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| CAS No.: | 991-42-4 |
|---|---|
| Name: | NORBORMIDE |
| Molecular Structure: | |
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| Formula: | C33H25 N3 O3 |
| Molecular Weight: | 511.58 |
| Synonyms: | 5-Norbornene-2,3-dicarboximide,5-(a-hydroxy-a-2-pyridylbenzyl)-7-(a-2-pyridylbenzylidene)-(7CI,8CI); 5-(a-Hydroxy-a-2-pyridylbenzyl)-7-(a-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide;5-[(a-hydroxy-a-2-pyridyl)benzyl]-7-[a-(2-pyridyl)benzyl]-5-norbornene-2,3-dicarboximide;Compound S 6999; McN 1025; NSC 101316; Norbormide; Raticate; S 6999; Shoxin |
| Density: | 1.346g/cm3 |
| Melting Point: | 190-198° |
| Boiling Point: | 780.539°C at 760 mmHg |
| Flash Point: | 425.855°C |
| Solubility: | 60mg/L(room temperature) |
| Appearance: | white to light yellow crystal powder |
| Hazard Symbols: | Toxic by ingestion. |
| Risk Codes: | 22 |
| Safety: | Poison by ingestion and intravenous routes. A rodenticide. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 92.18000 |
| LogP: | 4.61820 |
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Chemistry
Empirical Formula: C33H25N3O3
Molecular Weight: 511.5699 g/mol
EINECS: 213-589-6
Flash Point: 425.9 °C
Enthalpy of Vaporization: 119.14 kJ/mol
Boiling Point: 780.5 °C at 760 mmHg
Vapour Pressure: 1.19E-25 mmHg at 25 °C
Appearance: Colorless to off-white crystalline powder
Structure of Norbormide (CAS NO.991-42-4):
Uses
Norbormide (CAS NO.991-42-4) has been used as a selective rat poison.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | oral | 1gm/kg (1000mg/kg) | Yakkyoku. Pharmacy. Vol. 31, Pg. 1385, 1980. | |
| dog | LD50 | oral | 1gm/kg (1000mg/kg) | Yakkyoku. Pharmacy. Vol. 31, Pg. 1385, 1980. | |
| domestic animals - goat/sheep | LD | oral | > 100mg/kg (100mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 288, 1965. | |
| guinea pig | LD50 | oral | 300mg/kg (300mg/kg) | Yakkyoku. Pharmacy. Vol. 31, Pg. 1385, 1980. | |
| hamster | LD50 | oral | 140mg/kg (140mg/kg) | Pesticide Manual. Vol. 8, Pg. 607, 1987. | |
| monkey | LD50 | oral | 1gm/kg (1000mg/kg) | Yakkyoku. Pharmacy. Vol. 31, Pg. 1385, 1980. | |
| mouse | LD50 | intraperitoneal | > 1gm/kg (1000mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62(2), Pg. 945, 1966. | |
| mouse | LD50 | oral | 10mg/kg (10mg/kg) | Yakkyoku. Pharmacy. Vol. 38, Pg. 1331, 1987. | |
| pig | LDLo | oral | > 1gm/kg (1000mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977. | |
| rabbit | LD50 | intraperitoneal | > 1gm/kg (1000mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62(2), Pg. 945, 1966. | |
| rabbit | LD50 | oral | 1gm/kg (1000mg/kg) | Yakkyoku. Pharmacy. Vol. 31, Pg. 1385, 1980. | |
| rat | LD50 | intraperitoneal | 20mg/kg (20mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62(2), Pg. 94S, 1966. | |
| rat | LD50 | oral | 3800ug/kg (3.8mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: ANTIPSYCHOTIC | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 66, Pg. 224, 1970. |
| rat | LDLo | intravenous | 250ug/kg (0.25mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | European Journal of Pharmacology. Vol. 16, Pg. 117, 1971. |
| rat | LDLo | unreported | 3714ug/kg (3.714mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 7, Pg. 1506, 1965. |
Safety Profile
Poison by ingestion and intravenous routes. A rodenticide. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: 
Xn
Risk Statements: 22
R22:Harmful if swallowed.
Specification
Norbormide ,its cas register number is 991-42-4. It also can be called Shoxin ; 3a,4,7,7a-Tetrahydro-5-(hydroxyphenyl-2-pyridinylmethyl)-8-(phenyl-2-pyridinylmethylene)-4,7-methano-1H-isoindole-1,3(2H)-dione ;and Raticate . Its mechanisms of action is acting as a vasoconstrictor and calcium channel blocker due to a species specific action of opening the permeability transition pores in rat mitochondria, but it is selectively toxic to rats and has relatively low toxicity to other species. When heated to decomposition, Norbormide (CAS NO.991-42-4) emits toxic fumes of nitrogen oxides.