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99497-03-7

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Basic Information
CAS No.: 99497-03-7
Name: Domperidone maleate
Molecular Structure:
Molecular Structure of 99497-03-7 (Domperidone maleate)
Formula: C22H24ClN5O2.C4H4O4
Molecular Weight: 541.98
Synonyms: 5-chloro-1-[1-[3-(2-oxo-3H-benzoimidazol-1-yl)propyl]-4-piperidyl]-3H-benzoimidazol-2-one;R 33,812;but-2-enedioic acid; 5-chloro-1-[1-[3-(2-oxo-3H-benzoimidazol-1-yl)propyl]-4-piperidyl]-3H-benzoimidazol-2-one;KW-5338;
EINECS: 801-827-7
Melting Point: 236 - 239 °C
Boiling Point: 778.5 °C at 760 mmHg
Flash Point: 424.7 °C
PSA: 153.42000
LogP: 3.00290
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  • Domperidone maleate

  • Casno:

    99497-03-7

    Domperidone maleate

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  • Domperidone maleate 99497-03-7

  • Casno:

    99497-03-7

    Domperidone maleate 99497-03-7

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Chemistry


IUPAC Name:5-Chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one maleate
Molecular Formula:C22H24ClN5O2.C4H4O4
Molecular Weight:541.99 g/mol
Melting Point:236 - 239 °C
Appearance: white powder

Uses

Domperidone maleate (CAS NO.99497-03-7) is a dopamine antagonist used as an antiemetic for the short term treatment of nausea and vomiting of various etiologies.

Toxicity Data With Reference

Toxicity: ORL-RAT LD50 5243 mg kg-1, IPR-RAT LD50 61 mg kg-1, ORL-MUS LD50 > 8000 mg kg-1 .

Analytical Methods

Domperidone maleate(99497-03-7) was determined by several methods including colorimetric methods, spectrophotometric methods, high-performance thin-layer chromatography, high-performance liquid chromatography and titrimetric methods.