalyst; Solvent; | 99% |
- 54060-30-9
3-acetylenephenylamine
- 99-03-6
1-(3-aminophenyl)ethanone
| Conditions | Yield |
|---|---|
| With silver hexafluoroantimonate In methanol; water at 120℃; for 24h; Sealed tube; | 97% |
| With C22H20AuN3O2P(1+)*CF3O3S(1-); water; silver trifluoromethanesulfonate; acetic acid at 100℃; for 10h; | 91% |
| With water at 200℃; for 0.333333h; microwave irradiation; | 90% |
- 94066-64-5
bis-(3-acetyl-phenyl)-diazene
- 99-03-6
1-(3-aminophenyl)ethanone
| Conditions | Yield |
|---|---|
| With zinc; hydrazinium monoformate In methanol for 0.1h; Heating; | 93% |
| With ammonium formate; magnesium In methanol at 20℃; for 0.15h; | 91% |
| With ammonium chloride; zinc In methanol at 20℃; for 0.2h; | 91% |
| Conditions | Yield |
|---|---|
| With ethanol; titanium(IV) oxide for 0.25h; Irradiation; | A 92% B n/a C n/a |
- 998-39-0
tributylgermanium hydride
- 70334-60-0
3-(azidophenyl) methyl ketone
C
- 99-03-6
1-(3-aminophenyl)ethanone
| Conditions | Yield |
|---|---|
| With thiophenol In toluene for 0.5h; Heating; | A 1% B 2% C 92% |
| Conditions | Yield |
|---|---|
| With copper(I) oxide; ammonium hydroxide In 1-methyl-pyrrolidin-2-one at 80℃; for 15h; | 92% |
| With copper(I) oxide; ammonium hydroxide; N1-(furan-2-ylmethyl)-N2-(2-methylnaphthalen-1-yl)oxalamide; potassium hydroxide In ethanol at 80℃; for 24h; Schlenk technique; Inert atmosphere; | 64% |
| Stage #1: 1-(3-Bromophenyl)ethanone With copper(l) iodide; D-glucosamine hydrochloride; potassium carbonate In water; acetone at 90℃; for 0.166667h; Stage #2: With ammonia In water; acetone at 90℃; for 30h; | 62% |
- 99-03-6
1-(3-aminophenyl)ethanone
| Conditions | Yield |
|---|---|
| With indium; ammonium chloride In ethanol for 2.5h; Heating; | 91% |
- 151224-49-6
(E)-1,1'-(diazene-1,2-diyl)bis(1,3-phenylene)bis(ethan-1-one)
- 99-03-6
1-(3-aminophenyl)ethanone
| Conditions | Yield |
|---|---|
| With nickel; hydrazinium monoformate In methanol for 0.15h; Heating; | 90% |
- 70334-60-0
3-(azidophenyl) methyl ketone
- 99-03-6
1-(3-aminophenyl)ethanone
| Conditions | Yield |
|---|---|
| With samarium diiodide In tetrahydrofuran for 1.25h; Ambient temperature; | 89% |
| With tellurium; water at 275℃; for 4h; | 89% |
| With ammonium formate; copper In water for 8h; Reflux; chemoselective reaction; | 84% |
- 99-03-6
1-(3-aminophenyl)ethanone
| Conditions | Yield |
|---|---|
| With N-Bromosuccinimide; CYANAMID; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 20℃; for 1h; Reagent/catalyst; chemoselective reaction; | 87% |
| With N-Bromosuccinimide; N-methoxylamine hydrochloride; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 20℃; | 78% |
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Chemistry
IUPAC Name: 3-Aminoacetophenone
The MF of 3-Aminoacetophenone (99-03-6) is C8H9NO.
The MW of 3-Aminoacetophenone (99-03-6) is 135.16.
Synonyms of 3-Aminoacetophenone (99-03-6): 3-Aminoacetophenone ; 1-(3-Aminophenyl)ethanone ; Ethanone, 1-(3-aminophenyl)- ; 1-(3-Aminophenyl)Ethan-1-One ; 3′-Aminoacetophenone ; 3-Acetylaniline ; 3-Amino acetophenone
Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Acetophenones & Derivatives (substituted);API intermediates
Form: yellow to light brown crystalline powder
Index of Refraction: 1.571
EINECS: 202-722-3
Density: 1.096 g/ml
Flash Point: 129.4 °C
Boiling Point: 290.3 °C
Melting Point: 94-98 °C
Merck: 14,413
BRN: 386009
Uses
3-Aminoacetophenone (99-03-6) is used as phenylephrine synthetic drugs, hypnotics zaleplon, etc. Also as a raw material in organic synthesis.
Production
It derived from the Inter-nitroacetophenone by using iron powder reduction.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LDLo | intraperitoneal | 2048mg/kg (2048mg/kg) | "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 2, Pg. 55, 1950. | |
| rabbit | LD50 | skin | 4340uL/kg (4.34mL/kg) | AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954. | |
| rat | LD50 | oral | 1870mg/kg (1870mg/kg) | AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954. |
Safety Profile
Safety information of 3-Aminoacetophenone (99-03-6):
Hazard Codes 
Xn,Xi
Risk Statements
22 Harmful if swallowed
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
36/37 Wear suitable protective clothing and gloves
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany 2
RTECS AM5800000
Hazard Note Irritant
TSCA T
HS Code 29223900